IL101482A0 - Substituted 2',3'-dideoxy-5-trifluoromethyluridines,and pharmaceutical compositions containing them - Google Patents
Substituted 2',3'-dideoxy-5-trifluoromethyluridines,and pharmaceutical compositions containing themInfo
- Publication number
- IL101482A0 IL101482A0 IL101482A IL10148292A IL101482A0 IL 101482 A0 IL101482 A0 IL 101482A0 IL 101482 A IL101482 A IL 101482A IL 10148292 A IL10148292 A IL 10148292A IL 101482 A0 IL101482 A0 IL 101482A0
- Authority
- IL
- Israel
- Prior art keywords
- trifluoromethyluridines
- dideoxy
- substituted
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4110977A DE4110977A1 (en) | 1991-04-05 | 1991-04-05 | SUBSTITUTED 2 ', 3'-DIDESOXY-5-TRIFLUOROMETHYLURIDINES, METHOD OF THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL101482A0 true IL101482A0 (en) | 1992-12-30 |
Family
ID=6428857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL101482A IL101482A0 (en) | 1991-04-05 | 1992-04-03 | Substituted 2',3'-dideoxy-5-trifluoromethyluridines,and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0507188A1 (en) |
| JP (1) | JPH05148261A (en) |
| KR (1) | KR920019813A (en) |
| CN (1) | CN1065462A (en) |
| AU (1) | AU640860B2 (en) |
| CA (1) | CA2064916A1 (en) |
| CS (1) | CS92092A3 (en) |
| DE (1) | DE4110977A1 (en) |
| FI (1) | FI921456A (en) |
| HU (1) | HUT60748A (en) |
| IE (1) | IE921083A1 (en) |
| IL (1) | IL101482A0 (en) |
| NO (1) | NO921086L (en) |
| NZ (1) | NZ242205A (en) |
| TW (1) | TW205043B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050846C (en) * | 1995-08-03 | 2000-03-29 | 中国医学科学院医药生物技术研究所 | Antitumor antibiotic-Yunnan-mycin |
| WO2002094844A2 (en) | 2001-05-18 | 2002-11-28 | Rakesh Kumar | Antiviral nucleosides |
| CN100334100C (en) * | 2004-01-17 | 2007-08-29 | 杭州富邦生物制药有限公司 | Method for synthesizing 5-trifluoro methyl-2'-desugarized uridine |
| JP4603274B2 (en) * | 2004-02-24 | 2010-12-22 | 三井化学株式会社 | Process for producing 2'-deoxy-5-trifluoromethyluridine |
| WO2009119785A1 (en) * | 2008-03-28 | 2009-10-01 | 浜理薬品工業株式会社 | Method for purifying ethynylthymidine compound |
| US8445669B2 (en) | 2008-04-10 | 2013-05-21 | Hamari Chemicals, Ltd. | Production process of ethynylthymidine compounds from 5-methyluridine as a starting material |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3048877A1 (en) * | 1980-12-23 | 1982-07-08 | Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri | Pyrimidine nucleoside phosphonate derivs. - useful as antiviral agents |
| JPH07116042B2 (en) * | 1985-05-15 | 1995-12-13 | ザ ウエルカム フアウンデ−シヨン リミテツド | Nucleoside compound |
| GB2181128A (en) * | 1985-09-17 | 1987-04-15 | Wellcome Found | 3'-azidonucleosides |
| CA1327000C (en) * | 1987-08-07 | 1994-02-15 | David L.J. Tyrrell | Antiviral therapy for hepatitis b |
| SE8704298D0 (en) * | 1987-11-03 | 1987-11-03 | Astra Ab | COMPOUNDS FOR USE IN THERAPY |
| US4900828A (en) * | 1988-05-12 | 1990-02-13 | Hoffmann-Laroche Inc. | Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine |
| SE8802173D0 (en) * | 1988-06-10 | 1988-06-10 | Astra Ab | PYRIMIDINE DERIVATIVES |
| GB8823320D0 (en) * | 1988-10-05 | 1988-11-09 | Nycomed As | Chemical compounds |
| JPH04501854A (en) * | 1989-05-15 | 1992-04-02 | アメリカ合衆国 | How to treat hepatitis |
| NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
-
1991
- 1991-04-05 DE DE4110977A patent/DE4110977A1/en not_active Withdrawn
-
1992
- 1992-03-06 TW TW081101706A patent/TW205043B/zh active
- 1992-03-10 AU AU12190/92A patent/AU640860B2/en not_active Ceased
- 1992-03-19 NO NO92921086A patent/NO921086L/en unknown
- 1992-03-24 EP EP92105039A patent/EP0507188A1/en not_active Withdrawn
- 1992-03-26 CS CS92920A patent/CS92092A3/en unknown
- 1992-04-02 FI FI921456A patent/FI921456A/en not_active Application Discontinuation
- 1992-04-02 HU HU9201117A patent/HUT60748A/en unknown
- 1992-04-02 CA CA002064916A patent/CA2064916A1/en not_active Abandoned
- 1992-04-02 NZ NZ242205A patent/NZ242205A/en unknown
- 1992-04-03 IE IE108392A patent/IE921083A1/en unknown
- 1992-04-03 IL IL101482A patent/IL101482A0/en unknown
- 1992-04-03 JP JP4112074A patent/JPH05148261A/en active Pending
- 1992-04-04 CN CN92102448A patent/CN1065462A/en active Pending
- 1992-04-04 KR KR1019920005650A patent/KR920019813A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2064916A1 (en) | 1992-10-06 |
| AU1219092A (en) | 1992-10-08 |
| TW205043B (en) | 1993-05-01 |
| HU9201117D0 (en) | 1992-06-29 |
| CS92092A3 (en) | 1992-12-16 |
| AU640860B2 (en) | 1993-09-02 |
| EP0507188A1 (en) | 1992-10-07 |
| NZ242205A (en) | 1993-04-28 |
| DE4110977A1 (en) | 1992-10-08 |
| KR920019813A (en) | 1992-11-20 |
| HUT60748A (en) | 1992-10-28 |
| NO921086D0 (en) | 1992-03-19 |
| CN1065462A (en) | 1992-10-21 |
| FI921456A (en) | 1992-10-06 |
| NO921086L (en) | 1992-10-06 |
| FI921456A0 (en) | 1992-04-02 |
| IE921083A1 (en) | 1992-10-07 |
| JPH05148261A (en) | 1993-06-15 |
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