DK152791A - Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved - Google Patents

Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved Download PDF

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Publication number
DK152791A
DK152791A DK152791A DK152791A DK152791A DK 152791 A DK152791 A DK 152791A DK 152791 A DK152791 A DK 152791A DK 152791 A DK152791 A DK 152791A DK 152791 A DK152791 A DK 152791A
Authority
DK
Denmark
Prior art keywords
semisynthesis
procedure
human insulin
achromobacter protease
achromobacter
Prior art date
Application number
DK152791A
Other languages
English (en)
Other versions
DK152791D0 (da
Inventor
Masami Soejima
Takeharu Masaki
Jyoji Nagaoka
Yoshitsugu Sakata
Akinori Shintani
Nobuaki Minamii
Tetsuya Matsuo
Haruhiko Sugiyama
Nobuyuki Tokioka
Hideya Suzuki
Original Assignee
Wako Pure Chem Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6823882A external-priority patent/JPS58187186A/ja
Priority claimed from JP12391782A external-priority patent/JPS5914798A/ja
Priority claimed from JP57162976A external-priority patent/JPS5951789A/ja
Priority claimed from JP57169428A external-priority patent/JPS5959189A/ja
Application filed by Wako Pure Chem Ind Ltd filed Critical Wako Pure Chem Ind Ltd
Publication of DK152791A publication Critical patent/DK152791A/da
Publication of DK152791D0 publication Critical patent/DK152791D0/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
DK152791A 1982-04-23 1991-08-29 Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved DK152791D0 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP6823882A JPS58187186A (ja) 1982-04-23 1982-04-23 固定化酵素
JP12391782A JPS5914798A (ja) 1982-07-16 1982-07-16 ヒトインシユリンの半合成法
JP57162976A JPS5951789A (ja) 1982-09-18 1982-09-18 安定化酵素
JP57169428A JPS5959189A (ja) 1982-09-28 1982-09-28 新規なアルカリプロテア−ゼ

Publications (2)

Publication Number Publication Date
DK152791A true DK152791A (da) 1991-08-29
DK152791D0 DK152791D0 (da) 1991-08-29

Family

ID=27464963

Family Applications (2)

Application Number Title Priority Date Filing Date
DK182483A DK182483A (da) 1982-04-23 1983-04-25 Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved
DK152791A DK152791D0 (da) 1982-04-23 1991-08-29 Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK182483A DK182483A (da) 1982-04-23 1983-04-25 Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved

Country Status (3)

Country Link
EP (2) EP0367302A3 (da)
DE (1) DE3381980D1 (da)
DK (2) DK182483A (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG70966A1 (en) * 1990-08-03 2000-03-21 Vertex Pharma Use of crosslinked crystals as a novel form of enzyme immobilization
US5618710A (en) * 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
US5801022A (en) * 1990-08-03 1998-09-01 Vertex Pharmaceuticals, Incorporated Method of producing a product with crosslinked crystals of thermolysin
WO1997033984A1 (en) * 1996-03-12 1997-09-18 Novo Nordisk A/S Novel achromobacter lyticus protease variants
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH564031A5 (da) * 1968-03-29 1975-07-15 Anvar
US4251631A (en) * 1978-02-23 1981-02-17 Research Products Rehovot Ltd. Cross-linked enzyme membrane
JPS54119085A (en) * 1978-03-09 1979-09-14 Takeda Chem Ind Ltd Alkaliprotease
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
WO1983001074A1 (en) * 1981-09-15 1983-03-31 Andresen, Finn, Hede Enzymatic preparation of human insulin or b-30 esters thereof
WO1982004069A1 (en) * 1981-05-20 1982-11-25 Andresen Finn Hede A process for the preparation of insulin derivatives
JPS58501208A (ja) * 1981-08-10 1983-07-28 ノルデイスク　インシユリンラボラトリユ−ム インシユリン誘導体の製造法

Also Published As

Publication number Publication date
EP0092829B1 (en) 1990-11-07
EP0092829A2 (en) 1983-11-02
EP0367302A2 (en) 1990-05-09
DK182483D0 (da) 1983-04-25
EP0092829A3 (en) 1985-08-21
DK152791D0 (da) 1991-08-29
EP0367302A3 (en) 1991-06-19
DE3381980D1 (de) 1990-12-13
DK182483A (da) 1983-10-24

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