CN1149087C - 内皮素拮抗剂和β-受体阻滞剂的组合制剂 - Google Patents

内皮素拮抗剂和β-受体阻滞剂的组合制剂 Download PDF

Info

Publication number
CN1149087C
CN1149087C CNB988097273A CN98809727A CN1149087C CN 1149087 C CN1149087 C CN 1149087C CN B988097273 A CNB988097273 A CN B988097273A CN 98809727 A CN98809727 A CN 98809727A CN 1149087 C CN1149087 C CN 1149087C
Authority
CN
China
Prior art keywords
endothelin antagonist
combination
beta
blocker
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988097273A
Other languages
English (en)
Chinese (zh)
Other versions
CN1272786A (zh
Inventor
M
M·基申加斯特
ض�
K·明特尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Ltd By Share Ltd
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Publication of CN1272786A publication Critical patent/CN1272786A/zh
Application granted granted Critical
Publication of CN1149087C publication Critical patent/CN1149087C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CNB988097273A 1997-09-30 1998-09-10 内皮素拮抗剂和β-受体阻滞剂的组合制剂 Expired - Fee Related CN1149087C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19743143.7 1997-09-30
DE19743143A DE19743143A1 (de) 1997-09-30 1997-09-30 Pharmazeutische Kombinationspräparate

Publications (2)

Publication Number Publication Date
CN1272786A CN1272786A (zh) 2000-11-08
CN1149087C true CN1149087C (zh) 2004-05-12

Family

ID=7844115

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988097273A Expired - Fee Related CN1149087C (zh) 1997-09-30 1998-09-10 内皮素拮抗剂和β-受体阻滞剂的组合制剂

Country Status (17)

Country Link
US (1) US6352992B1 (ru)
EP (1) EP1019055B1 (ru)
JP (1) JP4608093B2 (ru)
KR (1) KR100623122B1 (ru)
CN (1) CN1149087C (ru)
AT (1) ATE239479T1 (ru)
AU (1) AU739860B2 (ru)
BR (1) BR9812404A (ru)
CA (1) CA2304698C (ru)
CZ (1) CZ298745B6 (ru)
DE (2) DE19743143A1 (ru)
ES (1) ES2199461T3 (ru)
HK (1) HK1032355A1 (ru)
HU (1) HU226745B1 (ru)
NO (1) NO319048B1 (ru)
RU (1) RU2213577C2 (ru)
WO (1) WO1999016444A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DK1243262T3 (da) 2001-03-20 2006-10-02 Sanol Arznei Schwarz Gmbh Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter
EP1243263B1 (en) 2001-03-21 2002-11-27 Schwarz Pharma Ag Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain
KR20070007931A (ko) 2004-04-16 2007-01-16 쉬바르츠파르마에이지 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EA014055B1 (ru) 2004-08-27 2010-08-30 Шварц Фарма Аг Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами
US20070196510A1 (en) * 2006-02-17 2007-08-23 Gerber Michael J Method for treating resistant hypertension
TWI397417B (zh) 2006-06-15 2013-06-01 Ucb Pharma Gmbh 具有協同抗驚厥功效之醫藥組成物
CA2904447C (en) 2007-08-22 2017-01-03 Abbvie Deutschland Gmbh & Co Kg Therapy for complications of diabetes
CN104887645B (zh) * 2015-06-15 2016-12-14 吉林万通药业集团梅河药业股份有限公司 阿莫西林胶囊及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786441A (en) * 1987-08-24 1988-11-22 International Business Machines Corporation Preparation of iodonium and sulfonium triflates
SE8704081D0 (sv) * 1987-10-21 1987-10-21 Haessle Ab A new prohylactic method
ATE189217T1 (de) * 1993-03-19 2000-02-15 Merck & Co Inc Phenoxyphenylessigsäurederivate
WO1995020568A1 (en) * 1994-01-28 1995-08-03 Cal International Limited Pharmaceutical product comprising a salicylate of an esterifiable beta-blocker
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
EP1609477B1 (en) 1994-12-12 2011-11-09 Omeros Corporation Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure
NZ298853A (en) 1995-01-27 1998-07-28 Rhone Poulenc Rorer Ltd 5-[2-cyano-phenoxy]-2-phenyl-acetic acid derivatives
DE19636046A1 (de) * 1996-09-05 1998-03-12 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
DE19652374A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung
KR20000057642A (ko) * 1996-12-18 2000-09-25 스타르크, 카르크 헤테로시클릭 카르복실산 유도체, 그의 제제 및 엔도텔린 수용체길항제로서의 용도

Also Published As

Publication number Publication date
CN1272786A (zh) 2000-11-08
AU739860B2 (en) 2001-10-25
KR100623122B1 (ko) 2006-09-12
RU2213577C2 (ru) 2003-10-10
ATE239479T1 (de) 2003-05-15
EP1019055A1 (de) 2000-07-19
ES2199461T3 (es) 2004-02-16
CZ298745B6 (cs) 2008-01-16
BR9812404A (pt) 2000-09-19
NO20001634D0 (no) 2000-03-29
EP1019055B1 (de) 2003-05-07
KR20010015650A (ko) 2001-02-26
CA2304698A1 (en) 1999-04-08
HUP0004590A2 (hu) 2001-11-28
CA2304698C (en) 2008-02-19
DE19743143A1 (de) 1999-04-01
NO20001634L (no) 2000-03-29
NO319048B1 (no) 2005-06-06
AU9267298A (en) 1999-04-23
DE59808297D1 (de) 2003-06-12
JP2001517703A (ja) 2001-10-09
US6352992B1 (en) 2002-03-05
HUP0004590A3 (en) 2002-01-28
HU226745B1 (en) 2009-09-28
CZ20001081A3 (en) 2001-05-16
WO1999016444A1 (de) 1999-04-08
HK1032355A1 (en) 2001-07-20
JP4608093B2 (ja) 2011-01-05

Similar Documents

Publication Publication Date Title
CN1102388C (zh) 用羟基咔唑化合物抑制平滑肌的移行与增生
AU2008267058C1 (en) Treatment of pulmonary hypertension with carbonic anhydrase inhibitors in combination with a sympathomimetic amine
RU2470643C2 (ru) Способы применения антагонистов вазопрессина с антрациклиновыми химиотерапевтическими средствами для снижения кардиотоксичности и/или улучшения выживания
TWI519531B (zh) 阿齊沙坦有機胺鹽及其製備方法和用途
KR20120046216A (ko) 3-시아노퀴놀린 정제 제형 및 이의 용도
CN1149087C (zh) 内皮素拮抗剂和β-受体阻滞剂的组合制剂
JP2013216708A (ja) ネコの全身性疾患の予防又は治療の為のアンジオテンシンii受容体アンタゴニスト
TW202202139A (zh) 以2-〔(4-{6-〔(4-氰基-2-氟苄基)氧基〕吡啶-2-基}哌啶-1-基)甲基〕-1-〔(2s)-氧雜環丁烷-2-基甲基〕-1h-苯並咪唑-6-甲酸或其藥學上的鹽治療第2型糖尿病或肥胖症或體重過重
CN1956717A (zh) 用于口服的烟酸缓释组合物
CN1358092A (zh) 含有西布曲明和奥利司他的药物组合物
WO2004002473A1 (ja) 血糖コントロール用医薬組成物
TW201201800A (en) A pharmaceutical controlled release composition of losartan
EP2386301A1 (en) Pharmaceutical composition of levoamlodipine or pharmaceutically acceptable salts thereof and blockers, and use thereof
CN1319528C (zh) 用于预防心力衰竭的Na+-H+交换抑制剂卡立泊来德与ACE抑制剂雷米普利的联合制剂
EP1465607A1 (fr) Compositions pharmaceutiques a liberation modifiee
EP1274412A1 (en) Pharmaceutical formulation
CN112512526B (zh) 化合物a与化合物b联合在制备治疗痛风或高尿酸血症的药物中的用途
CZ20004698A3 (cs) Lék pro podporu skončení nebo omezení kouření nebo prevence recidivy kouření
CN1976696A (zh) 用于预防或治疗脂质代谢异常的医药组合物
WO2024128996A1 (en) Monolayer tablet composition of empagliflozin and metformin hydrochloride
US20190142786A1 (en) Methods of treating obesity in responder and non-responder populations
RU2690372C2 (ru) Лекарственные средства, содержащие диацереин, и способы снижения уровней мочевой кислоты в крови с его использованием
WO2007103563A2 (en) Pharmaceutical formulations containing metformin
PT2323633E (pt) Composição farmacêutica estável para a administração optimizada de um inibidor de união de hiv
TW201219035A (en) Pharmaceutical composition for the treatment of type 2 diabetes in mammals including human beings

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1032355

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: ABBVIE GERMANY GMBH + CO. KG

Free format text: FORMER OWNER: ABBOTT GMBH + CO KG

Effective date: 20130829

Owner name: ABBOTT GMBH + CO. KG

Free format text: FORMER OWNER: KNOLL AKTIENGESELLSCHAFT

Effective date: 20130829

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: KNOLL AKTIENGESELLSCHAFT

Free format text: FORMER NAME: KNOLL AG

Owner name: ABBOTT GMBH + CO KG

Free format text: FORMER NAME: ABBOTT GMBH + CO. KG

CP01 Change in the name or title of a patent holder

Address after: Wiesbaden

Patentee after: ABBOTT GmbH & Co.KG

Address before: Wiesbaden

Patentee before: Abbott Limited by Share Ltd.

Address after: Ludwigshafen, Germany

Patentee after: KNOLL GmbH

Address before: Ludwigshafen, Germany

Patentee before: KNORR-BREMSE GmbH

TR01 Transfer of patent right

Effective date of registration: 20130829

Address after: Wiesbaden

Patentee after: ABBOTT GmbH & Co.KG

Address before: Wiesbaden

Patentee before: ABBOTT GmbH & Co.KG

Effective date of registration: 20130829

Address after: Wiesbaden

Patentee after: Abbott Limited by Share Ltd.

Address before: Ludwigshafen, Germany

Patentee before: KNOLL GmbH

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040512

Termination date: 20140910

EXPY Termination of patent right or utility model