NO332519B1 - Inhalasjonslosningsformulering med et tiotropiumsalt, fremgangsmate for fremstilling av slike samt slike formuleringer for behandling av sykdom - Google Patents
Inhalasjonslosningsformulering med et tiotropiumsalt, fremgangsmate for fremstilling av slike samt slike formuleringer for behandling av sykdom Download PDFInfo
- Publication number
- NO332519B1 NO332519B1 NO20031911A NO20031911A NO332519B1 NO 332519 B1 NO332519 B1 NO 332519B1 NO 20031911 A NO20031911 A NO 20031911A NO 20031911 A NO20031911 A NO 20031911A NO 332519 B1 NO332519 B1 NO 332519B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutical formulation
- formulation according
- tiotropium
- water
- active substance
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 64
- 238000009472 formulation Methods 0.000 title claims abstract description 50
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title claims description 31
- 238000000034 method Methods 0.000 title description 9
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229940041682 inhalant solution Drugs 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims abstract description 28
- 229960000257 tiotropium bromide Drugs 0.000 claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 25
- MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 claims abstract description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 26
- 239000013543 active substance Substances 0.000 claims description 22
- 239000002904 solvent Substances 0.000 claims description 20
- 239000000654 additive Substances 0.000 claims description 18
- 229940110309 tiotropium Drugs 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- 229940037001 sodium edetate Drugs 0.000 claims description 10
- 239000003755 preservative agent Substances 0.000 claims description 8
- 239000008139 complexing agent Substances 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical group O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 2
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 claims description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
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- -1 hydroxydi-2-thienylacetyl Chemical group 0.000 description 8
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
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- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
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- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
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- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
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- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10054036 | 2000-10-31 | ||
| PCT/EP2001/012292 WO2002036104A2 (de) | 2000-10-31 | 2001-10-24 | Inhalative lösungsformulierung mit einem tiotropiumsalz |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20031911D0 NO20031911D0 (no) | 2003-04-29 |
| NO20031911L NO20031911L (no) | 2003-04-29 |
| NO332519B1 true NO332519B1 (no) | 2012-10-08 |
Family
ID=7661723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20031911A NO332519B1 (no) | 2000-10-31 | 2003-04-29 | Inhalasjonslosningsformulering med et tiotropiumsalt, fremgangsmate for fremstilling av slike samt slike formuleringer for behandling av sykdom |
Country Status (39)
| Country | Link |
|---|---|
| EP (2) | EP1837021A3 (uk) |
| JP (1) | JP4344135B2 (uk) |
| KR (1) | KR100853107B1 (uk) |
| CN (2) | CN100396285C (uk) |
| AR (1) | AR038764A1 (uk) |
| AT (1) | ATE373473T1 (uk) |
| AU (2) | AU2173802A (uk) |
| BG (1) | BG66315B1 (uk) |
| BR (1) | BRPI0115076B8 (uk) |
| CA (1) | CA2426074C (uk) |
| CY (1) | CY1107825T1 (uk) |
| CZ (1) | CZ300794B6 (uk) |
| DE (2) | DE10152521A1 (uk) |
| DK (1) | DK1333819T3 (uk) |
| EA (1) | EA007604B1 (uk) |
| EC (1) | ECSP034541A (uk) |
| EE (1) | EE05314B1 (uk) |
| ES (1) | ES2294045T3 (uk) |
| HK (1) | HK1060524A1 (uk) |
| HR (1) | HRP20030338B1 (uk) |
| HU (1) | HU229411B1 (uk) |
| IL (2) | IL155538A0 (uk) |
| ME (1) | ME00244B (uk) |
| MX (1) | MXPA03003742A (uk) |
| MY (1) | MY138940A (uk) |
| NO (1) | NO332519B1 (uk) |
| NZ (1) | NZ526023A (uk) |
| PE (1) | PE20030092A1 (uk) |
| PL (1) | PL203316B1 (uk) |
| PT (1) | PT1333819E (uk) |
| RS (1) | RS50859B (uk) |
| SA (1) | SA01220482B1 (uk) |
| SI (1) | SI1333819T1 (uk) |
| SK (1) | SK286027B6 (uk) |
| TW (1) | TWI293885B (uk) |
| UA (1) | UA78690C2 (uk) |
| UY (1) | UY26989A1 (uk) |
| WO (1) | WO2002036104A2 (uk) |
| ZA (1) | ZA200302922B (uk) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10216036A1 (de) * | 2002-04-11 | 2003-10-23 | Boehringer Ingelheim Pharma | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
| CN1292748C (zh) * | 2003-03-05 | 2007-01-03 | 南昌弘益科技有限公司 | 噻托溴铵吸入粉雾剂及其制备工艺 |
| AU2004285685B2 (en) * | 2003-11-03 | 2011-03-24 | Boehringer Ingelheim International Gmbh | Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same |
| AU2004285683C1 (en) * | 2003-11-03 | 2011-09-08 | Boehringer Ingelheim International Gmbh | Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same |
| BRPI0609295A2 (pt) | 2005-05-02 | 2010-03-23 | Boehringer Ingelheim Int | formas cristalinas de brometo de tiotràpio, composiÇço farmacÊutica, uso e mÉtodo para preparar as mesmas |
| EP2044967A1 (de) * | 2007-10-01 | 2009-04-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Zerstäuber |
| CN104306361A (zh) * | 2014-09-24 | 2015-01-28 | 万特制药(海南)有限公司 | 一种含噻托溴铵的吸入性溶液 |
| CN111374963A (zh) * | 2018-12-31 | 2020-07-07 | 天津药业研究院有限公司 | 一种用于吸入的噻托铵溶液剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| SG45171A1 (en) * | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| DE19536902A1 (de) * | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| DE19847968A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
-
2001
- 2001-10-24 AU AU2173802A patent/AU2173802A/xx active Pending
- 2001-10-24 DE DE10152521A patent/DE10152521A1/de not_active Withdrawn
- 2001-10-24 CZ CZ20031486A patent/CZ300794B6/cs unknown
- 2001-10-24 CA CA002426074A patent/CA2426074C/en not_active Expired - Fee Related
- 2001-10-24 EE EEP200300203A patent/EE05314B1/xx unknown
- 2001-10-24 DE DE50113037T patent/DE50113037D1/de not_active Expired - Lifetime
- 2001-10-24 AT AT01992567T patent/ATE373473T1/de active
- 2001-10-24 RS YUP-330/03A patent/RS50859B/sr unknown
- 2001-10-24 PT PT01992567T patent/PT1333819E/pt unknown
- 2001-10-24 KR KR1020037006013A patent/KR100853107B1/ko active IP Right Grant
- 2001-10-24 SK SK527-2003A patent/SK286027B6/sk not_active IP Right Cessation
- 2001-10-24 PL PL360405A patent/PL203316B1/pl unknown
- 2001-10-24 EA EA200300482A patent/EA007604B1/ru not_active IP Right Cessation
- 2001-10-24 IL IL15553801A patent/IL155538A0/xx active IP Right Grant
- 2001-10-24 ES ES01992567T patent/ES2294045T3/es not_active Expired - Lifetime
- 2001-10-24 EP EP07111499A patent/EP1837021A3/de not_active Withdrawn
- 2001-10-24 CN CNB018183158A patent/CN100396285C/zh not_active Expired - Lifetime
- 2001-10-24 ME MEP-2008-404A patent/ME00244B/me unknown
- 2001-10-24 BR BRPI0115076A patent/BRPI0115076B8/pt not_active IP Right Cessation
- 2001-10-24 AU AU2002221738A patent/AU2002221738B2/en not_active Expired
- 2001-10-24 NZ NZ526023A patent/NZ526023A/en not_active IP Right Cessation
- 2001-10-24 JP JP2002538916A patent/JP4344135B2/ja not_active Expired - Lifetime
- 2001-10-24 UA UA2003054959A patent/UA78690C2/uk unknown
- 2001-10-24 CN CNA2008100985489A patent/CN101292964A/zh active Pending
- 2001-10-24 HU HU0301378A patent/HU229411B1/hu unknown
- 2001-10-24 SI SI200130774T patent/SI1333819T1/sl unknown
- 2001-10-24 WO PCT/EP2001/012292 patent/WO2002036104A2/de active IP Right Grant
- 2001-10-24 DK DK01992567T patent/DK1333819T3/da active
- 2001-10-24 MX MXPA03003742A patent/MXPA03003742A/es active IP Right Grant
- 2001-10-24 EP EP01992567A patent/EP1333819B1/de not_active Expired - Lifetime
- 2001-10-28 SA SA01220482A patent/SA01220482B1/ar unknown
- 2001-10-29 MY MYPI20015000A patent/MY138940A/en unknown
- 2001-10-29 UY UY26989A patent/UY26989A1/es not_active Application Discontinuation
- 2001-10-29 TW TW090126764A patent/TWI293885B/zh active
- 2001-10-31 PE PE2001001086A patent/PE20030092A1/es not_active Application Discontinuation
- 2001-10-31 AR ARP010105087A patent/AR038764A1/es not_active Ceased/Invalidation/Refusal/Rejection/Nullification
-
2003
- 2003-04-07 EC EC2003004541A patent/ECSP034541A/es unknown
- 2003-04-14 ZA ZA200302922A patent/ZA200302922B/en unknown
- 2003-04-16 BG BG107727A patent/BG66315B1/bg active Active
- 2003-04-21 IL IL155538A patent/IL155538A/en unknown
- 2003-04-28 HR HR20030338A patent/HRP20030338B1/xx not_active IP Right Cessation
- 2003-04-29 NO NO20031911A patent/NO332519B1/no not_active IP Right Cessation
-
2004
- 2004-05-20 HK HK04103586A patent/HK1060524A1/xx not_active IP Right Cessation
-
2007
- 2007-12-07 CY CY20071101562T patent/CY1107825T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |