NO323780B1 - Nye krystallinske former av en triazolo(4,5-D)pyrimidinforbindelse, fremgangsmate for fremstilling og anvendelser av slike samt farmasoytisk preparat inneholdende nevnte nye forbindelser. - Google Patents
Nye krystallinske former av en triazolo(4,5-D)pyrimidinforbindelse, fremgangsmate for fremstilling og anvendelser av slike samt farmasoytisk preparat inneholdende nevnte nye forbindelser. Download PDFInfo
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- NO323780B1 NO323780B1 NO20025756A NO20025756A NO323780B1 NO 323780 B1 NO323780 B1 NO 323780B1 NO 20025756 A NO20025756 A NO 20025756A NO 20025756 A NO20025756 A NO 20025756A NO 323780 B1 NO323780 B1 NO 323780B1
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- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
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- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
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- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000001476 sodium potassium tartrate Substances 0.000 description 1
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB0013407.2A GB0013407D0 (en) | 2000-06-02 | 2000-06-02 | Forms of a chemical compound |
PCT/SE2001/001239 WO2001092262A1 (en) | 2000-06-02 | 2001-05-31 | New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound |
Publications (3)
Publication Number | Publication Date |
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NO20025756D0 NO20025756D0 (no) | 2002-11-29 |
NO20025756L NO20025756L (no) | 2003-01-24 |
NO323780B1 true NO323780B1 (no) | 2007-07-02 |
Family
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20025756A NO323780B1 (no) | 2000-06-02 | 2002-11-29 | Nye krystallinske former av en triazolo(4,5-D)pyrimidinforbindelse, fremgangsmate for fremstilling og anvendelser av slike samt farmasoytisk preparat inneholdende nevnte nye forbindelser. |
NO20071547A NO332306B1 (no) | 2000-06-02 | 2007-03-23 | Nye krystallinske former av en triazolo(4,5-D)pyrimidinforbindelse, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk sammensetning |
NO20120595A NO333289B1 (no) | 2000-06-02 | 2012-05-14 | Blanding av vesentlig krystallinske former av en triazolo(4,5-D)pyrimidinforbindelse, farmasoytisk sammensetning samt anvendelser derav |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20071547A NO332306B1 (no) | 2000-06-02 | 2007-03-23 | Nye krystallinske former av en triazolo(4,5-D)pyrimidinforbindelse, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytisk sammensetning |
NO20120595A NO333289B1 (no) | 2000-06-02 | 2012-05-14 | Blanding av vesentlig krystallinske former av en triazolo(4,5-D)pyrimidinforbindelse, farmasoytisk sammensetning samt anvendelser derav |
Country Status (36)
Country | Link |
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US (3) | US20030181469A1 (sk) |
EP (3) | EP1493745B2 (sk) |
JP (3) | JP5036947B2 (sk) |
KR (1) | KR100781864B1 (sk) |
CN (2) | CN1817883B (sk) |
AR (2) | AR032335A1 (sk) |
AT (2) | ATE555115T1 (sk) |
AU (4) | AU2001262874B2 (sk) |
BG (3) | BG65837B1 (sk) |
BR (1) | BR0111328A (sk) |
CA (1) | CA2408596C (sk) |
CY (1) | CY1113047T1 (sk) |
CZ (2) | CZ304347B6 (sk) |
DE (1) | DE60117972T2 (sk) |
DK (2) | DK1289992T3 (sk) |
EE (1) | EE05222B1 (sk) |
ES (2) | ES2259031T3 (sk) |
GB (1) | GB0013407D0 (sk) |
HK (2) | HK1052347B (sk) |
HU (2) | HU230471B1 (sk) |
IL (4) | IL152777A0 (sk) |
IS (2) | IS2609B (sk) |
MX (1) | MXPA02011795A (sk) |
MY (2) | MY140674A (sk) |
NO (3) | NO323780B1 (sk) |
NZ (1) | NZ522638A (sk) |
PH (1) | PH12011000127A1 (sk) |
PL (2) | PL392882A1 (sk) |
PT (2) | PT1289992E (sk) |
RU (3) | RU2325391C2 (sk) |
SG (1) | SG135965A1 (sk) |
SI (2) | SI1493745T1 (sk) |
SK (1) | SK287817B6 (sk) |
UA (1) | UA73181C2 (sk) |
WO (1) | WO2001092262A1 (sk) |
ZA (1) | ZA200209324B (sk) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
GB0013488D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
JP4298212B2 (ja) * | 2002-03-29 | 2009-07-15 | 大日本印刷株式会社 | 塩酸エピナスチン高融点型結晶の製造法 |
TWI482772B (zh) * | 2006-08-21 | 2015-05-01 | Astrazeneca Ab | 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物 |
US20080045548A1 (en) * | 2006-08-21 | 2008-02-21 | Astrazeneca Ab | Pharmaceutical Compositions |
CA2668180A1 (en) * | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica N.V. | Triazolopyrimidine derivatives as adp p2y12 receptor antagonists |
EP2591783A1 (en) * | 2007-04-13 | 2013-05-15 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor |
TWI496776B (zh) * | 2007-11-15 | 2015-08-21 | Astrazeneca Ab | 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法 |
UA100864C2 (uk) * | 2007-12-03 | 2013-02-11 | Астразенека Аб | Спосіб лікування або запобігання аневризмі черевної аорти |
SG196805A1 (en) | 2008-09-09 | 2014-02-13 | Astrazeneca Ab | A process for preparing [1s- [1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates |
WO2011017108A2 (en) | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
WO2011067571A1 (en) * | 2009-12-03 | 2011-06-09 | Astrazeneca Ab | Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor |
CA2785487C (en) | 2009-12-23 | 2017-11-28 | Ratiopharm Gmbh | Solid pharmaceutical dosage form of ticagrelor |
CZ2011229A3 (cs) | 2011-04-19 | 2012-08-15 | Zentiva, K.S. | Opticky aktivní soli (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyklopenta-[d][1,3]dioxol-4-olu a zpusob jejich prípravy |
CN103764149A (zh) | 2011-06-01 | 2014-04-30 | 阿斯利康(瑞典)有限公司 | 新型替卡格雷共晶 |
AU2012343928A1 (en) * | 2011-11-30 | 2014-05-29 | Actavis Group Ptc Ehf | Novel crystalline form of ticagrelor and process for the preparation thereof |
EP2834247A4 (en) | 2012-04-05 | 2016-03-30 | Reddys Lab Ltd Dr | PREPARATION OF TICAGRELOR |
WO2014000719A1 (en) * | 2012-06-29 | 2014-01-03 | Zentiva, K.S. | Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl)cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol |
EP2870155B1 (en) | 2012-07-04 | 2016-08-24 | LEK Pharmaceuticals d.d. | Ticagrelor adducts with divalent metal salts |
CZ2012705A3 (cs) | 2012-10-16 | 2014-04-23 | Zentiva, K.S. | Pevná orální farmaceutická formulace obsahující ticagrelor |
CN103772393B (zh) * | 2012-10-18 | 2017-08-04 | 博瑞生物医药(苏州)股份有限公司 | 替卡格雷的晶型及其制备方法 |
WO2014083139A1 (en) * | 2012-11-29 | 2014-06-05 | Actavis Group Ptc Ehf | Novel amorphous form of ticagrelor |
CN103848836B (zh) * | 2012-12-07 | 2016-08-03 | 天津市汉康医药生物技术有限公司 | 替卡格雷倍半水合物及其制备方法 |
WO2014118808A2 (en) * | 2013-02-04 | 2014-08-07 | Hetero Research Foundation | Ticagrelor solid dispersion |
CZ307217B6 (cs) | 2013-03-14 | 2018-04-04 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy ticagreloru |
WO2014155389A2 (en) * | 2013-03-25 | 2014-10-02 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of ticagrelor |
CN104098570A (zh) * | 2013-04-07 | 2014-10-15 | 杭州领业医药科技有限公司 | 替卡格雷晶型及其制备方法和用途 |
CN104098572A (zh) * | 2013-04-08 | 2014-10-15 | 博瑞生物医药技术(苏州)有限公司 | 替卡格雷共晶型 |
CN104098553B (zh) * | 2013-04-10 | 2017-11-28 | 江苏恒瑞医药股份有限公司 | 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法 |
EP2813216A1 (en) | 2013-06-10 | 2014-12-17 | Zentiva, a.s. | Stabilized amorphous ticagrelor |
WO2014170026A1 (en) | 2013-04-18 | 2014-10-23 | Zentiva, K.S. | Stabilized amorphous ticagrelor |
CA2913326A1 (en) | 2013-05-29 | 2014-12-04 | Ratiopharm Gmbh | Solid pharmaceutical dosage form |
CN106496235A (zh) * | 2013-06-03 | 2017-03-15 | 杭州领业医药科技有限公司 | 结晶形态的三唑[4,5‑d]嘧啶化合物及其制备方法和用途 |
WO2014195861A2 (en) * | 2013-06-04 | 2014-12-11 | Dr. Reddy’S Laboratories Limited | Preparation of ticagrelor |
EP2816043A1 (en) | 2013-06-21 | 2014-12-24 | LEK Pharmaceuticals d.d. | Spherical ticagrelor particles |
WO2015001489A1 (en) * | 2013-07-01 | 2015-01-08 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of ticagrelor |
CN104341423B (zh) * | 2013-08-02 | 2017-03-01 | 上海京新生物医药有限公司 | 替格瑞洛的一水合物及其制备方法与在制药中的应用 |
CN104370912A (zh) * | 2013-08-13 | 2015-02-25 | 开原亨泰制药股份有限公司 | 替卡格雷多晶型体及其制备方法 |
WO2015037016A2 (en) * | 2013-09-10 | 2015-03-19 | Laurus Labs Private Limited | An improved process for the preparation of ticagrelor and intermediates thereof |
CZ2013866A3 (cs) | 2013-11-08 | 2015-05-20 | Zentiva, K.S. | Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru |
CN104650085A (zh) * | 2013-11-22 | 2015-05-27 | 天津市汉康医药生物技术有限公司 | 替卡格雷倍半水合物化合物 |
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