DE3381980D1 - Verfahren zur halbsynthese von menschlichem insulin und dazu zu verwendende alkalische protease. - Google Patents
Verfahren zur halbsynthese von menschlichem insulin und dazu zu verwendende alkalische protease.Info
- Publication number
- DE3381980D1 DE3381980D1 DE8383104036T DE3381980T DE3381980D1 DE 3381980 D1 DE3381980 D1 DE 3381980D1 DE 8383104036 T DE8383104036 T DE 8383104036T DE 3381980 T DE3381980 T DE 3381980T DE 3381980 D1 DE3381980 D1 DE 3381980D1
- Authority
- DE
- Germany
- Prior art keywords
- synthesis
- semi
- human insulin
- alkaline protease
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6823882A JPS58187186A (ja) | 1982-04-23 | 1982-04-23 | 固定化酵素 |
JP12391782A JPS5914798A (ja) | 1982-07-16 | 1982-07-16 | ヒトインシユリンの半合成法 |
JP57162976A JPS5951789A (ja) | 1982-09-18 | 1982-09-18 | 安定化酵素 |
JP57169428A JPS5959189A (ja) | 1982-09-28 | 1982-09-28 | 新規なアルカリプロテア−ゼ |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3381980D1 true DE3381980D1 (de) | 1990-12-13 |
Family
ID=27464963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383104036T Expired - Fee Related DE3381980D1 (de) | 1982-04-23 | 1983-04-25 | Verfahren zur halbsynthese von menschlichem insulin und dazu zu verwendende alkalische protease. |
Country Status (3)
Country | Link |
---|---|
EP (2) | EP0092829B1 (de) |
DE (1) | DE3381980D1 (de) |
DK (2) | DK182483A (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5801022A (en) * | 1990-08-03 | 1998-09-01 | Vertex Pharmaceuticals, Incorporated | Method of producing a product with crosslinked crystals of thermolysin |
US5618710A (en) * | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
IE912767A1 (en) * | 1990-08-03 | 1992-02-12 | Vertex Pharma | Use of crosslinked crystals as a novel form of enzyme¹immobilization |
AU2091397A (en) * | 1996-03-12 | 1997-10-01 | Novo Nordisk A/S | Novel achromobacter lyticus protease variants |
US7396903B2 (en) * | 2001-11-19 | 2008-07-08 | Novo Nordisk A/S | Process for preparing insulin compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH538003A (fr) * | 1968-03-29 | 1973-01-31 | Anvar | Procédé pour l'obtention d'articles textiles porteurs d'enzymes |
US4251631A (en) * | 1978-02-23 | 1981-02-17 | Research Products Rehovot Ltd. | Cross-linked enzyme membrane |
JPS54119085A (en) * | 1978-03-09 | 1979-09-14 | Takeda Chem Ind Ltd | Alkaliprotease |
EP0017938B1 (de) * | 1979-04-13 | 1983-08-03 | Shionogi & Co., Ltd. | Verfahren zur Herstellung von B30-Threonin-Insulin |
DK147437A (en) * | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
WO1982004069A1 (en) * | 1981-05-20 | 1982-11-25 | Andresen Finn Hede | A process for the preparation of insulin derivatives |
JPS58501208A (ja) * | 1981-08-10 | 1983-07-28 | ノルデイスク インシユリンラボラトリユ−ム | インシユリン誘導体の製造法 |
CA1174623A (en) * | 1981-09-15 | 1984-09-18 | Finn H. Andresen | Process for preparing human insulin or b-30 esters thereof |
-
1983
- 1983-04-25 EP EP19830104036 patent/EP0092829B1/de not_active Expired
- 1983-04-25 EP EP19890123550 patent/EP0367302A3/de not_active Withdrawn
- 1983-04-25 DK DK182483A patent/DK182483A/da not_active Application Discontinuation
- 1983-04-25 DE DE8383104036T patent/DE3381980D1/de not_active Expired - Fee Related
-
1991
- 1991-08-29 DK DK152791A patent/DK152791D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0092829A2 (de) | 1983-11-02 |
DK182483A (da) | 1983-10-24 |
EP0092829B1 (de) | 1990-11-07 |
DK182483D0 (da) | 1983-04-25 |
DK152791A (da) | 1991-08-29 |
EP0367302A2 (de) | 1990-05-09 |
DK152791D0 (da) | 1991-08-29 |
EP0092829A3 (en) | 1985-08-21 |
EP0367302A3 (de) | 1991-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE29070T1 (de) | System und verfahren zur zellenauswahl. | |
DE3869490D1 (de) | Verfahren zur elektrochemischen behandlung von stoffen. | |
DE3854644T2 (de) | Verfahren und Vorrichtungen zur Zellenbestimmung. | |
DE3382442D1 (de) | Verfahren und vorrichtung zur dekomposition von schaedlichen materialien. | |
DE3382359D1 (de) | Verfahren zur kultivierung und isolierung von zellen. | |
DE3885834T2 (de) | Lötstelle und Verfahren zu ihrer Bewerkstelligung. | |
DE3280302D1 (de) | Eingebetteter fluessigkristall und verfahren. | |
ATE49952T1 (de) | Verfahren und vorrichtung zur herstellung von glasplatten. | |
DE3784855T2 (de) | Mischapparat und verfahren. | |
DE3851913D1 (de) | Superabsorbierende Zusammensetzung und Verfahren. | |
DE3577872D1 (de) | Fluessigkristallzusammensetzung, verfahren und vorrichtung. | |
DE3382699D1 (de) | Verfahren zur bildkontrasterhoehung und materialien dazu. | |
DE3482794D1 (de) | Verfahren und vorrichtung zur untersuchung von gebrauchsfertig vermischtem zement. | |
DE3789887T2 (de) | Verfahren und Apparat zur Prüfung von Gesamtblut. | |
DE3686662T2 (de) | Anordnungen und verfahren zur bearbeitung von optischen korrelatorspeichergeraeten. | |
DE3581983D1 (de) | Verfahren und anlage zur behandlung von anfallendem bau-mischschutt. | |
AT372977B (de) | Verfahren und einrichtung zur reduktion von oxidhaeltigen feinteiligen erzen | |
DE3675061D1 (de) | Verfahren und einrichtung zur pelletisierung von radioaktiven pulverigen abfaellen. | |
DE3853799D1 (de) | Mobile Vorrichtung zur Verbrennung von schwach radioaktivem Abfall. | |
DE3381980D1 (de) | Verfahren zur halbsynthese von menschlichem insulin und dazu zu verwendende alkalische protease. | |
DE3789589T2 (de) | Verfahren zur Volumenreduzierung von Abfallprodukten niedriger Radioaktivität. | |
DE3675633D1 (de) | Geraet und verfahren zur herstellung von steckverbindern. | |
DE3483173D1 (de) | Verfahren und vorrichtung zur verbrennung von materialien. | |
DE3774804D1 (de) | Elektrophotographisches verfahren und geraet. | |
DE3785796D1 (de) | Verfahren und einrichtung zur behandlung von abfallstoffen in einer schnellgaerungsvorrichtung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |