NO318765B1 - Anvendelse av en HMG-CoA reduktaseinhibitor og en insulinsensibilisator til fremstilling av et medikament for forebyggelse eller behandling av arteriosklerose eller xantom, samt pakket farmasoytisk preparat som omfatter de to midlene i separate porsjoner. - Google Patents
Anvendelse av en HMG-CoA reduktaseinhibitor og en insulinsensibilisator til fremstilling av et medikament for forebyggelse eller behandling av arteriosklerose eller xantom, samt pakket farmasoytisk preparat som omfatter de to midlene i separate porsjoner. Download PDFInfo
- Publication number
- NO318765B1 NO318765B1 NO19962784A NO962784A NO318765B1 NO 318765 B1 NO318765 B1 NO 318765B1 NO 19962784 A NO19962784 A NO 19962784A NO 962784 A NO962784 A NO 962784A NO 318765 B1 NO318765 B1 NO 318765B1
- Authority
- NO
- Norway
- Prior art keywords
- hmg
- use according
- coa reductase
- reductase inhibitor
- insulin sensitizer
- Prior art date
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- 229940122355 Insulin sensitizer Drugs 0.000 title claims abstract description 89
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- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
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- 229960003511 macrogol Drugs 0.000 description 1
- 229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
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- 235000019423 pullulan Nutrition 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000011555 rabbit model Methods 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
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- NGHMEZWZOZEZOH-UHFFFAOYSA-N silicic acid;hydrate Chemical compound O.O[Si](O)(O)O NGHMEZWZOZEZOH-UHFFFAOYSA-N 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
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- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Glass Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16729195 | 1995-07-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO962784D0 NO962784D0 (no) | 1996-07-02 |
| NO962784L NO962784L (no) | 1997-01-06 |
| NO318765B1 true NO318765B1 (no) | 2005-05-02 |
Family
ID=15847039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19962784A NO318765B1 (no) | 1995-07-03 | 1996-07-02 | Anvendelse av en HMG-CoA reduktaseinhibitor og en insulinsensibilisator til fremstilling av et medikament for forebyggelse eller behandling av arteriosklerose eller xantom, samt pakket farmasoytisk preparat som omfatter de to midlene i separate porsjoner. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5798375A (de) |
| EP (1) | EP0753298B2 (de) |
| KR (1) | KR100424124B1 (de) |
| CN (1) | CN1089584C (de) |
| AT (1) | ATE209046T1 (de) |
| AU (1) | AU706628B2 (de) |
| CA (1) | CA2180296C (de) |
| CZ (1) | CZ286832B6 (de) |
| DE (1) | DE69617116T3 (de) |
| DK (1) | DK0753298T3 (de) |
| ES (1) | ES2165474T5 (de) |
| HK (1) | HK1011928A1 (de) |
| HU (1) | HUP9601808A3 (de) |
| IL (1) | IL118778A (de) |
| NO (1) | NO318765B1 (de) |
| NZ (1) | NZ286920A (de) |
| PT (1) | PT753298E (de) |
| RU (1) | RU2158607C2 (de) |
| TW (1) | TW474809B (de) |
| ZA (1) | ZA965650B (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438587B (en) * | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| ATE253903T1 (de) * | 1996-12-11 | 2003-11-15 | Dana Farber Cancer Inst Inc | Methoden und pharmazeutische zusammenstellungen zur wachstumsverhinderung von tumorzellen enthaltend einen ppar-gamma agonisten und einen map kinase inhibitor |
| US6011049A (en) * | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
| US5859037A (en) * | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
| GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| SI1009400T1 (en) * | 1997-08-29 | 2005-04-30 | Pfizer Inc. | Combination therapy comprising atorvastatin and an antihypertensive agent |
| GT199800127A (es) * | 1997-08-29 | 2000-02-01 | Combinaciones terapeuticas. | |
| NZ503794A (en) * | 1997-10-08 | 2002-09-27 | Sankyo Co | Benzimidazole and imidazopyridine derived heterocyclic compounds, pharmaceutical compositions and uses thereof |
| EP1047423B1 (de) * | 1997-11-19 | 2006-05-10 | Takeda Pharmaceutical Company Limited | Aptoptoseinhibitoren |
| US20030105154A1 (en) | 2001-10-24 | 2003-06-05 | Bisgaier Charles Larry | Statin-carboxyalkylether combinations |
| DE69919707T2 (de) | 1998-06-19 | 2005-09-01 | Chiron Corp., Emeryville | Glycogen synthase kinase 3 inhibitoren |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US7141602B2 (en) * | 1998-09-18 | 2006-11-28 | Lek Pharmaceuticals D.D. | Process for obtaining HMG-CoA reductase inhibitors of high purity |
| US6326396B1 (en) | 1998-11-20 | 2001-12-04 | Alteon, Inc. | Glucose and lipid lowering compounds |
| SI20109A (sl) * | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
| TWI284533B (en) | 1999-05-24 | 2007-08-01 | Sankyo Co | Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant |
| US6465011B2 (en) | 1999-05-29 | 2002-10-15 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
| US6372251B2 (en) * | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
| CN1378547A (zh) | 1999-10-11 | 2002-11-06 | 辉瑞大药厂 | 用作磷酸二酯酶抑制剂的5－(2－取代的－5－杂环基磺酰基吡啶－3－基)－二氢吡唑并[4,3－d]嘧啶－7－酮类化合物 |
| US20030060488A1 (en) * | 2000-02-10 | 2003-03-27 | Yasuo Sugiyama | Drug comprising combination |
| USRE44578E1 (en) | 2000-04-10 | 2013-11-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
| ATE524163T1 (de) * | 2000-04-10 | 2011-09-15 | Teva Pharma | Stabile pharmazeutische zusammensetzungen enthaltend 7-substituierte-3,5- dihydroxyheptansäuren oder 7-substituierte-3,5- dihydroxyheptensäuren |
| FR2807944B1 (fr) * | 2000-04-25 | 2003-06-13 | Solvay Pharma | Utilisation de l'anethole-dithiolethione dans la prevention et le traitement de la tenotoxicite induite par un medicament |
| JP2004501121A (ja) | 2000-06-09 | 2004-01-15 | エルイーケー ファーマシューティカルズ ディー．ディー． | 安定した医薬効果を有する合成物、及びそれを含む医薬製剤 |
| US6806290B2 (en) | 2000-06-09 | 2004-10-19 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
| TWI284529B (en) * | 2000-12-18 | 2007-08-01 | Sankyo Co | A composition for lowering triglyceride |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6452014B1 (en) * | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| WO2002051396A1 (fr) * | 2000-12-26 | 2002-07-04 | Sankyo Company, Limited | Compositions pharmaceutiques contenant des derives de cyclobutene |
| SK13022003A3 (sk) * | 2001-03-27 | 2004-03-02 | Ranbaxy Laboratories Limited | Stabilná farmaceutická kompozícia pravastatínu |
| US20040077689A1 (en) * | 2001-04-25 | 2004-04-22 | Yasuo Sugiyama | Abc expression promoters |
| US6486127B1 (en) | 2001-05-23 | 2002-11-26 | Insmed, Incorporated | Compositions comprising D-chiro inositol and lipid lowering compounds and methods of treatment thereof |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| US6987123B2 (en) | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
| AU2002336609B2 (en) * | 2001-09-21 | 2006-08-24 | Merck Sharp & Dohme Corp. | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US9060941B2 (en) | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7785627B2 (en) | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7235543B2 (en) | 2003-03-07 | 2007-06-26 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| CA2524134C (en) * | 2003-04-28 | 2017-07-04 | Sankyo Company Limited | Adiponectin production enhancer |
| EP1618893A4 (de) * | 2003-04-28 | 2009-08-12 | Sankyo Co | Mittel zur verstärkung der zuckeraufnahmefähigkeit |
| JP4901474B2 (ja) | 2003-05-30 | 2012-03-21 | ランバクシー ラボラトリーズ リミテッド | 置換ピロール誘導体 |
| NZ544307A (en) * | 2003-06-27 | 2008-12-24 | Reddy Research Foundation | Compositions comprising balaglitazone and further antidiabetic compounds |
| US6978908B2 (en) * | 2003-09-15 | 2005-12-27 | Gerber Products Company | Drinking vessel with adjustable handles |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| JP2005200419A (ja) * | 2004-01-16 | 2005-07-28 | National Health Research Inst | 癌治療法 |
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-
1996
- 1996-07-02 AU AU56261/96A patent/AU706628B2/en not_active Ceased
- 1996-07-02 IL IL11877896A patent/IL118778A/xx not_active IP Right Cessation
- 1996-07-02 RU RU96112769/14A patent/RU2158607C2/ru not_active IP Right Cessation
- 1996-07-02 TW TW085107984A patent/TW474809B/zh active
- 1996-07-02 US US08/676,090 patent/US5798375A/en not_active Expired - Lifetime
- 1996-07-02 CA CA002180296A patent/CA2180296C/en not_active Expired - Fee Related
- 1996-07-02 NO NO19962784A patent/NO318765B1/no not_active IP Right Cessation
- 1996-07-02 HU HU9601808A patent/HUP9601808A3/hu unknown
- 1996-07-02 NZ NZ286920A patent/NZ286920A/en not_active IP Right Cessation
- 1996-07-03 ZA ZA965650A patent/ZA965650B/xx unknown
- 1996-07-03 ES ES96304924T patent/ES2165474T5/es not_active Expired - Lifetime
- 1996-07-03 AT AT96304924T patent/ATE209046T1/de not_active IP Right Cessation
- 1996-07-03 CZ CZ19961982A patent/CZ286832B6/cs not_active IP Right Cessation
- 1996-07-03 CN CN96112170A patent/CN1089584C/zh not_active Expired - Fee Related
- 1996-07-03 PT PT96304924T patent/PT753298E/pt unknown
- 1996-07-03 DK DK96304924T patent/DK0753298T3/da active
- 1996-07-03 DE DE69617116T patent/DE69617116T3/de not_active Expired - Lifetime
- 1996-07-03 KR KR1019960026891A patent/KR100424124B1/ko not_active IP Right Cessation
- 1996-07-03 EP EP96304924A patent/EP0753298B2/de not_active Expired - Lifetime
-
1998
- 1998-04-16 US US09/061,446 patent/US6159997A/en not_active Expired - Lifetime
- 1998-12-10 HK HK98113080A patent/HK1011928A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL118778A0 (en) | 1996-10-31 |
| CA2180296C (en) | 2007-01-09 |
| NZ286920A (en) | 1997-06-24 |
| CZ198296A3 (en) | 1997-01-15 |
| NO962784L (no) | 1997-01-06 |
| AU5626196A (en) | 1997-01-16 |
| DE69617116T3 (de) | 2011-10-06 |
| ES2165474T3 (es) | 2002-03-16 |
| ES2165474T5 (es) | 2011-06-08 |
| CN1148492A (zh) | 1997-04-30 |
| DK0753298T3 (da) | 2002-05-21 |
| EP0753298A1 (de) | 1997-01-15 |
| HUP9601808A2 (en) | 1997-04-28 |
| DE69617116D1 (de) | 2002-01-03 |
| TW474809B (en) | 2002-02-01 |
| RU2158607C2 (ru) | 2000-11-10 |
| IL118778A (en) | 1999-07-14 |
| KR970005307A (ko) | 1997-02-19 |
| HUP9601808A3 (en) | 2000-06-28 |
| ATE209046T1 (de) | 2001-12-15 |
| CZ286832B6 (en) | 2000-07-12 |
| PT753298E (pt) | 2002-03-28 |
| CN1089584C (zh) | 2002-08-28 |
| EP0753298B1 (de) | 2001-11-21 |
| KR100424124B1 (ko) | 2004-06-26 |
| HK1011928A1 (en) | 1999-07-23 |
| DE69617116T2 (de) | 2002-08-29 |
| NO962784D0 (no) | 1996-07-02 |
| ZA965650B (en) | 1997-01-27 |
| CA2180296A1 (en) | 1997-01-04 |
| US6159997A (en) | 2000-12-12 |
| US5798375A (en) | 1998-08-25 |
| AU706628B2 (en) | 1999-06-17 |
| EP0753298B2 (de) | 2011-02-16 |
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