ES8706693A1 - Procedimiento para la produccion de derivados del acido 7-amino-3-alcoximetil-3-cefem-4-carboxilico - Google Patents
Procedimiento para la produccion de derivados del acido 7-amino-3-alcoximetil-3-cefem-4-carboxilicoInfo
- Publication number
- ES8706693A1 ES8706693A1 ES555612A ES555612A ES8706693A1 ES 8706693 A1 ES8706693 A1 ES 8706693A1 ES 555612 A ES555612 A ES 555612A ES 555612 A ES555612 A ES 555612A ES 8706693 A1 ES8706693 A1 ES 8706693A1
- Authority
- ES
- Spain
- Prior art keywords
- production
- aca derivatives
- derivatives
- aca
- alkoxymethylcephem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
Abstract
METODO DE PRODUCIR DERIVADOS DEL ACIDO 7-AMINO-3-ALCOXIMETIL-3-CEFEM-4-CARBOXILICO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R-OH, EN PRESENCIA DE TRIFLUORURO DE BORO O DE UN COMPLEJO DE ESTE, PARA OBTENER DERIVADOS DEL ACIDO 7-AMINO-3-ALCOXIMETIL-3-CEFEM-4-CARBOXILICO DE FORMULA (I), EN LA QUE R ES UN GRUPO ALQUILO INFERIOR. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO, TAL COMO NITRILO ORGANICO COMO ACETONITRILO O PROPIONITRILO, UN NITROALCANO TAL COMO NITROMETANO, O UNA SULFONA, TAL COMO SULFOLAN, Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 70GC. TIENEN APLICACIONES FARMACEUTICAS POR SUS EFECTOS ANTIBIOTICOS. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0166985A AT384222B (de) | 1985-06-03 | 1985-06-03 | Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren |
Publications (2)
Publication Number | Publication Date |
---|---|
ES555612A0 ES555612A0 (es) | 1987-07-01 |
ES8706693A1 true ES8706693A1 (es) | 1987-07-01 |
Family
ID=3518423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555612A Expired ES8706693A1 (es) | 1985-06-03 | 1986-06-02 | Procedimiento para la produccion de derivados del acido 7-amino-3-alcoximetil-3-cefem-4-carboxilico |
Country Status (15)
Country | Link |
---|---|
US (1) | US5580978A (es) |
EP (1) | EP0204657B1 (es) |
JP (1) | JPH0649704B2 (es) |
AT (2) | AT384222B (es) |
AU (1) | AU602124B2 (es) |
DE (1) | DE3688302T2 (es) |
DK (1) | DK164060C (es) |
ES (1) | ES8706693A1 (es) |
FI (1) | FI86183C (es) |
HK (1) | HK49796A (es) |
IE (1) | IE59911B1 (es) |
IL (1) | IL78983A (es) |
NZ (1) | NZ216366A (es) |
PH (1) | PH22895A (es) |
ZA (1) | ZA864134B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2061485T3 (es) * | 1986-10-02 | 1994-12-16 | Asahi Chemical Ind | Procedimiento para la fabricacion de 3-alcoximetilcefalosporinas. |
JP2612493B2 (ja) * | 1988-05-24 | 1997-05-21 | 旭化成工業株式会社 | 3―置換メチル―3―セフェム―4―カルボン酸類の製造方法 |
DE4004370A1 (de) * | 1990-02-13 | 1991-08-14 | Hoechst Ag | Verfahren zur herstellung von 7-amino-3-methoxymethyl-ceph-3-em-4-carbonsaeure |
ES2075365T3 (es) | 1990-11-07 | 1995-10-01 | Sankyo Co | Procedimiento para la preparacion de derivados de 3-alcoximetil cefalosporina. |
AT401177B (de) * | 1993-10-22 | 1996-07-25 | Biochemie Gmbh | Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten |
US20030135041A1 (en) * | 2002-01-04 | 2003-07-17 | Orchid Chemicals & Pharmaceuticals Limited, India | Synthesis of ceftiofur intermediate |
WO2013041999A1 (en) | 2011-09-20 | 2013-03-28 | Dhanuka Laboratories Ltd. | An improved process for cefpodoxime acid |
WO2017153824A1 (en) | 2016-03-07 | 2017-09-14 | Dhanuka Laboratories Ltd. | A process for alkylating the hydroxymethyl group at position -3 of cephalosporins |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1241656A (en) * | 1967-08-21 | 1971-08-04 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin compounds |
GB1565941A (en) * | 1977-02-08 | 1980-04-23 | Toyama Chemical Co Ltd | Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids |
HU182411B (en) * | 1981-11-03 | 1984-01-30 | Richter Gedeon Vegyeszet | Process for preparing eburnamonine derivatives |
JPS57192392A (en) * | 1981-05-19 | 1982-11-26 | Sankyo Co Ltd | Production of 3-alkoxymethylcephalosporin |
JPS5896091A (ja) * | 1981-12-01 | 1983-06-07 | Sankyo Co Ltd | 3−アルコキシメチルセフアロスポリン類の製造法 |
JPS59163387A (ja) * | 1983-03-07 | 1984-09-14 | Sankyo Co Ltd | 3−アルコキシメチルセフアロスポリンの製造方法 |
ES2061485T3 (es) * | 1986-10-02 | 1994-12-16 | Asahi Chemical Ind | Procedimiento para la fabricacion de 3-alcoximetilcefalosporinas. |
-
1985
- 1985-06-03 AT AT0166985A patent/AT384222B/de not_active IP Right Cessation
-
1986
- 1986-05-23 DE DE86810224T patent/DE3688302T2/de not_active Expired - Fee Related
- 1986-05-23 AT AT86810224T patent/ATE88476T1/de not_active IP Right Cessation
- 1986-05-23 EP EP86810224A patent/EP0204657B1/en not_active Expired - Lifetime
- 1986-05-30 NZ NZ216366A patent/NZ216366A/xx unknown
- 1986-05-30 IE IE144086A patent/IE59911B1/en not_active IP Right Cessation
- 1986-06-02 ES ES555612A patent/ES8706693A1/es not_active Expired
- 1986-06-02 PH PH33843A patent/PH22895A/en unknown
- 1986-06-02 IL IL78983A patent/IL78983A/xx not_active IP Right Cessation
- 1986-06-02 DK DK259486A patent/DK164060C/da not_active IP Right Cessation
- 1986-06-02 FI FI862336A patent/FI86183C/fi not_active IP Right Cessation
- 1986-06-02 JP JP61129034A patent/JPH0649704B2/ja not_active Expired - Lifetime
- 1986-06-02 AU AU58245/86A patent/AU602124B2/en not_active Ceased
- 1986-06-03 ZA ZA864134A patent/ZA864134B/xx unknown
-
1995
- 1995-04-13 US US08/421,099 patent/US5580978A/en not_active Expired - Lifetime
-
1996
- 1996-03-21 HK HK49796A patent/HK49796A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3688302T2 (de) | 1993-10-21 |
IE59911B1 (en) | 1994-04-20 |
FI86183C (fi) | 1992-07-27 |
NZ216366A (en) | 1989-08-29 |
ES555612A0 (es) | 1987-07-01 |
EP0204657A2 (en) | 1986-12-10 |
AU5824586A (en) | 1986-12-11 |
IE861440L (en) | 1986-12-03 |
FI862336A (fi) | 1986-12-04 |
IL78983A (en) | 1991-01-31 |
US5580978A (en) | 1996-12-03 |
AT384222B (de) | 1987-10-12 |
DK164060B (da) | 1992-05-04 |
DK164060C (da) | 1992-09-28 |
DK259486D0 (da) | 1986-06-02 |
EP0204657B1 (en) | 1993-04-21 |
FI86183B (fi) | 1992-04-15 |
EP0204657A3 (en) | 1988-08-17 |
ATE88476T1 (de) | 1993-05-15 |
ZA864134B (en) | 1988-01-27 |
HK49796A (en) | 1996-03-29 |
AU602124B2 (en) | 1990-10-04 |
DE3688302D1 (de) | 1993-05-27 |
DK259486A (da) | 1986-12-04 |
JPH0649704B2 (ja) | 1994-06-29 |
IL78983A0 (en) | 1986-09-30 |
ATA166985A (de) | 1987-03-15 |
PH22895A (en) | 1989-01-19 |
FI862336A0 (fi) | 1986-06-02 |
JPS61289093A (ja) | 1986-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20070507 |