JPS57118546A - Insulin derivative - Google Patents

Insulin derivative

Info

Publication number
JPS57118546A
JPS57118546A JP56175029A JP17502981A JPS57118546A JP S57118546 A JPS57118546 A JP S57118546A JP 56175029 A JP56175029 A JP 56175029A JP 17502981 A JP17502981 A JP 17502981A JP S57118546 A JPS57118546 A JP S57118546A
Authority
JP
Japan
Prior art keywords
insulin
protecting group
compound
pig
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56175029A
Other languages
Japanese (ja)
Other versions
JPS6246560B2 (en
Inventor
Kazuyuki Morihara
Tatsu Oka
Takeshi Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP56175029A priority Critical patent/JPS57118546A/en
Publication of JPS57118546A publication Critical patent/JPS57118546A/en
Priority to JP61266446A priority patent/JPS62116597A/en
Publication of JPS6246560B2 publication Critical patent/JPS6246560B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The insulin derivative of formulaI(R1 is H or hydroxy-protecting group; R2 is carboxy-protecting group; R3 is guanidino-protecting group).
EXAMPLE: Pig-originated[B22-Arg(1,2-dihydroxycyclohexylene), B30-Thr-t-butyl ester]-insulin.
USE: Intermdiate for the synthesis of remedy for diabetes. It can be converted to human insulin by removing the protecting groups. Useful for the synthesis of human insulin from pig insulin.
PROCESS: The compound of formulaIis prepared by reacting the compound of formula II with the L-threonine derivative of formula III in the presence of trypsin or an enzyme having similar activity to trypsin. The compound of formula II can be obtained e.g. by introducing a protecting group to the guanidino group of Arg at 22-position of the B-chain of pig insulin, and severing the 30- position amino acid with an enzyme.
COPYRIGHT: (C)1982,JPO&Japio
JP56175029A 1981-10-30 1981-10-30 Insulin derivative Granted JPS57118546A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP56175029A JPS57118546A (en) 1981-10-30 1981-10-30 Insulin derivative
JP61266446A JPS62116597A (en) 1981-10-30 1986-11-07 Production of human insulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56175029A JPS57118546A (en) 1981-10-30 1981-10-30 Insulin derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP4570979A Division JPS55138392A (en) 1979-04-13 1979-04-13 Semisynthesis of insulin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP61266446A Division JPS62116597A (en) 1981-10-30 1986-11-07 Production of human insulin

Publications (2)

Publication Number Publication Date
JPS57118546A true JPS57118546A (en) 1982-07-23
JPS6246560B2 JPS6246560B2 (en) 1987-10-02

Family

ID=15988967

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56175029A Granted JPS57118546A (en) 1981-10-30 1981-10-30 Insulin derivative

Country Status (1)

Country Link
JP (1) JPS57118546A (en)

Also Published As

Publication number Publication date
JPS6246560B2 (en) 1987-10-02

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