ES2075365T3 - Procedimiento para la preparacion de derivados de 3-alcoximetil cefalosporina. - Google Patents

Procedimiento para la preparacion de derivados de 3-alcoximetil cefalosporina.

Info

Publication number
ES2075365T3
ES2075365T3 ES91310289T ES91310289T ES2075365T3 ES 2075365 T3 ES2075365 T3 ES 2075365T3 ES 91310289 T ES91310289 T ES 91310289T ES 91310289 T ES91310289 T ES 91310289T ES 2075365 T3 ES2075365 T3 ES 2075365T3
Authority
ES
Spain
Prior art keywords
sub
compound
formula
cefalosporina
alcoximetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91310289T
Other languages
English (en)
Inventor
Yukio Hirayama
Syuji Sayama
Kiyomi Yamaguchi
Shigeru Miyamoto
Yasuo Takahashi
Keisuke Kato
Tomio Sasao
Kiyoshi Iijima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2075365T3 publication Critical patent/ES2075365T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN COMPUESTO DE LA FORMULA (I): O UNA SAL DEL MISMO, SE PREPARA AL REACCIONAR UN ACIDO 7-AMINOCEFALOSPORANICO O UNA SAL DEL MISMO, CON UNA SOLUCION QUE COMPRENDE UN COMPUESTO DE LA FORMULA ROSO SUB 3H EN UN COMPUESTO DE LA FORMULA ROH, Y EN PRESENCIA DE AL MENOS UN COMPUESTO DE LA FORMULA B(OR) SUB 3 O DE UN COMPUESTO DE LA FORMULA CH SUB 2(OR) SUB 2; EN EL CUAL, EN CADA UNO DE DICHOS COMPUESTOS DE LAS FORMULAS (I), ROSO SUB 3H, ROH, B(OR) SUB 3 Y CH SUB 2(OR)2, R REPRESENTA UN GRUPO ALCALINO PROVISTO, DE 1 A 6 ATOMOS DE CARBONO.
ES91310289T 1990-11-07 1991-11-06 Procedimiento para la preparacion de derivados de 3-alcoximetil cefalosporina. Expired - Lifetime ES2075365T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30207190 1990-11-07

Publications (1)

Publication Number Publication Date
ES2075365T3 true ES2075365T3 (es) 1995-10-01

Family

ID=17904568

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91310289T Expired - Lifetime ES2075365T3 (es) 1990-11-07 1991-11-06 Procedimiento para la preparacion de derivados de 3-alcoximetil cefalosporina.

Country Status (10)

Country Link
US (1) US5451675A (es)
EP (1) EP0485204B1 (es)
JP (1) JP3206821B2 (es)
KR (1) KR0140196B1 (es)
AT (1) ATE123286T1 (es)
DE (1) DE69110107T2 (es)
DK (1) DK0485204T3 (es)
ES (1) ES2075365T3 (es)
HK (1) HK1005452A1 (es)
IE (1) IE68511B1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
KR100343434B1 (ko) * 1999-10-13 2002-07-11 민경윤 7-아미노-3-메톡시메틸-3-세펨-4-카복실산의 제조방법
IN192344B (es) * 2001-01-30 2004-04-10 Ranbaxy Lab Ltd
WO2013041999A1 (en) 2011-09-20 2013-03-28 Dhanuka Laboratories Ltd. An improved process for cefpodoxime acid
EP3426663B1 (en) 2016-03-07 2020-01-29 Dhanuka Laboratories Ltd. A process for alkylating the hydroxymethyl group at position -3 of cephalosporins
CN105669701A (zh) * 2016-03-22 2016-06-15 陕西思尔生物科技有限公司 一种头孢泊肟酯中间体的合成方法
CN106478666B (zh) * 2016-09-22 2018-07-31 湖北凌晟药业有限公司 7-氨基-3-甲氧甲基-3-头孢烯-4-羧酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5896091A (ja) * 1981-12-01 1983-06-07 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリン類の製造法
JPS59163387A (ja) * 1983-03-07 1984-09-14 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリンの製造方法
AT384222B (de) * 1985-06-03 1987-10-12 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren
EP0262744B1 (en) * 1986-10-02 1994-03-23 Asahi Kasei Kogyo Kabushiki Kaisha A process for preparing 3-alkoxymethylcephalosphorins
JPS63115887A (ja) * 1986-11-04 1988-05-20 Asahi Chem Ind Co Ltd ７−アミノ−３−アルコキシメチルセフアロスポリン類の製造方法
JP2612493B2 (ja) * 1988-05-24 1997-05-21 旭化成工業株式会社 ３―置換メチル―３―セフェム―４―カルボン酸類の製造方法
DE4004370A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verfahren zur herstellung von 7-amino-3-methoxymethyl-ceph-3-em-4-carbonsaeure

Also Published As

Publication number Publication date
JPH04364188A (ja) 1992-12-16
DE69110107D1 (de) 1995-07-06
EP0485204A3 (en) 1992-09-23
IE913872A1 (en) 1992-05-20
HK1005452A1 (en) 1999-01-08
KR920009833A (ko) 1992-06-25
EP0485204A2 (en) 1992-05-13
DK0485204T3 (da) 1995-10-16
ATE123286T1 (de) 1995-06-15
US5451675A (en) 1995-09-19
EP0485204B1 (en) 1995-05-31
JP3206821B2 (ja) 2001-09-10
DE69110107T2 (de) 1996-02-01
KR0140196B1 (ko) 1998-06-01
IE68511B1 (en) 1996-06-26

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