AR010066A1 - Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4 - Google Patents
Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4Info
- Publication number
- AR010066A1 AR010066A1 ARP970105301A ARP970105301A AR010066A1 AR 010066 A1 AR010066 A1 AR 010066A1 AR P970105301 A ARP970105301 A AR P970105301A AR P970105301 A ARP970105301 A AR P970105301A AR 010066 A1 AR010066 A1 AR 010066A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- vla
- formula
- leukocytes
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Abstract
Compuestos de la formula (I), en la que B, D, E, R, W, Y, Z, b, c, d, e, f, g y h tienen los significados indicados en la reivindicaciones, son inhibidoresde la adhesion y migracion de leucocitos y/o antagonistas del receptor de adhesion VLA-4perteneciente al grupo de las integrinas. Se refiere al empleode compuestos de la formula (I) y de preparados farmacéuticos que contienen tales compuestos para el tratamiento o la profilaxis de enfermedades que sonprovocadas por un gradoindesead o de adhesion de leucocitos y/o migracion de leucocitos o que están ligadas a ellas, o en las que juegan un papelinteracciones célula-célula o célula-matrix, que se basan en interacciones de receptores VLA-4 con sus ligandos, porejemplo de proc esos inflamatorios, laartritis reumatoide o de enfermedades alérgicas, al igual que al empleo de compuestos de la formula (I) para la preparacion de medicamentos para empleo enenfermedades de este tipo. Además, se refiere anuevos compuestos de la formula (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19647382A DE19647382A1 (de) | 1996-11-15 | 1996-11-15 | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
AR010066A1 true AR010066A1 (es) | 2000-05-17 |
Family
ID=7811832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970105301A AR010066A1 (es) | 1996-11-15 | 1997-11-13 | Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4 |
Country Status (28)
Country | Link |
---|---|
US (2) | US5998447A (es) |
EP (1) | EP0842944B1 (es) |
JP (1) | JP4510160B2 (es) |
CN (1) | CN1133647C (es) |
AR (1) | AR010066A1 (es) |
AT (1) | ATE244725T1 (es) |
AU (1) | AU736595B2 (es) |
BR (1) | BR9705726A (es) |
CA (1) | CA2220822A1 (es) |
CZ (1) | CZ292521B6 (es) |
DE (2) | DE19647382A1 (es) |
DK (1) | DK0842944T3 (es) |
ES (1) | ES2202533T3 (es) |
HR (1) | HRP970606B1 (es) |
HU (1) | HUP9702034A3 (es) |
IL (1) | IL122186A (es) |
MX (1) | MX9708781A (es) |
MY (1) | MY118176A (es) |
NO (1) | NO317242B1 (es) |
NZ (1) | NZ329177A (es) |
PL (2) | PL323130A1 (es) |
PT (1) | PT842944E (es) |
RU (1) | RU2220977C2 (es) |
SI (1) | SI0842944T1 (es) |
SK (1) | SK284349B6 (es) |
TR (1) | TR199701356A3 (es) |
TW (1) | TW580501B (es) |
ZA (1) | ZA9710245B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL323130A1 (en) | 1996-11-15 | 1998-05-25 | Hoechst Ag | Application of heterocyclic compounds in production of a pharmaceutic agent, novel heterocyclic compounds and pharmaceutic agent as such |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19647381A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) * | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) * | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
JP4615727B2 (ja) | 1998-12-24 | 2011-01-19 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Aβタンパク質生成の阻害剤としてのスクシノイルアミノベンゾジアゼピン |
DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
CA2387493A1 (en) | 1999-10-08 | 2001-04-19 | Lorin Andrew Thompson | Amino lactam sulfonamides as inhibitors of a.beta. protein production |
CA2396087A1 (en) | 1999-12-28 | 2001-07-19 | Louis Stanley Chupak | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
AU2882801A (en) * | 2000-01-28 | 2001-08-07 | Kaken Pharmaceutical Co., Ltd. | Azepine derivatives |
EP1261610A2 (en) | 2000-02-17 | 2002-12-04 | Bristol-Myers Squibb Pharma Company | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production |
US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
CA2404023A1 (en) * | 2000-04-03 | 2001-10-11 | Richard E. Olson | Cyclic lactams as inhibitors of a.beta. protein production |
JP2004508289A (ja) | 2000-04-03 | 2004-03-18 | デュポン ファーマシューティカルズ カンパニー | Aβタンパク質産生の阻害剤としての環状ラクタム |
WO2001077086A1 (en) | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
IL147629A0 (en) | 2000-06-01 | 2002-08-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
US6638950B2 (en) | 2000-06-21 | 2003-10-28 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
US6710058B2 (en) * | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10137595A1 (de) * | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
TW200307667A (en) * | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
US7630761B2 (en) * | 2005-11-04 | 2009-12-08 | Cardiac Pacemakers, Inc. | Method and apparatus for modifying tissue to improve electrical stimulation efficacy |
US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
CA2721093A1 (en) | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
US20090264433A1 (en) * | 2008-04-21 | 2009-10-22 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Triazine Derivatives |
WO2009131947A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyridazine derivatives |
WO2009131951A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
US8207205B2 (en) | 2008-04-21 | 2012-06-26 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
WO2010033626A1 (en) * | 2008-09-19 | 2010-03-25 | Institute For Oneworld Health | Compounds, compositions and methods comprising imidazole and triazole derivatives |
US8759384B2 (en) * | 2008-05-12 | 2014-06-24 | David J. Bearss | Oxo-imidazolyl compounds |
DE102009012314A1 (de) | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
US8511216B2 (en) * | 2009-03-30 | 2013-08-20 | Kanzaki Kokyukoki Mfg. Co., Ltd. | Hydraulic actuator unit |
US8343976B2 (en) * | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
US20120258093A1 (en) | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
US20130337470A1 (en) | 2010-10-25 | 2013-12-19 | Biogen Idec Ma Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMadCAM LEVELS |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
WO2022162164A1 (en) | 2021-01-29 | 2022-08-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0626861T4 (da) * | 1992-01-13 | 2004-08-16 | Biogen Inc | Behandling af astma. |
DE4224414A1 (de) * | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
WO1994015958A2 (en) * | 1993-01-08 | 1994-07-21 | Tanabe Seiyaku Co., Ltd. | Peptide inhibitors of cell adhesion |
DE4427979A1 (de) * | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
AU693143B2 (en) * | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
CA2193828A1 (en) * | 1994-06-29 | 1996-01-11 | Timothy P. Kogan | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
US5811391A (en) * | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
GB9524630D0 (en) * | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
EP0796855B1 (de) * | 1996-03-20 | 2002-02-06 | Hoechst Aktiengesellschaft | Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
PL323130A1 (en) | 1996-11-15 | 1998-05-25 | Hoechst Ag | Application of heterocyclic compounds in production of a pharmaceutic agent, novel heterocyclic compounds and pharmaceutic agent as such |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
-
1996
- 1996-11-15 PL PL96323130A patent/PL323130A1/xx unknown
- 1996-11-15 DE DE19647382A patent/DE19647382A1/de not_active Withdrawn
-
1997
- 1997-11-10 SI SI9730578T patent/SI0842944T1/xx unknown
- 1997-11-10 DK DK97119639T patent/DK0842944T3/da active
- 1997-11-10 ES ES97119639T patent/ES2202533T3/es not_active Expired - Lifetime
- 1997-11-10 DE DE59710411T patent/DE59710411D1/de not_active Expired - Lifetime
- 1997-11-10 PT PT97119639T patent/PT842944E/pt unknown
- 1997-11-10 AT AT97119639T patent/ATE244725T1/de not_active IP Right Cessation
- 1997-11-10 EP EP97119639A patent/EP0842944B1/de not_active Expired - Lifetime
- 1997-11-12 CA CA002220822A patent/CA2220822A1/en not_active Abandoned
- 1997-11-13 RU RU97119628/04A patent/RU2220977C2/ru not_active IP Right Cessation
- 1997-11-13 TW TW086116878A patent/TW580501B/zh not_active IP Right Cessation
- 1997-11-13 SK SK1525-97A patent/SK284349B6/sk unknown
- 1997-11-13 AU AU45257/97A patent/AU736595B2/en not_active Ceased
- 1997-11-13 TR TR97/01356A patent/TR199701356A3/tr unknown
- 1997-11-13 MY MYPI97005417A patent/MY118176A/en unknown
- 1997-11-13 IL IL12218697A patent/IL122186A/xx not_active IP Right Cessation
- 1997-11-13 CZ CZ19973600A patent/CZ292521B6/cs not_active IP Right Cessation
- 1997-11-13 AR ARP970105301A patent/AR010066A1/es unknown
- 1997-11-13 NZ NZ329177A patent/NZ329177A/en unknown
- 1997-11-13 HR HR970606A patent/HRP970606B1/xx not_active IP Right Cessation
- 1997-11-13 ZA ZA9710245A patent/ZA9710245B/xx unknown
- 1997-11-14 BR BR9705726A patent/BR9705726A/pt not_active Application Discontinuation
- 1997-11-14 MX MX9708781A patent/MX9708781A/es not_active IP Right Cessation
- 1997-11-14 JP JP32970197A patent/JP4510160B2/ja not_active Expired - Fee Related
- 1997-11-14 NO NO19975245A patent/NO317242B1/no unknown
- 1997-11-14 HU HU9702034A patent/HUP9702034A3/hu unknown
- 1997-11-14 CN CNB971226830A patent/CN1133647C/zh not_active Expired - Fee Related
- 1997-11-15 PL PL97323130A patent/PL188042B1/pl not_active IP Right Cessation
- 1997-11-17 US US08/972,031 patent/US5998447A/en not_active Expired - Lifetime
-
1999
- 1999-09-27 US US09/405,843 patent/US6514952B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR010066A1 (es) | Heterociclos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4 | |
AR010067A1 (es) | Heterociclos de 5 anillos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4 | |
AR010065A1 (es) | COMPUESTOS HETEROCíCLICOS Y EL USO DE LOS MISMOS PARA LA PREPARACION DE FARMACOS UTILES COMO INHIBIDORES DE LA ADHESION DE LEUCOCITOS Y ANTAGONISTAS DE LA VLA-4 | |
DE59915127D1 (de) | Imidazolidinderivate, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate | |
AR049333A1 (es) | Azaindoles inhibidores de proteinquinasas rock y otras proteinas quinasas. composiciones farmaceuticas. | |
ECSP21004787A (es) | Inhibidores de inflamasoma nlrp3 | |
BRPI0512703A (pt) | composto ou um sal ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para o tratamento de uma condição ou doença inflamatória ou imune em um indivìduo e para a modulação da função cxcr3 | |
MY118313A (en) | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | |
PA8431301A1 (es) | Inhibidores de metaloproteinasas, composiciones farmaceuticas que los contienen y sus usos farmaceuticos y los metodos e intermedios utiles para su preparacion | |
UY25804A1 (es) | Derivados de 4-aroilpiperidina que son antagonistas de los receptores ccr-3 | |
CO5580771A2 (es) | Antagonistas ccr5 como agentes terapeuticos | |
EA200400816A1 (ru) | Замещенные аналоги хиназолин-4-иламина в качестве модуляторов капсаицина | |
AR019626A1 (es) | Antagonistas receptores y5 de neuropeptidos. | |
EA202091530A1 (ru) | Диазаиндольные соединения | |
DE60041763D1 (de) | Inhibitoren von c-jun n-terminal kinasen (jnk) | |
YU84791A (sh) | Biciklicni 1-aza-cikloalkalni | |
AR118826A1 (es) | Inhibidores de cinasas raf | |
AR048501A1 (es) | Compuesto de benzoazabicicloheptano dimerico, composicion farmaceutica que lo comprende y su uso para prepararla | |
ES2131533T3 (es) | Compuestos ciclicos utiles como inhibidores del complejo glicoproteico plaquetario iib/iiia. | |
MY121745A (en) | 2,4-substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them. | |
ES2132882T3 (es) | Compuestos de 1-aril-2-acilamino-etano y su uso como antagonistas de neuroquinina 1. | |
TR199801870A2 (xx) | Yeni 5-halka-heterosiklenler, bunlar�n �retimi, bunlar�n kullan�m�. | |
BRPI0417943A (pt) | antagonistas de receptor de crf e métodos relacionados para essa finalidade | |
AR003467A1 (es) | Guanidinas sustituidas del acido cinamico, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi comomedicamento que las contiene. | |
AR068381A1 (es) | Compuestos de quinolina apropiados para tratar trastornos que responden a la modulacion del receptor de serotonina 5-ht6 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |