NO319048B1 - Kombinasjonspreparat av endotelinantagonist og beta-reseptorblokker, fremgangsmate for fremstilling derav samt anvendelse derav for behandling av sykdommer. - Google Patents
Kombinasjonspreparat av endotelinantagonist og beta-reseptorblokker, fremgangsmate for fremstilling derav samt anvendelse derav for behandling av sykdommer. Download PDFInfo
- Publication number
- NO319048B1 NO319048B1 NO20001634A NO20001634A NO319048B1 NO 319048 B1 NO319048 B1 NO 319048B1 NO 20001634 A NO20001634 A NO 20001634A NO 20001634 A NO20001634 A NO 20001634A NO 319048 B1 NO319048 B1 NO 319048B1
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- beta
- combination
- endothelin antagonist
- diseases
- Prior art date
Links
- 239000002876 beta blocker Substances 0.000 title claims abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 11
- 201000010099 disease Diseases 0.000 title claims abstract description 8
- 239000002308 endothelin receptor antagonist Substances 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title claims description 11
- 238000000034 method Methods 0.000 title description 2
- 239000005557 antagonist Substances 0.000 claims abstract description 6
- 206010047139 Vasoconstriction Diseases 0.000 claims description 10
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- 239000000825 pharmaceutical preparation Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 3
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- 125000001424 substituent group Chemical group 0.000 claims description 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- OUJTZYPIHDYQMC-LJQANCHMSA-N ambrisentan Chemical group O([C@@H](C(OC)(C=1C=CC=CC=1)C=1C=CC=CC=1)C(O)=O)C1=NC(C)=CC(C)=N1 OUJTZYPIHDYQMC-LJQANCHMSA-N 0.000 claims 1
- FEJVSJIALLTFRP-LJQANCHMSA-N darusentan Chemical compound COC1=CC(OC)=NC(O[C@H](C(O)=O)C(OC)(C=2C=CC=CC=2)C=2C=CC=CC=2)=N1 FEJVSJIALLTFRP-LJQANCHMSA-N 0.000 claims 1
- 102000002045 Endothelin Human genes 0.000 abstract description 6
- 108050009340 Endothelin Proteins 0.000 abstract description 6
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract description 6
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- GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 description 1
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- 150000001298 alcohols Chemical class 0.000 description 1
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- BQXQGZPYHWWCEB-UHFFFAOYSA-N carazolol Chemical compound N1C2=CC=CC=C2C2=C1C=CC=C2OCC(O)CNC(C)C BQXQGZPYHWWCEB-UHFFFAOYSA-N 0.000 description 1
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- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
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- VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 1
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- KQXKVJAGOJTNJS-HNNXBMFYSA-N penbutolol Chemical compound CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 KQXKVJAGOJTNJS-HNNXBMFYSA-N 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
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- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19743143A DE19743143A1 (de) | 1997-09-30 | 1997-09-30 | Pharmazeutische Kombinationspräparate |
| PCT/EP1998/005772 WO1999016444A1 (de) | 1997-09-30 | 1998-09-10 | Endothelin-antagonist und betarezeptorenblocker als kombinationspräparate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20001634D0 NO20001634D0 (no) | 2000-03-29 |
| NO20001634L NO20001634L (no) | 2000-03-29 |
| NO319048B1 true NO319048B1 (no) | 2005-06-06 |
Family
ID=7844115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20001634A NO319048B1 (no) | 1997-09-30 | 2000-03-29 | Kombinasjonspreparat av endotelinantagonist og beta-reseptorblokker, fremgangsmate for fremstilling derav samt anvendelse derav for behandling av sykdommer. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6352992B1 (ru) |
| EP (1) | EP1019055B1 (ru) |
| JP (1) | JP4608093B2 (ru) |
| KR (1) | KR100623122B1 (ru) |
| CN (1) | CN1149087C (ru) |
| AT (1) | ATE239479T1 (ru) |
| AU (1) | AU739860B2 (ru) |
| BR (1) | BR9812404A (ru) |
| CA (1) | CA2304698C (ru) |
| CZ (1) | CZ298745B6 (ru) |
| DE (2) | DE19743143A1 (ru) |
| ES (1) | ES2199461T3 (ru) |
| HK (1) | HK1032355A1 (ru) |
| HU (1) | HU226745B1 (ru) |
| NO (1) | NO319048B1 (ru) |
| RU (1) | RU2213577C2 (ru) |
| WO (1) | WO1999016444A1 (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DK1243262T3 (da) | 2001-03-20 | 2006-10-02 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter |
| EP1243263B1 (en) | 2001-03-21 | 2002-11-27 | Schwarz Pharma Ag | Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain |
| KR20070007931A (ko) | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
| EA014055B1 (ru) | 2004-08-27 | 2010-08-30 | Шварц Фарма Аг | Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами |
| US20070196510A1 (en) * | 2006-02-17 | 2007-08-23 | Gerber Michael J | Method for treating resistant hypertension |
| TWI397417B (zh) | 2006-06-15 | 2013-06-01 | Ucb Pharma Gmbh | 具有協同抗驚厥功效之醫藥組成物 |
| CA2904447C (en) | 2007-08-22 | 2017-01-03 | Abbvie Deutschland Gmbh & Co Kg | Therapy for complications of diabetes |
| CN104887645B (zh) * | 2015-06-15 | 2016-12-14 | 吉林万通药业集团梅河药业股份有限公司 | 阿莫西林胶囊及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4786441A (en) * | 1987-08-24 | 1988-11-22 | International Business Machines Corporation | Preparation of iodonium and sulfonium triflates |
| SE8704081D0 (sv) * | 1987-10-21 | 1987-10-21 | Haessle Ab | A new prohylactic method |
| ATE189217T1 (de) * | 1993-03-19 | 2000-02-15 | Merck & Co Inc | Phenoxyphenylessigsäurederivate |
| WO1995020568A1 (en) * | 1994-01-28 | 1995-08-03 | Cal International Limited | Pharmaceutical product comprising a salicylate of an esterifiable beta-blocker |
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| EP1609477B1 (en) | 1994-12-12 | 2011-11-09 | Omeros Corporation | Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure |
| NZ298853A (en) | 1995-01-27 | 1998-07-28 | Rhone Poulenc Rorer Ltd | 5-[2-cyano-phenoxy]-2-phenyl-acetic acid derivatives |
| DE19636046A1 (de) * | 1996-09-05 | 1998-03-12 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
| DE19652374A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
| KR20000057642A (ko) * | 1996-12-18 | 2000-09-25 | 스타르크, 카르크 | 헤테로시클릭 카르복실산 유도체, 그의 제제 및 엔도텔린 수용체길항제로서의 용도 |
-
1997
- 1997-09-30 DE DE19743143A patent/DE19743143A1/de not_active Withdrawn
-
1998
- 1998-09-10 US US09/508,989 patent/US6352992B1/en not_active Expired - Lifetime
- 1998-09-10 AT AT98945323T patent/ATE239479T1/de active
- 1998-09-10 CN CNB988097273A patent/CN1149087C/zh not_active Expired - Fee Related
- 1998-09-10 KR KR1020007003346A patent/KR100623122B1/ko not_active IP Right Cessation
- 1998-09-10 EP EP98945323A patent/EP1019055B1/de not_active Expired - Lifetime
- 1998-09-10 ES ES98945323T patent/ES2199461T3/es not_active Expired - Lifetime
- 1998-09-10 BR BR9812404-8A patent/BR9812404A/pt active Search and Examination
- 1998-09-10 CA CA002304698A patent/CA2304698C/en not_active Expired - Fee Related
- 1998-09-10 AU AU92672/98A patent/AU739860B2/en not_active Ceased
- 1998-09-10 CZ CZ20001081A patent/CZ298745B6/cs not_active IP Right Cessation
- 1998-09-10 HU HU0004590A patent/HU226745B1/hu not_active IP Right Cessation
- 1998-09-10 RU RU2000111500/14A patent/RU2213577C2/ru not_active IP Right Cessation
- 1998-09-10 WO PCT/EP1998/005772 patent/WO1999016444A1/de active IP Right Grant
- 1998-09-10 JP JP2000513580A patent/JP4608093B2/ja not_active Expired - Fee Related
- 1998-09-10 DE DE59808297T patent/DE59808297D1/de not_active Expired - Lifetime
-
2000
- 2000-03-29 NO NO20001634A patent/NO319048B1/no not_active IP Right Cessation
-
2001
- 2001-04-25 HK HK01102973A patent/HK1032355A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1272786A (zh) | 2000-11-08 |
| AU739860B2 (en) | 2001-10-25 |
| KR100623122B1 (ko) | 2006-09-12 |
| RU2213577C2 (ru) | 2003-10-10 |
| ATE239479T1 (de) | 2003-05-15 |
| EP1019055A1 (de) | 2000-07-19 |
| ES2199461T3 (es) | 2004-02-16 |
| CZ298745B6 (cs) | 2008-01-16 |
| BR9812404A (pt) | 2000-09-19 |
| NO20001634D0 (no) | 2000-03-29 |
| EP1019055B1 (de) | 2003-05-07 |
| KR20010015650A (ko) | 2001-02-26 |
| CA2304698A1 (en) | 1999-04-08 |
| HUP0004590A2 (hu) | 2001-11-28 |
| CA2304698C (en) | 2008-02-19 |
| DE19743143A1 (de) | 1999-04-01 |
| NO20001634L (no) | 2000-03-29 |
| AU9267298A (en) | 1999-04-23 |
| DE59808297D1 (de) | 2003-06-12 |
| JP2001517703A (ja) | 2001-10-09 |
| US6352992B1 (en) | 2002-03-05 |
| HUP0004590A3 (en) | 2002-01-28 |
| HU226745B1 (en) | 2009-09-28 |
| CZ20001081A3 (en) | 2001-05-16 |
| WO1999016444A1 (de) | 1999-04-08 |
| HK1032355A1 (en) | 2001-07-20 |
| JP4608093B2 (ja) | 2011-01-05 |
| CN1149087C (zh) | 2004-05-12 |
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Legal Events
| Date | Code | Title | Description |
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| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: ABBVIE DEUTSCHLAND GMBH & CO AG, DE |
|
| MM1K | Lapsed by not paying the annual fees |