DE68915128T2 - Derivate von 2'-Halomethyliden, 2'-Ethenyliden und 2'-Ethynylcytidin, Uridin und Guanosin. - Google Patents
Derivate von 2'-Halomethyliden, 2'-Ethenyliden und 2'-Ethynylcytidin, Uridin und Guanosin.Info
- Publication number
- DE68915128T2 DE68915128T2 DE68915128T DE68915128T DE68915128T2 DE 68915128 T2 DE68915128 T2 DE 68915128T2 DE 68915128 T DE68915128 T DE 68915128T DE 68915128 T DE68915128 T DE 68915128T DE 68915128 T2 DE68915128 T2 DE 68915128T2
- Authority
- DE
- Germany
- Prior art keywords
- halomethylidene
- ethynylcytidine
- ethenylidene
- uridine
- guanosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27147988A | 1988-11-15 | 1988-11-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68915128D1 DE68915128D1 (de) | 1994-06-09 |
DE68915128T2 true DE68915128T2 (de) | 1994-08-25 |
Family
ID=23035764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68915128T Expired - Fee Related DE68915128T2 (de) | 1988-11-15 | 1989-11-15 | Derivate von 2'-Halomethyliden, 2'-Ethenyliden und 2'-Ethynylcytidin, Uridin und Guanosin. |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0372268B1 (de) |
JP (1) | JP2802947B2 (de) |
KR (1) | KR0144865B1 (de) |
CN (1) | CN1022248C (de) |
AR (1) | AR247891A1 (de) |
AT (1) | ATE105297T1 (de) |
AU (1) | AU621160B2 (de) |
CA (1) | CA2002648C (de) |
DE (1) | DE68915128T2 (de) |
DK (1) | DK171844B1 (de) |
ES (1) | ES2056180T3 (de) |
FI (1) | FI92588C (de) |
HU (3) | HU205134B (de) |
IE (1) | IE63563B1 (de) |
IL (1) | IL92293A (de) |
NO (1) | NO172240C (de) |
NZ (1) | NZ231365A (de) |
PT (1) | PT92309B (de) |
ZA (1) | ZA898567B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458772B1 (en) | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
US5047520A (en) * | 1987-03-19 | 1991-09-10 | Yamasa Shoyu Kabushiki Kaisha | 2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof |
NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
US5521163A (en) * | 1990-07-13 | 1996-05-28 | University Of Birmingham | Antiviral pyrimidine nucleosides and methods for using same |
FR2668153B1 (fr) * | 1990-10-22 | 1995-03-31 | Pasteur Merieux Serums Vacc | Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant. |
WO1993022327A1 (en) * | 1992-04-23 | 1993-11-11 | Yoshitomi Pharmaceutical Industries, Ltd. | 2'-methylidenenucleoside compound and pharmaceutical use thereof |
ES2098032T3 (es) * | 1992-05-12 | 1997-04-16 | Merrell Pharma Inc | Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa. |
US5589587A (en) * | 1992-05-12 | 1996-12-31 | Merrell Pharmaceuticals Inc. | Process for the preparation of ribonucleotide reductase inhibitors |
EP0671918B1 (de) * | 1992-12-03 | 1997-05-28 | Merrell Pharmaceuticals Inc. | Zubereitungen, die acyclovir-ähnliche verbindungen und 2'-vinylsubstituierte nukleosidanaloge enthalten, zur behandlung viraler infektionen |
DK0738273T3 (da) * | 1994-01-07 | 2000-04-17 | Merrell Pharma Inc | Monohydrat af (E) - 2' - (fluormethylen) -- cytidin |
US5627053A (en) * | 1994-03-29 | 1997-05-06 | Ribozyme Pharmaceuticals, Inc. | 2'deoxy-2'-alkylnucleotide containing nucleic acid |
AU2768295A (en) * | 1994-07-11 | 1996-02-09 | Hoechst Marion Roussel, Inc. | Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy |
WO1996001834A1 (fr) * | 1994-07-12 | 1996-01-25 | Yamasa Corporation | 2'-desoxy-2'-(methylidene substitue ou non substitue)-4'-thionucleoside |
EP1438054A4 (de) * | 2001-09-28 | 2006-07-26 | Idenix Cayman Ltd | Verfahren und zusammensetzungen zur behandlung von flaviviren und pestiviren mit 4'-modifiziertem nucleosid |
CA2476279A1 (en) * | 2002-02-14 | 2003-08-21 | Lieven J. Stuyver | Modified fluorinated nucleoside analogues |
KR20040036417A (ko) * | 2002-10-25 | 2004-04-30 | 정낙신 | 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물 |
CN100389119C (zh) * | 2004-10-27 | 2008-05-21 | 北京东华康明生物科技有限公司 | (反式)-2-脱氧-2-(氟亚甲基)-4-r酰胞苷化合物及其制备方法 |
BR112014014740B1 (pt) | 2011-12-22 | 2021-08-24 | Alios Biopharma, Inc | Compostos de nucleosídeos, nucleotídeos e análogos destes, seu uso e composição farmacêutica |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
KR20150086325A (ko) * | 2012-11-19 | 2015-07-27 | 머크 샤프 앤드 돔 코포레이션 | 바이러스성 질환을 치료하기 위한 2''-알키닐 치환된 뉴클레오시드 유도체 |
WO2018092107A1 (en) * | 2016-11-21 | 2018-05-24 | Munisekhar Medasani | Novel anti-viral and anti-cancer molecule |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047520A (en) * | 1987-03-19 | 1991-09-10 | Yamasa Shoyu Kabushiki Kaisha | 2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof |
-
1989
- 1989-11-09 ZA ZA898567A patent/ZA898567B/xx unknown
- 1989-11-09 CA CA002002648A patent/CA2002648C/en not_active Expired - Lifetime
- 1989-11-10 AR AR89315416A patent/AR247891A1/es active
- 1989-11-10 AU AU44611/89A patent/AU621160B2/en not_active Ceased
- 1989-11-13 NZ NZ231365A patent/NZ231365A/en unknown
- 1989-11-13 IL IL9229389A patent/IL92293A/en not_active IP Right Cessation
- 1989-11-14 PT PT92309A patent/PT92309B/pt not_active IP Right Cessation
- 1989-11-14 KR KR1019890016636A patent/KR0144865B1/ko not_active IP Right Cessation
- 1989-11-14 IE IE365189A patent/IE63563B1/en not_active IP Right Cessation
- 1989-11-14 HU HU895900A patent/HU205134B/hu not_active IP Right Cessation
- 1989-11-14 DK DK570089A patent/DK171844B1/da not_active IP Right Cessation
- 1989-11-14 NO NO894539A patent/NO172240C/no not_active IP Right Cessation
- 1989-11-14 FI FI895417A patent/FI92588C/fi not_active IP Right Cessation
- 1989-11-15 CN CN89108557A patent/CN1022248C/zh not_active Expired - Fee Related
- 1989-11-15 JP JP1297225A patent/JP2802947B2/ja not_active Expired - Fee Related
- 1989-11-15 ES ES89121139T patent/ES2056180T3/es not_active Expired - Lifetime
- 1989-11-15 EP EP89121139A patent/EP0372268B1/de not_active Expired - Lifetime
- 1989-11-15 AT AT8989121139T patent/ATE105297T1/de not_active IP Right Cessation
- 1989-11-15 DE DE68915128T patent/DE68915128T2/de not_active Expired - Fee Related
-
1994
- 1994-11-14 HU HU94P/P00045P patent/HU00045A9/hu unknown
- 1994-11-14 HU HU94P/P00045P patent/HU210343A9/hu unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MERRELL PHARMACEUTICALS INC. (N.D.GES.D. STAATES D |
|
8339 | Ceased/non-payment of the annual fee |