FI921456A0 - SUBSTITUTES 2 ', 3'-DIDESOXY-5-TRIFLUORMETHYLURIDINE FOERFARANDEN FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING I LAEKEMEDEL. - Google Patents

SUBSTITUTES 2 ', 3'-DIDESOXY-5-TRIFLUORMETHYLURIDINE FOERFARANDEN FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING I LAEKEMEDEL.

Info

Publication number
FI921456A0
FI921456A0 FI921456A FI921456A FI921456A0 FI 921456 A0 FI921456 A0 FI 921456A0 FI 921456 A FI921456 A FI 921456A FI 921456 A FI921456 A FI 921456A FI 921456 A0 FI921456 A0 FI 921456A0
Authority
FI
Finland
Prior art keywords
deras
trifluormethyluridine
laekemedel
didesoxy
substitutes
Prior art date
Application number
FI921456A
Other languages
Finnish (fi)
Other versions
FI921456A (en
Inventor
Dieter Haebich
Rainer Neumann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI921456A0 publication Critical patent/FI921456A0/en
Publication of FI921456A publication Critical patent/FI921456A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI921456A 1991-04-05 1992-04-02 SUBSTITUTES FOR 2 ', 3'-DIDESOXY-5-TRIFLUORMETHYLURIDINE, FORM OF FOUNDATION FOR THE FRAMEWORK OF CHARACTERISTICS FI921456A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4110977A DE4110977A1 (en) 1991-04-05 1991-04-05 SUBSTITUTED 2 ', 3'-DIDESOXY-5-TRIFLUOROMETHYLURIDINES, METHOD OF THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
FI921456A0 true FI921456A0 (en) 1992-04-02
FI921456A FI921456A (en) 1992-10-06

Family

ID=6428857

Family Applications (1)

Application Number Title Priority Date Filing Date
FI921456A FI921456A (en) 1991-04-05 1992-04-02 SUBSTITUTES FOR 2 ', 3'-DIDESOXY-5-TRIFLUORMETHYLURIDINE, FORM OF FOUNDATION FOR THE FRAMEWORK OF CHARACTERISTICS

Country Status (15)

Country Link
EP (1) EP0507188A1 (en)
JP (1) JPH05148261A (en)
KR (1) KR920019813A (en)
CN (1) CN1065462A (en)
AU (1) AU640860B2 (en)
CA (1) CA2064916A1 (en)
CS (1) CS92092A3 (en)
DE (1) DE4110977A1 (en)
FI (1) FI921456A (en)
HU (1) HUT60748A (en)
IE (1) IE921083A1 (en)
IL (1) IL101482A0 (en)
NO (1) NO921086L (en)
NZ (1) NZ242205A (en)
TW (1) TW205043B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050846C (en) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 Antitumor antibiotic-Yunnan-mycin
WO2002094844A2 (en) * 2001-05-18 2002-11-28 Rakesh Kumar Antiviral nucleosides
CN100334100C (en) * 2004-01-17 2007-08-29 杭州富邦生物制药有限公司 Method for synthesizing 5-trifluoro methyl-2'-desugarized uridine
JP4603274B2 (en) * 2004-02-24 2010-12-22 三井化学株式会社 Process for producing 2'-deoxy-5-trifluoromethyluridine
WO2009119785A1 (en) * 2008-03-28 2009-10-01 浜理薬品工業株式会社 Method for purifying ethynylthymidine compound
EP2277878B1 (en) 2008-04-10 2014-09-17 Hamari Chemicals, Ltd. Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048877A1 (en) * 1980-12-23 1982-07-08 Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri Pyrimidine nucleoside phosphonate derivs. - useful as antiviral agents
AU591125B2 (en) * 1985-05-15 1989-11-30 Wellcome Foundation Limited, The Therapeutic nucleosides
DK167377B1 (en) * 1985-09-17 1993-10-25 Wellcome Found 3'-AZIDOPYRIMIDINE NUCLEOSIDES OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF USED FOR TREATMENT OR PROPHYLAXY FOR A HUMAN RETROVIRUS INFECTION
CA1327000C (en) * 1987-08-07 1994-02-15 David L.J. Tyrrell Antiviral therapy for hepatitis b
SE8704298D0 (en) * 1987-11-03 1987-11-03 Astra Ab COMPOUNDS FOR USE IN THERAPY
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
SE8802173D0 (en) * 1988-06-10 1988-06-10 Astra Ab PYRIMIDINE DERIVATIVES
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
CA2055433A1 (en) * 1989-05-15 1990-11-16 Jay H. Hoofnagle Method of treatment of hepatitis
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides

Also Published As

Publication number Publication date
KR920019813A (en) 1992-11-20
TW205043B (en) 1993-05-01
AU1219092A (en) 1992-10-08
CA2064916A1 (en) 1992-10-06
NO921086D0 (en) 1992-03-19
CS92092A3 (en) 1992-12-16
JPH05148261A (en) 1993-06-15
NZ242205A (en) 1993-04-28
CN1065462A (en) 1992-10-21
HUT60748A (en) 1992-10-28
EP0507188A1 (en) 1992-10-07
FI921456A (en) 1992-10-06
HU9201117D0 (en) 1992-06-29
NO921086L (en) 1992-10-06
AU640860B2 (en) 1993-09-02
IL101482A0 (en) 1992-12-30
DE4110977A1 (en) 1992-10-08
IE921083A1 (en) 1992-10-07

Similar Documents

Publication Publication Date Title
FI916165A0 (en) 1,3-OXATIOLANNUKLEOSIDANALOGER.
FI923947A0 (en) FOERFARANDE FOER PULSBREDDSMODULATION FOER OEKAD LINEARITET, MINSKAD KOMMUTATIONSFOERLUST OCH OEKAD UTSPAENNING I EN VAEXELRIKTARE / OMRIKTARE.
FI914487A0 (en) 1,3-BENZOZAZINDERIVAT, DERAS FRAMSTAELLNING OCH ANVAENDNING.
FI913775A0 (en) I 17-STAELLNING SUBSTITUERADE KORIKOID-17-ALKYLKARBONATER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE CEILES.
FI922504A0 (en) LINEAERT VISKOELASTISK OCH VATTEN- HALTIG OCH VAETSKEFORMIG TVAETTMEDELSKOMPOSITION, AVSEDD FOER AUTOMATISKA DISKMASKINER OCH HAVANDE FOERBAETTRAD FLUORSTABILITET.
FI901201A0 (en) ANTIBAKTERIELLA 5-SUBSTITUERADE 1,4-DIHYDRO-4-OXONAFTYRIDIN-3-CARBOXYLATDERIVAT OCH DERAS FRAMSTAELLNING.
FI901669A (en) FOERFARANDE OCH ANORDNING FOER VAERME- OCH ELPRODUKTION I EN SULFATCELLULOSAFABRIK.
FI922491A0 (en) FOERBAETTRAD, FOSFAT OCH ENZYMER INNEHAOLLANDE, PULVERFORMIG DISKMEDELSKOMPOSITION FOER AUTOMATISKA DISKMASKINER.
FI922390A0 (en) INITIATORSUSPENSIONER, DERAS FRAMSTAELLNING OCH ANVAENDNING.
FI902771A0 (en) FOERFARANDE FOER FRAMSTAELLNING AV ANTIINFLAMMATORISKA 1,3,4-TIADIAZOLER OCH 1,3,4-OXADIAZOLER.
FI922492A0 (en) FOSFAT OCH ENZYMER INNEHAOLLANDE, PULVERFORMIG DISKMEDELSKOMPOSITION FOER AUTOMATISKA DISKMASKINER.
FI922377A0 (en) GLASBLANDNING, DAERAV FRAMSTAELLDA GLASFIBRER OCH DERAS FRAMSTAELLNINGSFOERFARANDE.
FI923266A0 (en) FAESTPROFIL FOER RAMAR FOER VAEGGELEMENT, DOERRAR OCH FOENSTRAR.
FI920400A0 (en) 2,5-DIARYL-1,3,4-OXADIAZOLE-HYDROXIESTER, -HYDROXIESTER, -HYDROXISYRA OCH -ACETOXIESTER OCH DERAS SYNTESMETOD.
FI921456A0 (en) SUBSTITUTES 2 ', 3'-DIDESOXY-5-TRIFLUORMETHYLURIDINE FOERFARANDEN FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING I LAEKEMEDEL.
FI924053A0 (en) SUBSTITUTE AMINOPROPANER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING.
FI921553A0 (en) BITUMENFRI BLANDNING, BYGGNADS- MATERIALBLANDNING OCH VATTENEMULSION.
FI914549A0 (en) FOERFARANDE OCH ANORDNING FOER KAPNING AV PAPPER, I SYNNERHET FOERPERFORERAT PAPPER.
FI925111A0 (en) SUBSTITUTE 1,5-PENTADIOLER OCH FOERFARANDE FOER DERAS FRAMSTAELLNING
FI924756A0 (en) 1,5-BENZOTIAZEPINONDERIVAT, DERAS FRAMSTAELLNING OCH PHARMACEUTISKA ANVAENDNING
FI925639A0 (en) ISOXAZOLYLIMIDAZOLDERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING I LAEKEMEDEL
FI923161A0 (en) OPTISKT AKTIVA ISOINDOLINDERIVAT, DERAS FRAMSTAELLNING OCH ANVAENDNING.
FI915566A (en) B-HYDROXIETYLAMINER, VILKA INNEHAOLLER EN 1,1-DISUBSTITUERAD CYKLOPROPYLREST, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING.
FI900242A0 (en) DILATATIONSFOGSKONSTRUKTION I ELDFASTA OCH ISOLERANDE BEKLAEDNADER.
FI915831A (en) SUBSTITUTE DIBENZOXATIOSINONER, -12-OXIDER OCH -12,12-DIOXIDER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING I LAEKEMEDEL.

Legal Events

Date Code Title Description
FD Application lapsed