KR830008995A - 인체 인슐린 및 그의 유도체의 제조방법 - Google Patents

인체 인슐린 및 그의 유도체의 제조방법 Download PDF

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Publication number
KR830008995A
KR830008995A KR1019820000188A KR820000188A KR830008995A KR 830008995 A KR830008995 A KR 830008995A KR 1019820000188 A KR1019820000188 A KR 1019820000188A KR 820000188 A KR820000188 A KR 820000188A KR 830008995 A KR830008995 A KR 830008995A
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South Korea
Prior art keywords
insulin
human insulin
derivative
trypsin
pig
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KR1019820000188A
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English (en)
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KR880001107B1 (ko
Inventor
오버마이어 라이너
루드비히 쥐르겐
자입케 게르하르트
Original Assignee
하인리히 베커, 베른하르트 베크
훽스트 아크티엔 게젤샤프트
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Application filed by 하인리히 베커, 베른하르트 베크, 훽스트 아크티엔 게젤샤프트 filed Critical 하인리히 베커, 베른하르트 베크
Publication of KR830008995A publication Critical patent/KR830008995A/ko
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Publication of KR880001107B1 publication Critical patent/KR880001107B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

인체 인슐린 및 그의 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 돼지 인슐린 또는 그의 유도체를 그의 등전점 이하의 pH에서 트레오닌 에스테르 또는 그의 유도체 과량과 트립신 또는 트립신양 효소존재하에 반응시킨 후 에스테르그룹을 임의로 제거시킴을 특징으로 하여 인체 인슐린 또는 그의 유도체를 제조하는 방법.
  2. 제1항에 있어서, 반응을 유기용매 부재하에 시행함을 특징으로 하는 방법.
  3. 제1항에 있어서, Des-PheB1 돼지 인슐린으로부터 Des-PheB1 인체 인슐린을 제조함을 특징으로 하는 방법.
  4. 제1항에 있어서, pH 4 내지 6에서 조작함을 특징으로 하는 방법.
  5. 제1항에 있어서, 돼지 인슐린의 유도체가 NαB1위치에 보호그룹을 수반하는 돼지 인슐린임을 특징으로 하는 방법.
  6. 제5항에 있어서, 보호그룹이 BOC 또는 DDZ임을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8200188A 1981-01-17 1982-01-18 인체 인슐린 및 그의 유도체의 제조방법 KR880001107B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813101382 DE3101382A1 (de) 1981-01-17 1981-01-17 "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
DE3101382.1 1981-01-17

Publications (2)

Publication Number Publication Date
KR830008995A true KR830008995A (ko) 1983-12-16
KR880001107B1 KR880001107B1 (ko) 1988-06-29

Family

ID=6122819

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8200188A KR880001107B1 (ko) 1981-01-17 1982-01-18 인체 인슐린 및 그의 유도체의 제조방법

Country Status (14)

Country Link
US (1) US4601852A (ko)
EP (1) EP0056951B1 (ko)
JP (1) JPS57138396A (ko)
KR (1) KR880001107B1 (ko)
AT (1) ATE13893T1 (ko)
AU (1) AU559235B2 (ko)
CA (1) CA1190496A (ko)
DE (2) DE3101382A1 (ko)
DK (1) DK149615B (ko)
ES (1) ES8301206A1 (ko)
FI (1) FI79860C (ko)
GR (1) GR74758B (ko)
IL (1) IL64789A (ko)
ZA (1) ZA82261B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
EP0367302A3 (en) * 1982-04-23 1991-06-19 Wako Pure Chemical Industries, Ltd. Process for semi-synthesis of human insulin, water-soluble cross-linked achromobacter protease i for use therein and a process for preparing the same
IT1189353B (it) * 1982-06-07 1988-02-04 Nordisk Insulinlab Procedimento per la preparazione di insulina umana e suoi esteri
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
US5106510A (en) * 1991-03-08 1992-04-21 Enviroguard, Inc. Combined filtration and fixation of heavy metals
DK0547544T3 (da) * 1991-12-18 1997-09-08 Hoechst Ag Fremgangsmåde til fremstilling af insulinholdige opløsninger.
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
HUP0004169A3 (en) 1997-10-24 2001-06-28 Lilly Co Eli Insoluble insulin compositions and process for production thereof
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
US6964561B2 (en) * 2002-04-23 2005-11-15 V System Composites, Inc. High-performance infusion system for VARTM fabrication
US20070108646A1 (en) * 2005-11-15 2007-05-17 Louderback Michael J Method of fabricating a composite structure with details

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
DE2460753A1 (de) * 1974-12-21 1976-06-24 Hoechst Ag Verfahren zur herstellung von humaninsulin
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Also Published As

Publication number Publication date
ES508657A0 (es) 1982-11-16
DK149615B (da) 1986-08-11
DE3101382A1 (de) 1982-09-02
GR74758B (ko) 1984-07-11
KR880001107B1 (ko) 1988-06-29
IL64789A (en) 1985-09-29
AU559235B2 (en) 1987-03-05
CA1190496A (en) 1985-07-16
AU7955482A (en) 1982-07-29
IL64789A0 (en) 1982-03-31
JPS57138396A (en) 1982-08-26
DE3264149D1 (en) 1985-07-25
DK16682A (da) 1982-07-18
FI79860B (fi) 1989-11-30
JPH0141317B2 (ko) 1989-09-05
ZA82261B (en) 1982-12-29
FI820117L (fi) 1982-07-18
ES8301206A1 (es) 1982-11-16
EP0056951A1 (de) 1982-08-04
ATE13893T1 (de) 1985-07-15
US4601852A (en) 1986-07-22
FI79860C (fi) 1990-03-12
EP0056951B1 (de) 1985-06-19

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