ES8301206A1 - "procedimiento para la preparacion de insulina humana o de sus derivados". - Google Patents

"procedimiento para la preparacion de insulina humana o de sus derivados".

Info

Publication number
ES8301206A1
ES8301206A1 ES508657A ES508657A ES8301206A1 ES 8301206 A1 ES8301206 A1 ES 8301206A1 ES 508657 A ES508657 A ES 508657A ES 508657 A ES508657 A ES 508657A ES 8301206 A1 ES8301206 A1 ES 8301206A1
Authority
ES
Spain
Prior art keywords
derivatives
insulin
pig
preparation
human insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508657A
Other languages
English (en)
Other versions
ES508657A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8301206A1 publication Critical patent/ES8301206A1/es
Publication of ES508657A0 publication Critical patent/ES508657A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE INSULINA HUMANA O DE SUS DERIVADOS A PARTIR DE INSULINA DE PORCINO O DE SUS DERIVADOS. CONSISTE EN LA REACCION DE INSULINA DE PORCINO O UN DERIVADO SUYO A UN VALOR DE PH INFERIOR A SU PUNTO ISOELECTRICO, COMPRENDIDO ENTRE 4 Y 6, CON UN EXCESO DE UN ESTER DE TREOMINA O DE UNO DE SUS DERIVADOS, EN PRESENCIA DE TRIPSINA O DE UN FERMENTO SIMILAR; SEGUIDA DE LA SEPARACION EVENTUAL DEL GRUPO ESTER. >ESTE COMPUESTO TIENE APLICACIONES PARA EL TRATAMIENTO DE LA DIABETES MELITUS.
ES508657A 1981-01-17 1982-01-12 "procedimiento para la preparacion de insulina humana o de sus derivados". Granted ES508657A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813101382 DE3101382A1 (de) 1981-01-17 1981-01-17 "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"

Publications (2)

Publication Number Publication Date
ES8301206A1 true ES8301206A1 (es) 1982-11-16
ES508657A0 ES508657A0 (es) 1982-11-16

Family

ID=6122819

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508657A Granted ES508657A0 (es) 1981-01-17 1982-01-12 "procedimiento para la preparacion de insulina humana o de sus derivados".

Country Status (14)

Country Link
US (1) US4601852A (es)
EP (1) EP0056951B1 (es)
JP (1) JPS57138396A (es)
KR (1) KR880001107B1 (es)
AT (1) ATE13893T1 (es)
AU (1) AU559235B2 (es)
CA (1) CA1190496A (es)
DE (2) DE3101382A1 (es)
DK (1) DK149615B (es)
ES (1) ES508657A0 (es)
FI (1) FI79860C (es)
GR (1) GR74758B (es)
IL (1) IL64789A (es)
ZA (1) ZA82261B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
JPS58501455A (ja) * 1981-09-15 1983-09-01 ノルデイスク　インシユリンラボラトリユ−ム 人インシユリンまたはそのｂ−３０エステルの製造法
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
DE3381980D1 (de) * 1982-04-23 1990-12-13 Wako Pure Chem Ind Ltd Verfahren zur halbsynthese von menschlichem insulin und dazu zu verwendende alkalische protease.
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
US5106510A (en) * 1991-03-08 1992-04-21 Enviroguard, Inc. Combined filtration and fixation of heavy metals
DK0547544T3 (da) * 1991-12-18 1997-09-08 Hoechst Ag Fremgangsmåde til fremstilling af insulinholdige opløsninger.
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
JP2001521006A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 不溶性インシュリン組成物
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US6964561B2 (en) * 2002-04-23 2005-11-15 V System Composites, Inc. High-performance infusion system for VARTM fabrication
US20070108646A1 (en) * 2005-11-15 2007-05-17 Louderback Michael J Method of fabricating a composite structure with details

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
DE2460753A1 (de) * 1974-12-21 1976-06-24 Hoechst Ag Verfahren zur herstellung von humaninsulin
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Also Published As

Publication number Publication date
AU559235B2 (en) 1987-03-05
FI79860B (fi) 1989-11-30
KR830008995A (ko) 1983-12-16
GR74758B (es) 1984-07-11
US4601852A (en) 1986-07-22
CA1190496A (en) 1985-07-16
DE3264149D1 (en) 1985-07-25
JPS57138396A (en) 1982-08-26
AU7955482A (en) 1982-07-29
ATE13893T1 (de) 1985-07-15
EP0056951B1 (de) 1985-06-19
FI820117L (fi) 1982-07-18
DE3101382A1 (de) 1982-09-02
IL64789A0 (en) 1982-03-31
KR880001107B1 (ko) 1988-06-29
ZA82261B (en) 1982-12-29
FI79860C (fi) 1990-03-12
DK149615B (da) 1986-08-11
EP0056951A1 (de) 1982-08-04
ES508657A0 (es) 1982-11-16
IL64789A (en) 1985-09-29
JPH0141317B2 (es) 1989-09-05
DK16682A (da) 1982-07-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020715