CS92092A3 - Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments - Google Patents

Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments

Info

Publication number
CS92092A3
CS92092A3 CS92920A CS92092A CS92092A3 CS 92092 A3 CS92092 A3 CS 92092A3 CS 92920 A CS92920 A CS 92920A CS 92092 A CS92092 A CS 92092A CS 92092 A3 CS92092 A3 CS 92092A3
Authority
CS
Czechoslovakia
Prior art keywords
uridines
dideoxy
medicaments
trifluoromethyl
substituted
Prior art date
Application number
CS92920A
Other languages
English (en)
Inventor
Dieter Dr Habich
Rainer Dr Neumann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CS92092A3 publication Critical patent/CS92092A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CS92920A 1991-04-05 1992-03-26 Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments CS92092A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4110977A DE4110977A1 (de) 1991-04-05 1991-04-05 Substituierte 2',3'-didesoxy-5-trifluormethyluridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
CS92092A3 true CS92092A3 (en) 1992-12-16

Family

ID=6428857

Family Applications (1)

Application Number Title Priority Date Filing Date
CS92920A CS92092A3 (en) 1991-04-05 1992-03-26 Substituted 2',3'-dideoxy-5-trifluoromethyl uridines, process forpreparing thereof and their use in medicaments

Country Status (15)

Country Link
EP (1) EP0507188A1 (cs)
JP (1) JPH05148261A (cs)
KR (1) KR920019813A (cs)
CN (1) CN1065462A (cs)
AU (1) AU640860B2 (cs)
CA (1) CA2064916A1 (cs)
CS (1) CS92092A3 (cs)
DE (1) DE4110977A1 (cs)
FI (1) FI921456A (cs)
HU (1) HUT60748A (cs)
IE (1) IE921083A1 (cs)
IL (1) IL101482A0 (cs)
NO (1) NO921086L (cs)
NZ (1) NZ242205A (cs)
TW (1) TW205043B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050846C (zh) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 一种抗肿瘤抗生素云南霉素及其制备方法
EP2322534A1 (en) 2001-05-18 2011-05-18 Rakesh Kumar Antiviral nucleosides
CN100334100C (zh) * 2004-01-17 2007-08-29 杭州富邦生物制药有限公司 5－三氟甲基－2’－脱氧尿苷的合成方法
JP4603274B2 (ja) * 2004-02-24 2010-12-22 三井化学株式会社 ２’−デオキシ−５−トリフルオロメチルウリジンの製造方法
JP5485138B2 (ja) * 2008-03-28 2014-05-07 浜理薬品工業株式会社 エチニルチミジン化合物の精製方法
EP2277878B1 (en) * 2008-04-10 2014-09-17 Hamari Chemicals, Ltd. Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048877A1 (de) * 1980-12-23 1982-07-08 Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri Pyrimidinnucleosid-phosphonate, verfahren zur herstellung und sie enthaltende mittel
DK224286A (da) * 1985-05-15 1986-11-16 Wellcome Found 2',3'-dideoxy-nucleosider
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
CA1327000C (en) * 1987-08-07 1994-02-15 David L.J. Tyrrell Antiviral therapy for hepatitis b
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
SE8802173D0 (sv) * 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
WO1990014079A1 (en) * 1989-05-15 1990-11-29 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method of treatment of hepatitis
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides

Also Published As

Publication number Publication date
AU640860B2 (en) 1993-09-02
IL101482A0 (en) 1992-12-30
NO921086L (no) 1992-10-06
EP0507188A1 (de) 1992-10-07
KR920019813A (ko) 1992-11-20
NZ242205A (en) 1993-04-28
NO921086D0 (no) 1992-03-19
HU9201117D0 (en) 1992-06-29
CA2064916A1 (en) 1992-10-06
IE921083A1 (en) 1992-10-07
HUT60748A (en) 1992-10-28
FI921456A0 (fi) 1992-04-02
JPH05148261A (ja) 1993-06-15
AU1219092A (en) 1992-10-08
FI921456A (fi) 1992-10-06
CN1065462A (zh) 1992-10-21
TW205043B (cs) 1993-05-01
DE4110977A1 (de) 1992-10-08

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