NO921086D0 - Fremgangsmaate for fremstilling og anvendelse av substituerte 2',3'-didesoksy-5-trifluormetyluridiner - Google Patents

Fremgangsmaate for fremstilling og anvendelse av substituerte 2',3'-didesoksy-5-trifluormetyluridiner

Info

Publication number
NO921086D0
NO921086D0 NO921086A NO921086A NO921086D0 NO 921086 D0 NO921086 D0 NO 921086D0 NO 921086 A NO921086 A NO 921086A NO 921086 A NO921086 A NO 921086A NO 921086 D0 NO921086 D0 NO 921086D0
Authority
NO
Norway
Prior art keywords
trifluormytyluridines
didesoxy
substituted
procedure
preparation
Prior art date
Application number
NO921086A
Other languages
English (en)
Other versions
NO921086L (no
Inventor
Dieter Haebich
Rainer Neumann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO921086D0 publication Critical patent/NO921086D0/no
Publication of NO921086L publication Critical patent/NO921086L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO92921086A 1991-04-05 1992-03-19 Fremgangsmaate for fremstilling og anvendelse av substituerte 2',3'-didesoksy-5-trifluormetyluridiner NO921086L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4110977A DE4110977A1 (de) 1991-04-05 1991-04-05 Substituierte 2',3'-didesoxy-5-trifluormethyluridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
NO921086D0 true NO921086D0 (no) 1992-03-19
NO921086L NO921086L (no) 1992-10-06

Family

ID=6428857

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92921086A NO921086L (no) 1991-04-05 1992-03-19 Fremgangsmaate for fremstilling og anvendelse av substituerte 2',3'-didesoksy-5-trifluormetyluridiner

Country Status (15)

Country Link
EP (1) EP0507188A1 (no)
JP (1) JPH05148261A (no)
KR (1) KR920019813A (no)
CN (1) CN1065462A (no)
AU (1) AU640860B2 (no)
CA (1) CA2064916A1 (no)
CS (1) CS92092A3 (no)
DE (1) DE4110977A1 (no)
FI (1) FI921456A (no)
HU (1) HUT60748A (no)
IE (1) IE921083A1 (no)
IL (1) IL101482A0 (no)
NO (1) NO921086L (no)
NZ (1) NZ242205A (no)
TW (1) TW205043B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050846C (zh) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 一种抗肿瘤抗生素云南霉素及其制备方法
EP1387850A2 (en) 2001-05-18 2004-02-11 Rakesh Kumar Antiviral nucleosides
CN100334100C (zh) * 2004-01-17 2007-08-29 杭州富邦生物制药有限公司 5-三氟甲基-2’-脱氧尿苷的合成方法
JP4603274B2 (ja) * 2004-02-24 2010-12-22 三井化学株式会社 2’−デオキシ−5−トリフルオロメチルウリジンの製造方法
WO2009119785A1 (ja) * 2008-03-28 2009-10-01 浜理薬品工業株式会社 エチニルチミジン化合物の精製方法
JP5485140B2 (ja) * 2008-04-10 2014-05-07 浜理薬品工業株式会社 5−メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048877A1 (de) * 1980-12-23 1982-07-08 Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri Pyrimidinnucleosid-phosphonate, verfahren zur herstellung und sie enthaltende mittel
EP0206497B1 (en) * 1985-05-15 1994-07-20 The Wellcome Foundation Limited Therapeutic nucleosides and their preparation
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
CA1327000C (en) * 1987-08-07 1994-02-15 David L.J. Tyrrell Antiviral therapy for hepatitis b
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
SE8802173D0 (sv) * 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
JPH04501854A (ja) * 1989-05-15 1992-04-02 アメリカ合衆国 肝炎の治療方法
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides

Also Published As

Publication number Publication date
JPH05148261A (ja) 1993-06-15
CA2064916A1 (en) 1992-10-06
KR920019813A (ko) 1992-11-20
FI921456A (fi) 1992-10-06
HUT60748A (en) 1992-10-28
IE921083A1 (en) 1992-10-07
IL101482A0 (en) 1992-12-30
AU1219092A (en) 1992-10-08
NZ242205A (en) 1993-04-28
HU9201117D0 (en) 1992-06-29
TW205043B (no) 1993-05-01
AU640860B2 (en) 1993-09-02
DE4110977A1 (de) 1992-10-08
NO921086L (no) 1992-10-06
CN1065462A (zh) 1992-10-21
FI921456A0 (fi) 1992-04-02
EP0507188A1 (de) 1992-10-07
CS92092A3 (en) 1992-12-16

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