DK171844B1 - 2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid - Google Patents

2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid Download PDF

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Publication number
DK171844B1
DK171844B1 DK570089A DK570089A DK171844B1 DK 171844 B1 DK171844 B1 DK 171844B1 DK 570089 A DK570089 A DK 570089A DK 570089 A DK570089 A DK 570089A DK 171844 B1 DK171844 B1 DK 171844B1
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DK
Denmark
Prior art keywords
alkoxy
methylidene
halogen
diyl
cytidine
Prior art date
Application number
DK570089A
Other languages
Danish (da)
English (en)
Other versions
DK570089A (da
DK570089D0 (da
Inventor
James Ray Mccarthy
Michael Louis Edwards
Donald Paul Matthews
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK570089D0 publication Critical patent/DK570089D0/da
Publication of DK570089A publication Critical patent/DK570089A/da
Application granted granted Critical
Publication of DK171844B1 publication Critical patent/DK171844B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
DK570089A 1988-11-15 1989-11-14 2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid DK171844B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27147988A 1988-11-15 1988-11-15
US27147988 1988-11-15

Publications (3)

Publication Number Publication Date
DK570089D0 DK570089D0 (da) 1989-11-14
DK570089A DK570089A (da) 1990-05-16
DK171844B1 true DK171844B1 (da) 1997-06-30

Family

ID=23035764

Family Applications (1)

Application Number Title Priority Date Filing Date
DK570089A DK171844B1 (da) 1988-11-15 1989-11-14 2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid

Country Status (19)

Country Link
EP (1) EP0372268B1 (de)
JP (1) JP2802947B2 (de)
KR (1) KR0144865B1 (de)
CN (1) CN1022248C (de)
AR (1) AR247891A1 (de)
AT (1) ATE105297T1 (de)
AU (1) AU621160B2 (de)
CA (1) CA2002648C (de)
DE (1) DE68915128T2 (de)
DK (1) DK171844B1 (de)
ES (1) ES2056180T3 (de)
FI (1) FI92588C (de)
HU (3) HU205134B (de)
IE (1) IE63563B1 (de)
IL (1) IL92293A (de)
NO (1) NO172240C (de)
NZ (1) NZ231365A (de)
PT (1) PT92309B (de)
ZA (1) ZA898567B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
EP0310673B1 (de) * 1987-03-19 1995-07-05 Yamasa Shoyu Kabushiki Kaisha 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (en) * 1992-04-23 1993-11-11 Yoshitomi Pharmaceutical Industries, Ltd. 2'-methylidenenucleoside compound and pharmaceutical use thereof
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
ES2098032T3 (es) * 1992-05-12 1997-04-16 Merrell Pharma Inc Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa.
JPH08503942A (ja) * 1992-12-03 1996-04-30 メレルダウファーマスーティカルズ インコーポレイテッド アシクロビル様化合物類と２’−ビニル置換ヌクレオシド類似体との連係療法によるウイルス感染の処置法
CA2179987C (en) * 1994-01-07 1999-01-19 Richard E. Donaldson Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
WO1996001638A1 (en) * 1994-07-11 1996-01-25 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO1996001834A1 (fr) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-desoxy-2'-(methylidene substitue ou non substitue)-4'-thionucleoside
WO2003026675A1 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
CN1646534A (zh) * 2002-02-14 2005-07-27 法玛塞特有限公司 修饰的氟化核苷类似物
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) * 2004-10-27 2008-05-21 北京东华康明生物科技有限公司 （反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
EP2794627B1 (de) 2011-12-22 2018-09-26 Alios Biopharma, Inc. Substituierte nukleoside, nukleotide und analoga davon
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
KR20150086325A (ko) * 2012-11-19 2015-07-27 머크 샤프 앤드 돔 코포레이션 바이러스성 질환을 치료하기 위한 2''-알키닐 치환된 뉴클레오시드 유도체
WO2018092107A1 (en) * 2016-11-21 2018-05-24 Munisekhar Medasani Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310673B1 (de) * 1987-03-19 1995-07-05 Yamasa Shoyu Kabushiki Kaisha 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung

Also Published As

Publication number Publication date
EP0372268A1 (de) 1990-06-13
EP0372268B1 (de) 1994-05-04
PT92309A (pt) 1990-05-31
NO894539D0 (no) 1989-11-14
DE68915128D1 (de) 1994-06-09
DK570089A (da) 1990-05-16
NO894539L (no) 1990-05-16
HU205134B (en) 1992-03-30
PT92309B (pt) 1996-06-28
AU4461189A (en) 1990-05-24
DE68915128T2 (de) 1994-08-25
KR900007833A (ko) 1990-06-02
HU210343A9 (en) 1995-03-28
ES2056180T3 (es) 1994-10-01
ZA898567B (en) 1990-08-29
FI92588B (fi) 1994-08-31
AU621160B2 (en) 1992-03-05
IE63563B1 (en) 1995-05-17
ATE105297T1 (de) 1994-05-15
CA2002648C (en) 2000-02-29
FI92588C (fi) 1994-12-12
CN1022248C (zh) 1993-09-29
JPH02178272A (ja) 1990-07-11
AR247891A1 (es) 1995-04-28
IL92293A0 (en) 1990-07-26
IL92293A (en) 1995-01-24
NO172240C (no) 1993-06-23
NO172240B (no) 1993-03-15
HU00045A9 (en) 1995-01-30
KR0144865B1 (ko) 1998-07-01
DK570089D0 (da) 1989-11-14
FI895417A0 (fi) 1989-11-14
IE893651L (en) 1990-05-15
HU895900D0 (en) 1990-02-28
NZ231365A (en) 1992-08-26
CA2002648A1 (en) 1990-05-15
JP2802947B2 (ja) 1998-09-24
CN1042715A (zh) 1990-06-06
HUT51642A (en) 1990-05-28

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B1 Patent granted (law 1993)
PBP Patent lapsed

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