DK570089A - 2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-cytidin-, -uridin- og -guanosin-derivater, deres fremstilling og anvendelse - Google Patents

2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-cytidin-, -uridin- og -guanosin-derivater, deres fremstilling og anvendelse

Info

Publication number
DK570089A
DK570089A DK570089A DK570089A DK570089A DK 570089 A DK570089 A DK 570089A DK 570089 A DK570089 A DK 570089A DK 570089 A DK570089 A DK 570089A DK 570089 A DK570089 A DK 570089A
Authority
DK
Denmark
Prior art keywords
halogenmethylidene
ethenylidene
cytidine
uridine
ethynyl
Prior art date
Application number
DK570089A
Other languages
English (en)
Other versions
DK171844B1 (da
DK570089D0 (da
Inventor
James Ray Mccarthy
Michael Louis Edwards
Donald Paul Matthews
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK570089D0 publication Critical patent/DK570089D0/da
Publication of DK570089A publication Critical patent/DK570089A/da
Application granted granted Critical
Publication of DK171844B1 publication Critical patent/DK171844B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DK570089A 1988-11-15 1989-11-14 2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid DK171844B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27147988A 1988-11-15 1988-11-15
US27147988 1988-11-15

Publications (3)

Publication Number Publication Date
DK570089D0 DK570089D0 (da) 1989-11-14
DK570089A true DK570089A (da) 1990-05-16
DK171844B1 DK171844B1 (da) 1997-06-30

Family

ID=23035764

Family Applications (1)

Application Number Title Priority Date Filing Date
DK570089A DK171844B1 (da) 1988-11-15 1989-11-14 2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid

Country Status (19)

Country Link
EP (1) EP0372268B1 (da)
JP (1) JP2802947B2 (da)
KR (1) KR0144865B1 (da)
CN (1) CN1022248C (da)
AR (1) AR247891A1 (da)
AT (1) ATE105297T1 (da)
AU (1) AU621160B2 (da)
CA (1) CA2002648C (da)
DE (1) DE68915128T2 (da)
DK (1) DK171844B1 (da)
ES (1) ES2056180T3 (da)
FI (1) FI92588C (da)
HU (3) HU205134B (da)
IE (1) IE63563B1 (da)
IL (1) IL92293A (da)
NO (1) NO172240C (da)
NZ (1) NZ231365A (da)
PT (1) PT92309B (da)
ZA (1) ZA898567B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (en) * 1992-04-23 1993-11-11 Yoshitomi Pharmaceutical Industries, Ltd. 2'-methylidenenucleoside compound and pharmaceutical use thereof
NZ251886A (en) * 1992-05-12 1996-02-27 Merrell Dow Pharma Ribonucleotide reductase inhibitors and their production
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
ATE153533T1 (de) * 1992-12-03 1997-06-15 Merrell Pharma Inc Zubereitungen, die acyclovir-ähnliche verbindungen und 2'-vinylsubstituierte nukleosidanaloge enthalten, zur behandlung viraler infektionen
NZ279030A (en) * 1994-01-07 1997-05-26 Merrell Pharma Inc 2'-deoxy-2'-(fluoromethylene)cytidine
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
WO1996001638A1 (en) * 1994-07-11 1996-01-25 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO1996001834A1 (fr) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-desoxy-2'-(methylidene substitue ou non substitue)-4'-thionucleoside
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
KR20040094692A (ko) * 2002-02-14 2004-11-10 파마셋, 리미티드 변형된 불소화 뉴클레오사이드 유사체
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) * 2004-10-27 2008-05-21 北京东华康明生物科技有限公司 （反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
SG11201402826YA (en) 2011-12-22 2014-12-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
MX2015006248A (es) * 2012-11-19 2015-08-14 Merck Sharp & Dohme Derivados de nucleosido 2'-alquinilo sustituido para el tratamiento de enfermedades virales.
WO2018092107A1 (en) * 2016-11-21 2018-05-24 Munisekhar Medasani Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도

Also Published As

Publication number Publication date
DK171844B1 (da) 1997-06-30
HU210343A9 (en) 1995-03-28
NO172240C (no) 1993-06-23
NZ231365A (en) 1992-08-26
JPH02178272A (ja) 1990-07-11
NO172240B (no) 1993-03-15
DE68915128T2 (de) 1994-08-25
IE63563B1 (en) 1995-05-17
CN1042715A (zh) 1990-06-06
AR247891A1 (es) 1995-04-28
PT92309A (pt) 1990-05-31
FI92588C (fi) 1994-12-12
FI92588B (fi) 1994-08-31
JP2802947B2 (ja) 1998-09-24
CA2002648A1 (en) 1990-05-15
ES2056180T3 (es) 1994-10-01
PT92309B (pt) 1996-06-28
DK570089D0 (da) 1989-11-14
EP0372268B1 (en) 1994-05-04
EP0372268A1 (en) 1990-06-13
FI895417A0 (fi) 1989-11-14
ATE105297T1 (de) 1994-05-15
HU00045A9 (en) 1995-01-30
HU205134B (en) 1992-03-30
CN1022248C (zh) 1993-09-29
IE893651L (en) 1990-05-15
IL92293A0 (en) 1990-07-26
KR0144865B1 (ko) 1998-07-01
AU621160B2 (en) 1992-03-05
IL92293A (en) 1995-01-24
CA2002648C (en) 2000-02-29
HU895900D0 (en) 1990-02-28
HUT51642A (en) 1990-05-28
AU4461189A (en) 1990-05-24
ZA898567B (en) 1990-08-29
NO894539L (no) 1990-05-16
NO894539D0 (no) 1989-11-14
KR900007833A (ko) 1990-06-02
DE68915128D1 (de) 1994-06-09

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