CS92092A3 - Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments - Google Patents

Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments

Info

Publication number
CS92092A3
CS92092A3 CS92920A CS92092A CS92092A3 CS 92092 A3 CS92092 A3 CS 92092A3 CS 92920 A CS92920 A CS 92920A CS 92092 A CS92092 A CS 92092A CS 92092 A3 CS92092 A3 CS 92092A3
Authority
CS
Czechoslovakia
Prior art keywords
uridines
dideoxy
medicaments
trifluoromethyl
substituted
Prior art date
Application number
CS92920A
Other languages
Czech (cs)
Inventor
Dieter Dr Habich
Rainer Dr Neumann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CS92092A3 publication Critical patent/CS92092A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
CS92920A 1991-04-05 1992-03-26 Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments CS92092A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4110977A DE4110977A1 (en) 1991-04-05 1991-04-05 SUBSTITUTED 2 ', 3'-DIDESOXY-5-TRIFLUOROMETHYLURIDINES, METHOD OF THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
CS92092A3 true CS92092A3 (en) 1992-12-16

Family

ID=6428857

Family Applications (1)

Application Number Title Priority Date Filing Date
CS92920A CS92092A3 (en) 1991-04-05 1992-03-26 Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments

Country Status (15)

Country Link
EP (1) EP0507188A1 (en)
JP (1) JPH05148261A (en)
KR (1) KR920019813A (en)
CN (1) CN1065462A (en)
AU (1) AU640860B2 (en)
CA (1) CA2064916A1 (en)
CS (1) CS92092A3 (en)
DE (1) DE4110977A1 (en)
FI (1) FI921456A (en)
HU (1) HUT60748A (en)
IE (1) IE921083A1 (en)
IL (1) IL101482A0 (en)
NO (1) NO921086L (en)
NZ (1) NZ242205A (en)
TW (1) TW205043B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050846C (en) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 Antitumor antibiotic-Yunnan-mycin
CA2826505A1 (en) 2001-05-18 2002-11-28 Rakesh Kumar Antiviral nucleosides
CN100334100C (en) * 2004-01-17 2007-08-29 杭州富邦生物制药有限公司 Method for synthesizing 5-trifluoro methyl-2'-desugarized uridine
JP4603274B2 (en) * 2004-02-24 2010-12-22 三井化学株式会社 Process for producing 2'-deoxy-5-trifluoromethyluridine
WO2009119785A1 (en) * 2008-03-28 2009-10-01 浜理薬品工業株式会社 Method for purifying ethynylthymidine compound
EP2277878B1 (en) 2008-04-10 2014-09-17 Hamari Chemicals, Ltd. Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048877A1 (en) * 1980-12-23 1982-07-08 Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri Pyrimidine nucleoside phosphonate derivs. - useful as antiviral agents
HU196607B (en) * 1985-05-15 1988-12-28 Wellcome Found Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds
ATE190064T1 (en) * 1985-09-17 2000-03-15 Wellcome Found COMBINATION THERAPEUTIC NUCLEOSIDES WITH OTHER THERAPEUTICALLY EFFECTIVE COMPONENTS.
CA1327000C (en) * 1987-08-07 1994-02-15 David L.J. Tyrrell Antiviral therapy for hepatitis b
SE8704298D0 (en) * 1987-11-03 1987-11-03 Astra Ab COMPOUNDS FOR USE IN THERAPY
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
SE8802173D0 (en) * 1988-06-10 1988-06-10 Astra Ab PYRIMIDINE DERIVATIVES
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
CA2055433A1 (en) * 1989-05-15 1990-11-16 Jay H. Hoofnagle Method of treatment of hepatitis
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor

Also Published As

Publication number Publication date
IL101482A0 (en) 1992-12-30
EP0507188A1 (en) 1992-10-07
CN1065462A (en) 1992-10-21
JPH05148261A (en) 1993-06-15
CA2064916A1 (en) 1992-10-06
HUT60748A (en) 1992-10-28
AU640860B2 (en) 1993-09-02
IE921083A1 (en) 1992-10-07
FI921456A0 (en) 1992-04-02
NO921086L (en) 1992-10-06
DE4110977A1 (en) 1992-10-08
KR920019813A (en) 1992-11-20
NZ242205A (en) 1993-04-28
NO921086D0 (en) 1992-03-19
AU1219092A (en) 1992-10-08
FI921456A (en) 1992-10-06
HU9201117D0 (en) 1992-06-29
TW205043B (en) 1993-05-01

Similar Documents

Publication Publication Date Title
OA09964A (en) 1,5- Benzodiazepine derivatives and their use in medicine
PH25126A (en) 1,5-diaryl-3-substituted pyrazoles pharmaceutical compositions and use
EP0518818A3 (en) Arylethers, their manufacture and use as medicament
IL100741A0 (en) N-phenylsulfonyl-n'-pyrimidinyl-,-n'-triazinyl-and-n'-triazolylureas and-thioureas,their preparation and their use as herbicides
IL101530A0 (en) 3,4,n-trisubstituted-4,5-dihydro-1h-pyrazole-1-carboxamides and their use as insecticides
ZA929127B (en) Quinoline-3-carboxamides their manufacture and use
CS246191A3 (en) Corticoid-17-alkylcarbonates, being substituted in position 17, process of their preparation and medicaments comprising them
ZA917853B (en) 2-aminopyrimidine-4-carboxamide derivatives,their preparation and their use in therapy
CS202292A3 (en) Novel pyrrolopyrazines, process of their preparation and medicaments based thereon
CS92092A3 (en) Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments
ZA924127B (en) New hetaryloxy-beta-carbolines,their production and use in pharmaceutical agents
ZA932576B (en) 1,2,4-benzothiadiazine-3-carboxylic acid derivatives, their preparation and their use
ZA897532B (en) Basic 4-aryl-dhp amides,processes for their preparation and their use in medicaments
EP0701557A4 (en) Lavendamycin analogs, their use and preparation
EP0442086A3 (en) Graftcopolymers, their preparation and their use
NZ229274A (en) 1,2-dithiol-3-thion-s-oxides and liver-protective medicaments
EP0416754A3 (en) A novel substituted pyrazine, formulations thereof and use in medicine
PH27414A (en) 1,2,4-oxadiazolyl-phenoxy-alkylisoxazoles and their use as antiviral agents
ZA93639B (en) New 4-cinnolinyl- and 4 naphthyridinyl-dihydropyridines, processes for their use in medicaments.
ZA911956B (en) 9-chlor-prostaglandin-beta-cyclodextrin-clathrates and their use as medicinal substances
IL97859A0 (en) 1,5-benzothiazepinone derivatives,their preparation and pharmaceutical use
ZA927154B (en) Indolesulphonamide-substituted dihydropyridines, processes for their preparation and their use in medicaments.
EP0583698A3 (en) Deoxycyclitol derivatives, process for their preparation and their use in medicaments.
JPS6422876A (en) 8 alpha-acylaminoergoline, manufacture and medicine
PH30808A (en) 2-Amino-4-heteroaryl-1,-4-2dihydropyridines and their use in medicaments.