DE68910718D1 - Verfahren zur Herstellung von Taxol. - Google Patents

Verfahren zur Herstellung von Taxol.

Info

Publication number
DE68910718D1
DE68910718D1 DE89400934T DE68910718T DE68910718D1 DE 68910718 D1 DE68910718 D1 DE 68910718D1 DE 89400934 T DE89400934 T DE 89400934T DE 68910718 T DE68910718 T DE 68910718T DE 68910718 D1 DE68910718 D1 DE 68910718D1
Authority
DE
Germany
Prior art keywords
taxol
image
general formula
making
making taxol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89400934T
Other languages
English (en)
Other versions
DE68910718T2 (de
Inventor
Jean-Noel Denis
Andrew Elliot Greene
Daniel Guenard
Francoise Gueritte-Voegelein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9364991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68910718(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of DE68910718D1 publication Critical patent/DE68910718D1/de
Publication of DE68910718T2 publication Critical patent/DE68910718T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DE89400934T 1988-04-06 1989-04-05 Verfahren zur Herstellung von Taxol. Expired - Lifetime DE68910718T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8804512A FR2629818B1 (fr) 1988-04-06 1988-04-06 Procede de preparation du taxol

Publications (2)

Publication Number Publication Date
DE68910718D1 true DE68910718D1 (de) 1993-12-23
DE68910718T2 DE68910718T2 (de) 1994-03-31

Family

ID=9364991

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89400934T Expired - Lifetime DE68910718T2 (de) 1988-04-06 1989-04-05 Verfahren zur Herstellung von Taxol.

Country Status (10)

Country Link
US (1) US4924011A (de)
EP (1) EP0336840B1 (de)
JP (1) JPH0686440B2 (de)
AT (1) ATE97411T1 (de)
AU (1) AU620855B2 (de)
CA (1) CA1324611C (de)
DE (1) DE68910718T2 (de)
ES (1) ES2059794T3 (de)
FR (1) FR2629818B1 (de)
ZA (1) ZA892475B (de)

Families Citing this family (169)

* Cited by examiner, † Cited by third party
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FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
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US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
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US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
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FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
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US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
FR2671799B1 (fr) † 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
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FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
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US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
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US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
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US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
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US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
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US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
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US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
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US5451392A (en) * 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
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US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
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FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

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ES2059794T3 (es) 1994-11-16
FR2629818B1 (fr) 1990-11-16
AU3251989A (en) 1989-10-12
ATE97411T1 (de) 1993-12-15
JPH01305076A (ja) 1989-12-08
DE68910718T2 (de) 1994-03-31
US4924011A (en) 1990-05-08
JPH0686440B2 (ja) 1994-11-02
AU620855B2 (en) 1992-02-27
CA1324611C (fr) 1993-11-23
FR2629818A1 (fr) 1989-10-13
EP0336840A1 (de) 1989-10-11
EP0336840B1 (de) 1993-11-18
ZA892475B (en) 1989-12-27

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