NO894539D0 - Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater. - Google Patents

Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater.

Info

Publication number
NO894539D0
NO894539D0 NO894539A NO894539A NO894539D0 NO 894539 D0 NO894539 D0 NO 894539D0 NO 894539 A NO894539 A NO 894539A NO 894539 A NO894539 A NO 894539A NO 894539 D0 NO894539 D0 NO 894539D0
Authority
NO
Norway
Prior art keywords
uriden
halomethylidene
guanosin
ethynylcytidine
ethenylidene
Prior art date
Application number
NO894539A
Other languages
English (en)
Other versions
NO172240B (no
NO894539L (no
NO172240C (no
Inventor
James Ray Mccarthy
Michael Louis Edwards
Donald Paul Matthews
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO894539D0 publication Critical patent/NO894539D0/no
Publication of NO894539L publication Critical patent/NO894539L/no
Publication of NO172240B publication Critical patent/NO172240B/no
Publication of NO172240C publication Critical patent/NO172240C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
NO894539A 1988-11-15 1989-11-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater NO172240C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27147988A 1988-11-15 1988-11-15

Publications (4)

Publication Number Publication Date
NO894539D0 true NO894539D0 (no) 1989-11-14
NO894539L NO894539L (no) 1990-05-16
NO172240B NO172240B (no) 1993-03-15
NO172240C NO172240C (no) 1993-06-23

Family

ID=23035764

Family Applications (1)

Application Number Title Priority Date Filing Date
NO894539A NO172240C (no) 1988-11-15 1989-11-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater

Country Status (19)

Country Link
EP (1) EP0372268B1 (no)
JP (1) JP2802947B2 (no)
KR (1) KR0144865B1 (no)
CN (1) CN1022248C (no)
AR (1) AR247891A1 (no)
AT (1) ATE105297T1 (no)
AU (1) AU621160B2 (no)
CA (1) CA2002648C (no)
DE (1) DE68915128T2 (no)
DK (1) DK171844B1 (no)
ES (1) ES2056180T3 (no)
FI (1) FI92588C (no)
HU (3) HU205134B (no)
IE (1) IE63563B1 (no)
IL (1) IL92293A (no)
NO (1) NO172240C (no)
NZ (1) NZ231365A (no)
PT (1) PT92309B (no)
ZA (1) ZA898567B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (en) * 1992-04-23 1993-11-11 Yoshitomi Pharmaceutical Industries, Ltd. 2'-methylidenenucleoside compound and pharmaceutical use thereof
KR100255258B1 (ko) * 1992-05-12 2000-05-01 슈테펜 엘. 네스비트 리보뉴클레오티드 환원 효소 억제제의 제조방법
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
NZ258015A (en) * 1992-12-03 1997-01-29 Merrell Dow Pharma Use of acyclovir-like compounds in conjunction with 2'-(halo)methylidene nucleoside analogues in anti-viral treatment
DE69421721T2 (de) * 1994-01-07 2000-04-27 Merrell Pharma Inc (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydrat
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
WO1996001638A1 (en) * 1994-07-11 1996-01-25 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
KR20040094692A (ko) * 2002-02-14 2004-11-10 파마셋, 리미티드 변형된 불소화 뉴클레오사이드 유사체
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) * 2004-10-27 2008-05-21 北京东华康明生物科技有限公司 （反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
HUE041509T2 (hu) 2011-12-22 2019-05-28 Janssen Biopharma Inc Szubsztituált nukleozidok, nukleotidok és ezek analógjai
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CA2891125A1 (en) * 2012-11-19 2014-05-22 Merck Sharp & Dohme Corp. 2 -alkynyl substituted nucleoside derivatives for treating viral diseases
WO2018092107A1 (en) * 2016-11-21 2018-05-24 Munisekhar Medasani Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도

Also Published As

Publication number Publication date
PT92309A (pt) 1990-05-31
HU00045A9 (en) 1995-01-30
IL92293A (en) 1995-01-24
HUT51642A (en) 1990-05-28
DK570089A (da) 1990-05-16
NZ231365A (en) 1992-08-26
IE893651L (en) 1990-05-15
ATE105297T1 (de) 1994-05-15
KR900007833A (ko) 1990-06-02
DK171844B1 (da) 1997-06-30
DK570089D0 (da) 1989-11-14
JP2802947B2 (ja) 1998-09-24
HU895900D0 (en) 1990-02-28
CA2002648C (en) 2000-02-29
AU4461189A (en) 1990-05-24
IL92293A0 (en) 1990-07-26
DE68915128D1 (de) 1994-06-09
CN1042715A (zh) 1990-06-06
JPH02178272A (ja) 1990-07-11
HU210343A9 (en) 1995-03-28
KR0144865B1 (ko) 1998-07-01
AR247891A1 (es) 1995-04-28
IE63563B1 (en) 1995-05-17
CA2002648A1 (en) 1990-05-15
FI92588C (fi) 1994-12-12
FI92588B (fi) 1994-08-31
ES2056180T3 (es) 1994-10-01
NO172240B (no) 1993-03-15
NO894539L (no) 1990-05-16
AU621160B2 (en) 1992-03-05
EP0372268B1 (en) 1994-05-04
EP0372268A1 (en) 1990-06-13
CN1022248C (zh) 1993-09-29
HU205134B (en) 1992-03-30
FI895417A0 (fi) 1989-11-14
NO172240C (no) 1993-06-23
ZA898567B (en) 1990-08-29
DE68915128T2 (de) 1994-08-25
PT92309B (pt) 1996-06-28

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