NO894539L - Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater. - Google Patents

Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater.

Info

Publication number
NO894539L
NO894539L NO89894539A NO894539A NO894539L NO 894539 L NO894539 L NO 894539L NO 89894539 A NO89894539 A NO 89894539A NO 894539 A NO894539 A NO 894539A NO 894539 L NO894539 L NO 894539L
Authority
NO
Norway
Prior art keywords
uriden
halomethylidene
guanosin
ethynylcytidine
ethenylidene
Prior art date
Application number
NO89894539A
Other languages
English (en)
Other versions
NO172240B (no
NO894539D0 (no
NO172240C (no
Inventor
James Ray Mccarthy
Michael Louis Edwards
Donald Paul Matthews
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO894539D0 publication Critical patent/NO894539D0/no
Publication of NO894539L publication Critical patent/NO894539L/no
Publication of NO172240B publication Critical patent/NO172240B/no
Publication of NO172240C publication Critical patent/NO172240C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
NO894539A 1988-11-15 1989-11-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater NO172240C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27147988A 1988-11-15 1988-11-15

Publications (4)

Publication Number Publication Date
NO894539D0 NO894539D0 (no) 1989-11-14
NO894539L true NO894539L (no) 1990-05-16
NO172240B NO172240B (no) 1993-03-15
NO172240C NO172240C (no) 1993-06-23

Family

ID=23035764

Family Applications (1)

Application Number Title Priority Date Filing Date
NO894539A NO172240C (no) 1988-11-15 1989-11-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater

Country Status (19)

Country Link
EP (1) EP0372268B1 (no)
JP (1) JP2802947B2 (no)
KR (1) KR0144865B1 (no)
CN (1) CN1022248C (no)
AR (1) AR247891A1 (no)
AT (1) ATE105297T1 (no)
AU (1) AU621160B2 (no)
CA (1) CA2002648C (no)
DE (1) DE68915128T2 (no)
DK (1) DK171844B1 (no)
ES (1) ES2056180T3 (no)
FI (1) FI92588C (no)
HU (3) HU205134B (no)
IE (1) IE63563B1 (no)
IL (1) IL92293A (no)
NO (1) NO172240C (no)
NZ (1) NZ231365A (no)
PT (1) PT92309B (no)
ZA (1) ZA898567B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (en) * 1992-04-23 1993-11-11 Yoshitomi Pharmaceutical Industries, Ltd. 2'-methylidenenucleoside compound and pharmaceutical use thereof
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
HU217963B (hu) * 1992-05-12 2000-05-28 Merrell Dow Pharmaceuticals Inc. Eljárás ribonukleotid-reduktáz inhibitorok előállítására
EP0671918B1 (en) * 1992-12-03 1997-05-28 Merrell Pharmaceuticals Inc. Compositions containing acyclovir-like compounds and 2'-vinyl substituted nucleoside analogs for the treatment of viral infections
DE69421721T2 (de) * 1994-01-07 2000-04-27 Merrell Pharma Inc (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydrat
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
EP0770621A4 (en) * 1994-07-12 1998-01-28 Yamasa Corp 2'-DESOXY-2 '- (METHYLIDENE SUBSTITUTED OR NON-SUBSTITUTED) -4'-THIONUCLEOSIDE
WO2003026675A1 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) * 2004-10-27 2008-05-21 北京东华康明生物科技有限公司 （反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9732111B2 (en) * 2012-11-19 2017-08-15 Merck Sharp & Dohme Corp. 2′-alkynyl substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2018092107A1 (en) * 2016-11-21 2018-05-24 Munisekhar Medasani Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도

Also Published As

Publication number Publication date
CA2002648C (en) 2000-02-29
HU895900D0 (en) 1990-02-28
DE68915128D1 (de) 1994-06-09
AU621160B2 (en) 1992-03-05
NO172240B (no) 1993-03-15
ES2056180T3 (es) 1994-10-01
FI92588B (fi) 1994-08-31
CN1022248C (zh) 1993-09-29
NZ231365A (en) 1992-08-26
JPH02178272A (ja) 1990-07-11
AR247891A1 (es) 1995-04-28
DK570089D0 (da) 1989-11-14
NO894539D0 (no) 1989-11-14
PT92309A (pt) 1990-05-31
AU4461189A (en) 1990-05-24
FI92588C (fi) 1994-12-12
DE68915128T2 (de) 1994-08-25
CN1042715A (zh) 1990-06-06
HU00045A9 (en) 1995-01-30
CA2002648A1 (en) 1990-05-15
FI895417A0 (fi) 1989-11-14
JP2802947B2 (ja) 1998-09-24
ZA898567B (en) 1990-08-29
IE63563B1 (en) 1995-05-17
EP0372268A1 (en) 1990-06-13
HU205134B (en) 1992-03-30
DK570089A (da) 1990-05-16
HU210343A9 (en) 1995-03-28
IL92293A (en) 1995-01-24
PT92309B (pt) 1996-06-28
KR0144865B1 (ko) 1998-07-01
DK171844B1 (da) 1997-06-30
IL92293A0 (en) 1990-07-26
IE893651L (en) 1990-05-15
EP0372268B1 (en) 1994-05-04
KR900007833A (ko) 1990-06-02
ATE105297T1 (de) 1994-05-15
HUT51642A (en) 1990-05-28
NO172240C (no) 1993-06-23

Similar Documents

Publication Publication Date Title
NO892083D0 (no) Fremgangsmaate for fremstilling av arylmetylenyl-derivaterav tiazolidinoner, imidazolidinoner og oksazolidinoner.
NO894539D0 (no) Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater.
NO891951D0 (no) Fremgangsmaate for fremstilling av nye hydroksamat-derivater.
NO892936D0 (no) Fremgangsmaate for fremstilling av furanderivater.
MX9203459A (es) Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.
NO893826L (no) Fremgangsmaate for fremstilling av 2'-halomethyliden, 2'-ethenyliden og 2'-ethenyladenosinderivater.
NO901813L (no) Fremgangsmaate for fremstilling av nye tieno-triazolo-diazepin-derivater.
NO900643L (no) Fremgangsmaate for fremstilling og anvendelse av 2,3,23-trihydroksi-urs-12-ener og deres derivater.
NO891588D0 (no) Fremgangsmaate for fremstilling av fosfonoalkylpurinderivater.
NO903347D0 (no) Fremgangsmaate for fremstilling av 14,17alfa-ethano- og ethanooestratriener.
NO892977L (no) Fremgangsmaate for fremstilling av nye s-adenosylmethionin-derivater.
NO891985D0 (no) Fremgangsmaate for fremstilling av dibenzotiofen- og tioxanten-derivater.
NO921086D0 (no) Fremgangsmaate for fremstilling og anvendelse av substituerte 2',3'-didesoksy-5-trifluormetyluridiner
NO891025L (no) Fremgangsmaate for fremstilling av nye, terapeutisk aktivesialosylglycerider.
NO904108L (no) Fremstilling av 2,6-dioksypiperidinderivater.
NO901732D0 (no) Fremgangsmaate for fremstilling av 4-alkoksyalkyl-4-aminofenylpiperidiner og derivater derav.
NO894037L (no) Fremgangsmaate for fremstilling av nye 2-metoksykarbonyl-substituerte n,n'-di(trimetoksybenzoyl) piperaziner.
NO894707L (no) Fremgangsmaate for fremstilling av benzoksazinderivater.
NO891987D0 (no) Fremgangsmaate for fremstilling av n-substituerte fenyltioaniliner, fenylsulfinylaniliner og fenylsulfonylaniliner.
NO893291D0 (no) Fremgangsmaate for fremstilling av nye benzasolderivater og farmasoeytiske preparater derav.
NO894476L (no) Derivater av 2,3-difluorhydrokinon.
NO912279L (no) Fremgangsmaate for fremstilling og anvendelse av eksplosjonssikre 1-dimetylamino-3-dimetylimino-2-arylprop-1-en-salter.
NO902293L (no) Fremgangsmaate for fremstilling av nye tiazepinderivater.
NO913388D0 (no) Framgangsmaate for framstilling av 1,5-benzotiazepinderivater.
NO883525D0 (no) Framgangsmaate for framstilling av 1,5-benzotiazepinderivater.

Legal Events

Date Code Title Description
MK1K Patent expired