NO318384B1 - Nye Dolastatinderivater, deres fremstilling og anvendelse, samt farmasoytiske blandinger inneholdende disse. - Google Patents
Nye Dolastatinderivater, deres fremstilling og anvendelse, samt farmasoytiske blandinger inneholdende disse. Download PDFInfo
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- NO318384B1 NO318384B1 NO19975710A NO975710A NO318384B1 NO 318384 B1 NO318384 B1 NO 318384B1 NO 19975710 A NO19975710 A NO 19975710A NO 975710 A NO975710 A NO 975710A NO 318384 B1 NO318384 B1 NO 318384B1
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- val xab
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- 238000002360 preparation method Methods 0.000 title description 3
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- 238000000034 method Methods 0.000 claims description 27
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 11
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- 239000000829 suppository Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000004014 thioethyl group Chemical group [H]SC([H])([H])C([H])([H])* 0.000 description 1
- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/472,453 US5831002A (en) | 1992-05-20 | 1995-06-07 | Antitumor peptides |
| PCT/EP1996/002393 WO1996040752A1 (en) | 1995-06-07 | 1996-06-03 | Novel dolastatin derivatives, their preparation and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO975710D0 NO975710D0 (no) | 1997-12-05 |
| NO975710L NO975710L (no) | 1998-02-02 |
| NO318384B1 true NO318384B1 (no) | 2005-03-14 |
Family
ID=23875567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19975710A NO318384B1 (no) | 1995-06-07 | 1997-12-05 | Nye Dolastatinderivater, deres fremstilling og anvendelse, samt farmasoytiske blandinger inneholdende disse. |
| NO19975711A NO317670B1 (no) | 1995-06-07 | 1997-12-05 | Nye Dolastatinderivater, deres fremstilling og anvendelse |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19975711A NO317670B1 (no) | 1995-06-07 | 1997-12-05 | Nye Dolastatinderivater, deres fremstilling og anvendelse |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5831002A (xx) |
| EP (2) | EP0871656B1 (xx) |
| JP (2) | JP4221062B2 (xx) |
| KR (2) | KR100437985B1 (xx) |
| CN (2) | CN1182154C (xx) |
| AR (2) | AR003427A1 (xx) |
| AT (2) | ATE224910T1 (xx) |
| AU (2) | AU725170B2 (xx) |
| BG (2) | BG102125A (xx) |
| BR (2) | BR9609423A (xx) |
| CA (2) | CA2219818C (xx) |
| CO (2) | CO4700527A1 (xx) |
| CZ (2) | CZ293682B6 (xx) |
| DE (2) | DE69623992T2 (xx) |
| DK (2) | DK0832104T3 (xx) |
| ES (2) | ES2186783T3 (xx) |
| HR (2) | HRP960257A2 (xx) |
| HU (2) | HU228071B1 (xx) |
| IL (2) | IL122215A (xx) |
| MX (2) | MX9709147A (xx) |
| MY (2) | MY119042A (xx) |
| NO (2) | NO318384B1 (xx) |
| NZ (2) | NZ310444A (xx) |
| PL (2) | PL185762B1 (xx) |
| PT (2) | PT871656E (xx) |
| RO (2) | RO118953B1 (xx) |
| SI (2) | SI0832104T1 (xx) |
| SK (1) | SK282466B6 (xx) |
| TR (2) | TR199701545T1 (xx) |
| TW (2) | TW508357B (xx) |
| UA (2) | UA46776C2 (xx) |
| WO (2) | WO1996040751A1 (xx) |
| ZA (2) | ZA964710B (xx) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807984A (en) * | 1995-11-09 | 1998-09-15 | Basf Aktienegesellschaft | Oligopeptides, the preparation and use thereof |
| TW474946B (en) * | 1995-12-15 | 2002-02-01 | Basf Ag | Novel compounds, the preparation and use thereof |
| US20010009901A1 (en) * | 1996-12-11 | 2001-07-26 | Basf Aktiengesellschaft Germany | Antineoplastic peptides |
| US5965537A (en) * | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
| US6103698A (en) * | 1997-03-13 | 2000-08-15 | Basf Aktiengesellschaft | Dolastatin-15 derivatives in combination with taxanes |
| US6143721A (en) * | 1997-07-18 | 2000-11-07 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
| US6015790A (en) * | 1997-10-06 | 2000-01-18 | Basf Aktiengesellschaft | Methods and compositions for treating rheumatoid arthritis |
| US5985837A (en) * | 1998-07-08 | 1999-11-16 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
| US6395897B1 (en) | 1999-03-02 | 2002-05-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5 |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US7018642B2 (en) | 2001-04-27 | 2006-03-28 | The Procter & Gamble Company | Compounds, compositions, and methods for controlling biofilms |
| AU2002359792A1 (en) * | 2001-12-18 | 2003-06-30 | Proteologics, Inc. | Methods and compositions for the inhibition of viral release |
| WO2003072754A2 (en) * | 2002-02-27 | 2003-09-04 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use |
| WO2006013552A2 (en) | 2004-08-02 | 2006-02-09 | Ramot At Tel Aviv University Ltd. | Articles of peptide nanostructures and method of forming the same |
| CA2607940C (en) | 2005-05-18 | 2009-12-15 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| EP1924245A2 (en) * | 2005-08-19 | 2008-05-28 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Topical formulations of histone deacetylase inhibitors and methods of using the same |
| EP1973928A2 (en) * | 2005-10-11 | 2008-10-01 | Ramot at Tel-Aviv University Ltd. | Self-assembled fmoc-ff hydrogels |
| US8163792B2 (en) | 2006-05-16 | 2012-04-24 | Pharmascience Inc. | IAP BIR domain binding compounds |
| JP5452223B2 (ja) * | 2006-07-24 | 2014-03-26 | テトラロジック ファーマシューティカルズ コーポレーション | Ｉａｐ阻害剤 |
| CN101674835B (zh) * | 2007-04-12 | 2013-12-11 | 台湾神隆股份有限公司 | 制备加兰他敏的方法 |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| SG10201501095WA (en) | 2010-02-12 | 2015-04-29 | Pharmascience Inc | Iap bir domain binding compounds |
| CA2822556A1 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
| CN103380132B (zh) | 2010-12-30 | 2016-08-31 | 益安药业 | 菲啶大环丙型肝炎丝氨酸蛋白酶抑制剂 |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| EA201391756A1 (ru) * | 2011-05-27 | 2014-05-30 | Амбркс, Инк. | Композиции, содержащие, способы, включающие, и применение производных доластатина, связанных с неприродными аминокислотами |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| MX2024002571A (es) | 2021-09-03 | 2024-03-20 | Toray Industries | Composicion farmaceutica para tratamiento y/o prevencion de cancer. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US4879278A (en) * | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| DK0934950T3 (da) * | 1991-08-09 | 2002-07-29 | Teikoku Hormone Mfg Co Ltd | Tetrapeptidderivat |
| CZ292612B6 (cs) * | 1992-05-20 | 2003-11-12 | Abbott Gmbh & Co. Kg | Peptid s protirakovinnou aktivitou, jeho použití a farmaceutický prostředek s obsahem takového peptidu |
| US5530097A (en) * | 1994-08-01 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory peptide amides |
| US5504191A (en) * | 1994-08-01 | 1996-04-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide methyl esters |
-
1995
- 1995-06-07 US US08/472,453 patent/US5831002A/en not_active Expired - Lifetime
-
1996
- 1996-06-03 TR TR97/01545T patent/TR199701545T1/xx unknown
- 1996-06-03 WO PCT/EP1996/002392 patent/WO1996040751A1/en active IP Right Grant
- 1996-06-03 PT PT96918661T patent/PT871656E/pt unknown
- 1996-06-03 NZ NZ310444A patent/NZ310444A/xx not_active IP Right Cessation
- 1996-06-03 HU HU9801910A patent/HU228071B1/hu not_active IP Right Cessation
- 1996-06-03 EP EP96918661A patent/EP0871656B1/en not_active Expired - Lifetime
- 1996-06-03 EP EP96918660A patent/EP0832104B1/en not_active Expired - Lifetime
- 1996-06-03 MY MYPI96002155A patent/MY119042A/en unknown
- 1996-06-03 MX MX9709147A patent/MX9709147A/es unknown
- 1996-06-03 CN CNB961944676A patent/CN1182154C/zh not_active Expired - Fee Related
- 1996-06-03 DK DK96918660T patent/DK0832104T3/da active
- 1996-06-03 AT AT96918661T patent/ATE224910T1/de active
- 1996-06-03 IL IL12221596A patent/IL122215A/xx not_active IP Right Cessation
- 1996-06-03 BR BR9609423A patent/BR9609423A/pt not_active Application Discontinuation
- 1996-06-03 AU AU61242/96A patent/AU725170B2/en not_active Ceased
- 1996-06-03 HU HU9801817A patent/HU228073B1/hu not_active IP Right Cessation
- 1996-06-03 AU AU61241/96A patent/AU725164B2/en not_active Ceased
- 1996-06-03 CZ CZ19973763A patent/CZ293682B6/cs not_active IP Right Cessation
- 1996-06-03 ES ES96918660T patent/ES2186783T3/es not_active Expired - Lifetime
- 1996-06-03 DK DK96918661T patent/DK0871656T3/da active
- 1996-06-03 KR KR1019970709063A patent/KR100437985B1/ko not_active IP Right Cessation
- 1996-06-03 CZ CZ19973765A patent/CZ293683B6/cs not_active IP Right Cessation
- 1996-06-03 SI SI9630539T patent/SI0832104T1/xx unknown
- 1996-06-03 AT AT96918660T patent/ATE223431T1/de active
- 1996-06-03 PT PT96918660T patent/PT832104E/pt unknown
- 1996-06-03 RO RO97-02264A patent/RO118953B1/ro unknown
- 1996-06-03 RO RO97-02254A patent/RO119783B1/ro unknown
- 1996-06-03 JP JP50013297A patent/JP4221062B2/ja not_active Expired - Fee Related
- 1996-06-03 NZ NZ310443A patent/NZ310443A/en not_active IP Right Cessation
- 1996-06-03 UA UA98010070A patent/UA46776C2/uk unknown
- 1996-06-03 JP JP50013197A patent/JP3957751B2/ja not_active Expired - Fee Related
- 1996-06-03 WO PCT/EP1996/002393 patent/WO1996040752A1/en active IP Right Grant
- 1996-06-03 PL PL96323723A patent/PL185762B1/pl unknown
- 1996-06-03 SK SK1653-97A patent/SK282466B6/sk not_active IP Right Cessation
- 1996-06-03 CA CA002219818A patent/CA2219818C/en not_active Expired - Fee Related
- 1996-06-03 DE DE69623992T patent/DE69623992T2/de not_active Expired - Lifetime
- 1996-06-03 ES ES96918661T patent/ES2188759T3/es not_active Expired - Lifetime
- 1996-06-03 PL PL96323726A patent/PL185763B1/pl unknown
- 1996-06-03 CA CA002219819A patent/CA2219819C/en not_active Expired - Fee Related
- 1996-06-03 DE DE69623472T patent/DE69623472T2/de not_active Expired - Lifetime
- 1996-06-03 TR TR97/01544T patent/TR199701544T1/xx unknown
- 1996-06-03 KR KR1019970709064A patent/KR100437986B1/ko not_active IP Right Cessation
- 1996-06-03 SI SI9630550T patent/SI0871656T1/xx unknown
- 1996-06-03 IL IL12221696A patent/IL122216A/en not_active IP Right Cessation
- 1996-06-03 CN CNB961944684A patent/CN1182153C/zh not_active Expired - Fee Related
- 1996-06-03 UA UA98010069A patent/UA46775C2/uk unknown
- 1996-06-03 MX MX9709146A patent/MX9709146A/es unknown
- 1996-06-03 BR BR9609424-9A patent/BR9609424A/pt not_active Application Discontinuation
- 1996-06-04 MY MYPI96002170A patent/MY124487A/en unknown
- 1996-06-06 ZA ZA9604710A patent/ZA964710B/xx unknown
- 1996-06-06 HR HR08/472,453A patent/HRP960257A2/hr not_active Application Discontinuation
- 1996-06-06 AR ARP960102981A patent/AR003427A1/es active IP Right Grant
- 1996-06-06 HR HR08/472,453A patent/HRP960277A2/hr not_active Application Discontinuation
- 1996-06-06 AR ARP960102980A patent/AR003136A1/es active IP Right Grant
- 1996-06-06 ZA ZA9604711A patent/ZA964711B/xx unknown
- 1996-06-07 TW TW085106866A patent/TW508357B/zh not_active IP Right Cessation
- 1996-06-07 CO CO96029751A patent/CO4700527A1/es unknown
- 1996-06-07 CO CO96029749A patent/CO4700526A1/es unknown
- 1996-10-02 TW TW085106867A patent/TW424096B/zh not_active IP Right Cessation
-
1997
- 1997-12-05 NO NO19975710A patent/NO318384B1/no not_active IP Right Cessation
- 1997-12-05 NO NO19975711A patent/NO317670B1/no not_active IP Right Cessation
- 1997-12-18 BG BG102125A patent/BG102125A/xx unknown
- 1997-12-29 BG BG102152A patent/BG102152A/xx unknown
Also Published As
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| AU679479B2 (en) | Dolostatin analog | |
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| IL166853A (en) | Antineoplastic peptides, their preparation and various uses thereof | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: ABBVIE DEUTSCHLAND GMBH & CO AG, DE |
|
| MM1K | Lapsed by not paying the annual fees |