AU1219092A - Substituted 2', 3'-dideoxy-5-trifluoromethyluridines, processes for their preparation and their use in medicaments - Google Patents

Substituted 2', 3'-dideoxy-5-trifluoromethyluridines, processes for their preparation and their use in medicaments

Info

Publication number
AU1219092A
AU1219092A AU12190/92A AU1219092A AU1219092A AU 1219092 A AU1219092 A AU 1219092A AU 12190/92 A AU12190/92 A AU 12190/92A AU 1219092 A AU1219092 A AU 1219092A AU 1219092 A AU1219092 A AU 1219092A
Authority
AU
Australia
Prior art keywords
trifluoromethyluridines
dideoxy
medicaments
substituted
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU12190/92A
Other versions
AU640860B2 (en
Inventor
Dieter Habich
Rainer Neumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU1219092A publication Critical patent/AU1219092A/en
Application granted granted Critical
Publication of AU640860B2 publication Critical patent/AU640860B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU12190/92A 1991-04-05 1992-03-10 Substituted 2', 3'-dideoxy-5-trifluoromethyluridines, processes for their preparation and their use in medicaments Ceased AU640860B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4110977A DE4110977A1 (en) 1991-04-05 1991-04-05 SUBSTITUTED 2 ', 3'-DIDESOXY-5-TRIFLUOROMETHYLURIDINES, METHOD OF THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS
DE4110977 1991-04-05

Publications (2)

Publication Number Publication Date
AU1219092A true AU1219092A (en) 1992-10-08
AU640860B2 AU640860B2 (en) 1993-09-02

Family

ID=6428857

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12190/92A Ceased AU640860B2 (en) 1991-04-05 1992-03-10 Substituted 2', 3'-dideoxy-5-trifluoromethyluridines, processes for their preparation and their use in medicaments

Country Status (15)

Country Link
EP (1) EP0507188A1 (en)
JP (1) JPH05148261A (en)
KR (1) KR920019813A (en)
CN (1) CN1065462A (en)
AU (1) AU640860B2 (en)
CA (1) CA2064916A1 (en)
CS (1) CS92092A3 (en)
DE (1) DE4110977A1 (en)
FI (1) FI921456A (en)
HU (1) HUT60748A (en)
IE (1) IE921083A1 (en)
IL (1) IL101482A0 (en)
NO (1) NO921086L (en)
NZ (1) NZ242205A (en)
TW (1) TW205043B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050846C (en) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 Antitumor antibiotic-Yunnan-mycin
EP2322534A1 (en) 2001-05-18 2011-05-18 Rakesh Kumar Antiviral nucleosides
CN100334100C (en) * 2004-01-17 2007-08-29 杭州富邦生物制药有限公司 Method for synthesizing 5-trifluoro methyl-2'-desugarized uridine
JP4603274B2 (en) * 2004-02-24 2010-12-22 三井化学株式会社 Process for producing 2'-deoxy-5-trifluoromethyluridine
JP5485138B2 (en) * 2008-03-28 2014-05-07 浜理薬品工業株式会社 Method for purifying ethynylthymidine compounds
JP5485140B2 (en) 2008-04-10 2014-05-07 浜理薬品工業株式会社 Process for producing ethynylthymidine compound starting from 5-methyluridine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048877A1 (en) * 1980-12-23 1982-07-08 Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri Pyrimidine nucleoside phosphonate derivs. - useful as antiviral agents
PT82580B (en) * 1985-05-15 1989-01-17 Wellcome Found Process for the preparation of 2 ', 3'-DIDESOXINUCLEOSIDOS AND OF PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
DK167377B1 (en) * 1985-09-17 1993-10-25 Wellcome Found 3'-AZIDOPYRIMIDINE NUCLEOSIDES OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF USED FOR TREATMENT OR PROPHYLAXY FOR A HUMAN RETROVIRUS INFECTION
CA1327000C (en) * 1987-08-07 1994-02-15 David L.J. Tyrrell Antiviral therapy for hepatitis b
SE8704298D0 (en) * 1987-11-03 1987-11-03 Astra Ab COMPOUNDS FOR USE IN THERAPY
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
SE8802173D0 (en) * 1988-06-10 1988-06-10 Astra Ab PYRIMIDINE DERIVATIVES
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
AU5659990A (en) * 1989-05-15 1990-12-18 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method of treatment of hepatitis
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor

Also Published As

Publication number Publication date
IL101482A0 (en) 1992-12-30
CA2064916A1 (en) 1992-10-06
DE4110977A1 (en) 1992-10-08
JPH05148261A (en) 1993-06-15
NO921086D0 (en) 1992-03-19
FI921456A0 (en) 1992-04-02
AU640860B2 (en) 1993-09-02
EP0507188A1 (en) 1992-10-07
FI921456A (en) 1992-10-06
CN1065462A (en) 1992-10-21
HU9201117D0 (en) 1992-06-29
CS92092A3 (en) 1992-12-16
IE921083A1 (en) 1992-10-07
HUT60748A (en) 1992-10-28
TW205043B (en) 1993-05-01
KR920019813A (en) 1992-11-20
NZ242205A (en) 1993-04-28
NO921086L (en) 1992-10-06

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