NO317242B1 - Heterocykluser som inhibitorer av leukosyttadhesjon og VLA-4-antagonister - Google Patents
Heterocykluser som inhibitorer av leukosyttadhesjon og VLA-4-antagonister Download PDFInfo
- Publication number
- NO317242B1 NO317242B1 NO19975245A NO975245A NO317242B1 NO 317242 B1 NO317242 B1 NO 317242B1 NO 19975245 A NO19975245 A NO 19975245A NO 975245 A NO975245 A NO 975245A NO 317242 B1 NO317242 B1 NO 317242B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- aryl
- residue
- stands
- optionally substituted
- Prior art date
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- QTRZIXGEEDEWOL-ZBUUCQELSA-N tert-butyl (2s)-2-[1-adamantyl(methoxycarbonyl)amino]-3-aminopropanoate Chemical compound C1C(C2)CC3CC2CC1(N([C@@H](CN)C(=O)OC(C)(C)C)C(=O)OC)C3 QTRZIXGEEDEWOL-ZBUUCQELSA-N 0.000 description 1
- RMMATBBIKAKDDP-QRPNPIFTSA-N tert-butyl (2s)-2-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)NC[C@H](N)C(=O)OC(C)(C)C RMMATBBIKAKDDP-QRPNPIFTSA-N 0.000 description 1
- LJOXZTPVWYQXEC-UHFFFAOYSA-N tert-butyl 2-(butoxycarbonylamino)propanoate Chemical compound C(C)(C)(C)OC(C(C)NC(=O)OCCCC)=O LJOXZTPVWYQXEC-UHFFFAOYSA-N 0.000 description 1
- UQJXXWHAJKRDKY-UHFFFAOYSA-N tert-butyl n-[[(2-methylpropan-2-yl)oxycarbonylamino]-methylsulfanylmethylidene]carbamate Chemical compound CC(C)(C)OC(=O)NC(SC)=NC(=O)OC(C)(C)C UQJXXWHAJKRDKY-UHFFFAOYSA-N 0.000 description 1
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- 125000002469 tricosyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- PCFIPYFVXDCWBW-UHFFFAOYSA-N tricyclo[3.3.1.03,7]nonane Chemical compound C1C(C2)C3CC2CC1C3 PCFIPYFVXDCWBW-UHFFFAOYSA-N 0.000 description 1
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 230000007306 turnover Effects 0.000 description 1
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- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Tropical Medicine & Parasitology (AREA)
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- Hematology (AREA)
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- Crystallography & Structural Chemistry (AREA)
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- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19647382A DE19647382A1 (de) | 1996-11-15 | 1996-11-15 | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO975245D0 NO975245D0 (no) | 1997-11-14 |
| NO975245L NO975245L (no) | 1998-05-18 |
| NO317242B1 true NO317242B1 (no) | 2004-09-27 |
Family
ID=7811832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19975245A NO317242B1 (no) | 1996-11-15 | 1997-11-14 | Heterocykluser som inhibitorer av leukosyttadhesjon og VLA-4-antagonister |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5998447A (es) |
| EP (1) | EP0842944B1 (es) |
| JP (1) | JP4510160B2 (es) |
| CN (1) | CN1133647C (es) |
| AR (1) | AR010066A1 (es) |
| AT (1) | ATE244725T1 (es) |
| AU (1) | AU736595B2 (es) |
| BR (1) | BR9705726A (es) |
| CA (1) | CA2220822A1 (es) |
| CZ (1) | CZ292521B6 (es) |
| DE (2) | DE19647382A1 (es) |
| DK (1) | DK0842944T3 (es) |
| ES (1) | ES2202533T3 (es) |
| HR (1) | HRP970606B1 (es) |
| HU (1) | HUP9702034A3 (es) |
| IL (1) | IL122186A (es) |
| MX (1) | MX9708781A (es) |
| MY (1) | MY118176A (es) |
| NO (1) | NO317242B1 (es) |
| NZ (1) | NZ329177A (es) |
| PL (2) | PL323130A1 (es) |
| PT (1) | PT842944E (es) |
| RU (1) | RU2220977C2 (es) |
| SI (1) | SI0842944T1 (es) |
| SK (1) | SK284349B6 (es) |
| TR (1) | TR199701356A2 (es) |
| TW (1) | TW580501B (es) |
| ZA (1) | ZA9710245B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19647381A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647382A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
| DE19821483A1 (de) * | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| NZ509241A (en) | 1998-08-07 | 2003-08-29 | Du Pont Pharm Co | Succinoylamino lactams as inhibitors of alpha-beta protein production |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| AU778005B2 (en) | 1998-12-24 | 2004-11-11 | Bristol-Myers Squibb Pharma Company | Succinoylamino benzodiazepines as inhibitors of Abeta protein production |
| DE19922462A1 (de) * | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| WO2001027091A1 (en) | 1999-10-08 | 2001-04-19 | Du Pont Pharmaceuticals Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| EP1244656A1 (en) | 1999-12-28 | 2002-10-02 | Pfizer Products Inc. | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
| AU2882801A (en) * | 2000-01-28 | 2001-08-07 | Kaken Pharmaceutical Co., Ltd. | Azepine derivatives |
| JP2003523345A (ja) | 2000-02-17 | 2003-08-05 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環 |
| US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
| JP2004508289A (ja) | 2000-04-03 | 2004-03-18 | デュポン ファーマシューティカルズ カンパニー | Ａβタンパク質産生の阻害剤としての環状ラクタム |
| EP1268433A1 (en) | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of a-beta-protein production |
| JP2004500419A (ja) | 2000-04-11 | 2004-01-08 | デュポン ファーマシューティカルズ カンパニー | Ａβタンパク質産生阻害剤としての置換ラクタム |
| NZ516746A (en) | 2000-06-01 | 2004-02-27 | Bristol Myers Squibb Pharma | Lactams substituted by cyclic succinates as inhibitors of A-beta protein production |
| JP2004516237A (ja) * | 2000-06-21 | 2004-06-03 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | ケモカイン受容体活性調節剤としてのピペリジンアミド類 |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10137595A1 (de) * | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
| TW200307667A (en) * | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
| US7630761B2 (en) * | 2005-11-04 | 2009-12-08 | Cardiac Pacemakers, Inc. | Method and apparatus for modifying tissue to improve electrical stimulation efficacy |
| CA2714335A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| AU2009234253C1 (en) | 2008-04-11 | 2015-05-07 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| WO2009131957A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
| US8236838B2 (en) * | 2008-04-21 | 2012-08-07 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
| WO2009131947A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyridazine derivatives |
| US20090264433A1 (en) * | 2008-04-21 | 2009-10-22 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Triazine Derivatives |
| US8759384B2 (en) * | 2008-05-12 | 2014-06-24 | David J. Bearss | Oxo-imidazolyl compounds |
| JP2012503005A (ja) * | 2008-09-19 | 2012-02-02 | インスティテュート フォア ワンワールド ヘルス | イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。 |
| DE102009012314A1 (de) | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
| US8511216B2 (en) * | 2009-03-30 | 2013-08-20 | Kanzaki Kokyukoki Mfg. Co., Ltd. | Hydraulic actuator unit |
| US8343976B2 (en) * | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
| US20120258093A1 (en) | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
| CA2816016A1 (en) | 2010-10-25 | 2012-05-10 | Elan Pharmaceuticals, Inc. | Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US20240301512A1 (en) | 2021-01-29 | 2024-09-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993013798A1 (en) * | 1992-01-13 | 1993-07-22 | Biogen, Inc. | Treatment for asthma |
| DE4224414A1 (de) * | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
| EP0677060A1 (en) * | 1993-01-08 | 1995-10-18 | Tanabe Seiyaku Co., Ltd. | Peptide inhibitors of cell adhesion |
| DE4427979A1 (de) * | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
| WO1995015973A1 (en) * | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| EP0767674A4 (en) * | 1994-06-29 | 1999-06-16 | Texas Biotechnology Corp | METHOD FOR INHIBITING THE BINDING OF INTEGRIN ALPHA 4 BETA 1 TO VCAM-1 OR FIBRONECTIN |
| US5811391A (en) * | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| GB9524630D0 (en) * | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| DK0796855T3 (da) * | 1996-03-20 | 2002-05-27 | Hoechst Ag | Hæmmere af knogleresorption og vitronectin-receptorantagonister |
| DE19647382A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
-
1996
- 1996-11-15 DE DE19647382A patent/DE19647382A1/de not_active Withdrawn
- 1996-11-15 PL PL96323130A patent/PL323130A1/xx unknown
-
1997
- 1997-11-10 EP EP97119639A patent/EP0842944B1/de not_active Expired - Lifetime
- 1997-11-10 DK DK97119639T patent/DK0842944T3/da active
- 1997-11-10 DE DE59710411T patent/DE59710411D1/de not_active Expired - Lifetime
- 1997-11-10 ES ES97119639T patent/ES2202533T3/es not_active Expired - Lifetime
- 1997-11-10 AT AT97119639T patent/ATE244725T1/de not_active IP Right Cessation
- 1997-11-10 SI SI9730578T patent/SI0842944T1/xx unknown
- 1997-11-10 PT PT97119639T patent/PT842944E/pt unknown
- 1997-11-12 CA CA002220822A patent/CA2220822A1/en not_active Abandoned
- 1997-11-13 SK SK1525-97A patent/SK284349B6/sk unknown
- 1997-11-13 ZA ZA9710245A patent/ZA9710245B/xx unknown
- 1997-11-13 NZ NZ329177A patent/NZ329177A/en unknown
- 1997-11-13 RU RU97119628/04A patent/RU2220977C2/ru not_active IP Right Cessation
- 1997-11-13 TW TW086116878A patent/TW580501B/zh not_active IP Right Cessation
- 1997-11-13 IL IL12218697A patent/IL122186A/xx not_active IP Right Cessation
- 1997-11-13 HR HR970606A patent/HRP970606B1/xx not_active IP Right Cessation
- 1997-11-13 TR TR97/01356A patent/TR199701356A2/xx unknown
- 1997-11-13 MY MYPI97005417A patent/MY118176A/en unknown
- 1997-11-13 AU AU45257/97A patent/AU736595B2/en not_active Ceased
- 1997-11-13 AR ARP970105301A patent/AR010066A1/es unknown
- 1997-11-13 CZ CZ19973600A patent/CZ292521B6/cs not_active IP Right Cessation
- 1997-11-14 BR BR9705726A patent/BR9705726A/pt not_active Application Discontinuation
- 1997-11-14 CN CNB971226830A patent/CN1133647C/zh not_active Expired - Fee Related
- 1997-11-14 HU HU9702034A patent/HUP9702034A3/hu unknown
- 1997-11-14 NO NO19975245A patent/NO317242B1/no unknown
- 1997-11-14 MX MX9708781A patent/MX9708781A/es not_active IP Right Cessation
- 1997-11-14 JP JP32970197A patent/JP4510160B2/ja not_active Expired - Fee Related
- 1997-11-15 PL PL97323130A patent/PL188042B1/pl not_active IP Right Cessation
- 1997-11-17 US US08/972,031 patent/US5998447A/en not_active Expired - Lifetime
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1999
- 1999-09-27 US US09/405,843 patent/US6514952B1/en not_active Expired - Fee Related
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