ES2061485T3 - Procedimiento para la fabricacion de 3-alcoximetilcefalosporinas. - Google Patents

Procedimiento para la fabricacion de 3-alcoximetilcefalosporinas.

Info

Publication number
ES2061485T3
ES2061485T3 ES87201871T ES87201871T ES2061485T3 ES 2061485 T3 ES2061485 T3 ES 2061485T3 ES 87201871 T ES87201871 T ES 87201871T ES 87201871 T ES87201871 T ES 87201871T ES 2061485 T3 ES2061485 T3 ES 2061485T3
Authority
ES
Spain
Prior art keywords
alcoximetilcefalosporinas
procedure
manufacture
prepare
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87201871T
Other languages
English (en)
Inventor
Joji Nishikido
Kentaro Fukuzaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2061485T3 publication Critical patent/ES2061485T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 3-ALCOXIMETILCEFALOSPORINAS QUE SON UTILES COMO COMPUESTOS INTERMEDIOS PARA OBTENER VARIOS DERIVADOS DE CEFALOSPORINA, QUE TIENEN ACTIVIDAD ANTIMICROBIANA. DE ACUERDO CON EL PROCEDIMIENTO SE PUEDEN OBTENER FACILMENTE 3-ALCOXIMETILCEFALOSPORINAS CON ALTO RENDIMIENTO, A ESCALA COMERCIAL.
ES87201871T 1986-10-02 1987-09-30 Procedimiento para la fabricacion de 3-alcoximetilcefalosporinas. Expired - Lifetime ES2061485T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP23333186 1986-10-02
JP28777386 1986-12-04
JP18535687 1987-07-27
JP20829787 1987-08-24

Publications (1)

Publication Number Publication Date
ES2061485T3 true ES2061485T3 (es) 1994-12-16

Family

ID=27475214

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87201871T Expired - Lifetime ES2061485T3 (es) 1986-10-02 1987-09-30 Procedimiento para la fabricacion de 3-alcoximetilcefalosporinas.

Country Status (4)

Country Link
US (1) US4902793A (es)
EP (1) EP0262744B1 (es)
DE (1) DE3789412T2 (es)
ES (1) ES2061485T3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT384222B (de) * 1985-06-03 1987-10-12 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren
DE3783048T2 (de) * 1986-02-28 1993-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von cephalosporinverbindungen.
JP2612493B2 (ja) * 1988-05-24 1997-05-21 旭化成工業株式会社 ３―置換メチル―３―セフェム―４―カルボン酸類の製造方法
DE4004370A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verfahren zur herstellung von 7-amino-3-methoxymethyl-ceph-3-em-4-carbonsaeure
ATE123286T1 (de) 1990-11-07 1995-06-15 Sankyo Co Verfahren zur herstellung von 3-alkoxymethyl cephalosporinderivate.
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
PL2656879T3 (pl) 2006-12-10 2017-09-29 Chongxi Yu Przezskórne układy podania antybiotyków beta-laktamowych
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
EP2758407A1 (en) 2011-09-20 2014-07-30 Dhanuka Laboratories Ltd. An improved process for cefpodoxime acid
EP3426663B1 (en) 2016-03-07 2020-01-29 Dhanuka Laboratories Ltd. A process for alkylating the hydroxymethyl group at position -3 of cephalosporins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948906A (en) * 1967-08-21 1976-04-06 Glaxo Laboratories Limited Cephalosporin compounds
GB1241657A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
US3846416A (en) * 1967-08-21 1974-11-05 Glaxo Lab Ltd Cephalosporin compounds
GB1241656A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
JPS5896091A (ja) * 1981-12-01 1983-06-07 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリン類の製造法
JPS59163387A (ja) * 1983-03-07 1984-09-14 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリンの製造方法
AT384222B (de) * 1985-06-03 1987-10-12 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3alkoxymethyl-3-cephem-4-carbonsaeuren

Also Published As

Publication number Publication date
US4902793A (en) 1990-02-20
EP0262744A2 (en) 1988-04-06
DE3789412T2 (de) 1994-06-30
EP0262744A3 (en) 1989-10-04
DE3789412D1 (de) 1994-04-28
EP0262744B1 (en) 1994-03-23

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