NO331882B1 - Anvendelse av IL-18 inhibitorer til a behandle eller forhindre CNS-skader - Google Patents

Anvendelse av IL-18 inhibitorer til a behandle eller forhindre CNS-skader Download PDF

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Publication number
NO331882B1
NO331882B1 NO20035160A NO20035160A NO331882B1 NO 331882 B1 NO331882 B1 NO 331882B1 NO 20035160 A NO20035160 A NO 20035160A NO 20035160 A NO20035160 A NO 20035160A NO 331882 B1 NO331882 B1 NO 331882B1
Authority
NO
Norway
Prior art keywords
use according
inhibitor
injury
brain
interferon
Prior art date
Application number
NO20035160A
Other languages
English (en)
Norwegian (no)
Other versions
NO20035160L (no
NO20035160D0 (no
Inventor
Esther Shohami
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of NO20035160L publication Critical patent/NO20035160L/no
Publication of NO20035160D0 publication Critical patent/NO20035160D0/no
Publication of NO331882B1 publication Critical patent/NO331882B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20035160A 2001-05-25 2003-11-20 Anvendelse av IL-18 inhibitorer til a behandle eller forhindre CNS-skader NO331882B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112067 2001-05-25
PCT/EP2002/005666 WO2002096456A1 (en) 2001-05-25 2002-05-23 Use of il-18 inhibitors for treating or preventing cns injuries

Publications (3)

Publication Number Publication Date
NO20035160L NO20035160L (no) 2003-11-20
NO20035160D0 NO20035160D0 (no) 2003-11-20
NO331882B1 true NO331882B1 (no) 2012-04-23

Family

ID=8177454

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20035160A NO331882B1 (no) 2001-05-25 2003-11-20 Anvendelse av IL-18 inhibitorer til a behandle eller forhindre CNS-skader

Country Status (30)

Country Link
US (1) US7655616B2 (ru)
EP (1) EP1390070B1 (ru)
JP (1) JP4344142B2 (ru)
KR (1) KR20040030625A (ru)
CN (1) CN1305529C (ru)
AU (1) AU2002314103B2 (ru)
BG (1) BG66395B1 (ru)
BR (1) BR0210007A (ru)
CA (1) CA2445664C (ru)
CY (1) CY1119190T1 (ru)
CZ (1) CZ307321B6 (ru)
DK (1) DK1390070T3 (ru)
EA (1) EA006744B1 (ru)
EE (1) EE05263B1 (ru)
ES (1) ES2617084T3 (ru)
HK (1) HK1069762A1 (ru)
HR (1) HRP20030842B1 (ru)
HU (1) HU230294B1 (ru)
IL (2) IL159014A0 (ru)
LT (1) LT1390070T (ru)
ME (1) ME00550B (ru)
MX (1) MXPA03010743A (ru)
NO (1) NO331882B1 (ru)
PL (1) PL216228B1 (ru)
PT (1) PT1390070T (ru)
RS (1) RS56006B1 (ru)
SK (1) SK288413B6 (ru)
UA (1) UA80396C2 (ru)
WO (1) WO2002096456A1 (ru)
ZA (1) ZA200308172B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5074030B2 (ja) 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Il−18結合タンパク質の活性変異体とその医学的応用
DK2177907T3 (da) * 2004-06-30 2014-03-24 Atsuo Sekiyama Indikatormiddel til ikke-inflammatorisk stressreaktion og anvendelse dertil
ATE557038T1 (de) 2005-06-03 2012-05-15 Ares Trading Sa Herstellung von rekombinantem il-18 bindendem protein
US8128920B2 (en) * 2005-06-03 2012-03-06 Merck Serono Sa Use of IL-18BP isoforms for the treatment and/or prevention of neurological inflammatory diseases
EP1891088B1 (en) 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
US8685400B2 (en) * 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
EP3041864B1 (en) * 2013-09-05 2021-07-21 AB2 Bio SA Il-18 binding protein (il-18bp) in inflammatory diseases
AU2016227644B2 (en) * 2015-03-05 2022-06-16 Ab2 Bio Sa IL-18 Binding Protein (IL-18BP) and antibodies in inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0873453A (ja) * 1994-09-02 1996-03-19 Otsuka Pharmaceut Co Ltd サイトカイン阻害剤
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
ATE296812T1 (de) * 1998-03-09 2005-06-15 Vertex Pharma 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
PT1278540E (pt) 2000-05-05 2008-07-03 Inst Nat Sante Rech Med Utilização de inibidores da il-18 para o tratamento e/ou prevenção de aterosclerose
ES2227220T3 (es) * 2000-06-23 2005-04-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem 2-arachidonylglycerol (2-ag) - inhibidor de factor de necrosis tumoral alfa y neuroprotector cerebral en traumatismo craneoencefalico cerrado.
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
US6671553B1 (en) * 2001-05-23 2003-12-30 Pacesetter, Inc. Implantable cardiac lead having terminating connector strain relief and method of manufacture

Also Published As

Publication number Publication date
EP1390070A1 (en) 2004-02-25
PL216228B1 (pl) 2014-03-31
US7655616B2 (en) 2010-02-02
IL159014A (en) 2012-05-31
EE05263B1 (et) 2010-02-15
YU89403A (sh) 2006-05-25
JP4344142B2 (ja) 2009-10-14
PL367545A1 (en) 2005-02-21
CZ20033268A3 (en) 2004-07-14
UA80396C2 (en) 2007-09-25
ZA200308172B (en) 2004-10-21
MXPA03010743A (es) 2004-03-02
BG66395B1 (bg) 2013-12-31
EA200301299A1 (ru) 2004-04-29
ES2617084T3 (es) 2017-06-15
HRP20030842A2 (en) 2005-08-31
PT1390070T (pt) 2017-03-01
HUP0304067A2 (hu) 2004-03-29
WO2002096456A1 (en) 2002-12-05
IL159014A0 (en) 2004-05-12
NO20035160L (no) 2003-11-20
HK1069762A1 (en) 2005-06-03
EP1390070B1 (en) 2017-02-08
JP2004534777A (ja) 2004-11-18
HU230294B1 (hu) 2015-12-28
ME00550B (me) 2011-10-10
DK1390070T3 (en) 2017-04-24
NO20035160D0 (no) 2003-11-20
HUP0304067A3 (en) 2006-01-30
CA2445664C (en) 2012-03-06
US20040191247A1 (en) 2004-09-30
CY1119190T1 (el) 2018-02-14
CZ307321B6 (cs) 2018-06-06
KR20040030625A (ko) 2004-04-09
SK16032003A3 (sk) 2004-05-04
BG108451A (en) 2005-02-28
CA2445664A1 (en) 2002-12-05
AU2002314103B2 (en) 2007-07-12
CN1305529C (zh) 2007-03-21
HRP20030842B1 (hr) 2017-06-02
SK288413B6 (sk) 2016-10-03
EA006744B1 (ru) 2006-04-28
CN1535160A (zh) 2004-10-06
EE200300582A (et) 2004-02-16
AU2002314103B8 (en) 2002-12-09
BR0210007A (pt) 2004-08-10
LT1390070T (lt) 2017-03-10
RS56006B1 (sr) 2017-09-29

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