AR003467A1 - Guanidinas sustituidas del acido cinamico, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi comomedicamento que las contiene. - Google Patents

Guanidinas sustituidas del acido cinamico, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi comomedicamento que las contiene.

Info

Publication number
AR003467A1
AR003467A1 ARP960103724A AR10372496A AR003467A1 AR 003467 A1 AR003467 A1 AR 003467A1 AR P960103724 A ARP960103724 A AR P960103724A AR 10372496 A AR10372496 A AR 10372496A AR 003467 A1 AR003467 A1 AR 003467A1
Authority
AR
Argentina
Prior art keywords
carbon atoms
medicinal product
substituted
alkylene
procedure
Prior art date
Application number
ARP960103724A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of AR003467A1 publication Critical patent/AR003467A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Guanidinas sustituidas del ácido cinámico, procedimiento para su preparación, su empleo como medicamento o agente de diagnóstico, así comomedicamento que las contiene. Se describen compuestos de la fórmula (I) en los cuales por lo menosu no de los sustituyentes R(1), R(2), R(3), R(4) y R(5) esun heterociclo que contiene nitrógeno. Constituyen excelentes agentes terapéuticos de la circulación del corazón. Se obtienen por reacción de uncompuesto (II), con guanidina, endonde: los sustituyentes R(1), R(2), R(3), R(4) y R(5) significa:-Xa-Yb-Ln-U;X significa CR(16)R(17), O, S ó NR(18);R(16),R(17) y R(18),independientemente uno de otro,significan H, alquilo con 1,2,3 ó 4 átomos de C o perfluoroalquilo con 1, 2, 3ó 4 át omos de C;a significa 0 ó 1;Y significa alquileno con 1, 2, 3, 4, 5, 6, 7 u 8 átomos de C, alquileno-T con 1, 2, 3, 4, 5, 6, 7 u 8 átomos de C en el grupo alquileno, T, T-alquileno con1, 2, 3, 4, 5, 6, 7 u 8 átomos de C en el grupoalquileno; T sign ifica NR(20), O, S o fenileno, no estando el fenileno sustituido o estando sustituido con 1-3sustituyentes elegidos del grupo que consta de F, Cl, CF3, metilo, metoxi y NR(21)R(22); R(20), R(21) y R(22), independientemente unode otro, significa nH, alquilo con 1, 2, 3, ó 4 átomos de C o perfluoroalquilo con 1, 2, 3, ó 4 átomos de C; b significa cero o 1; L significa O, S, NR(23) ó CkH2k; ksignifica 1, 2, 3, 4, 5, 6, 7, 8; n significa cero ó 1; U significa NR(24)R(25)o un heterociclo qu e contiene N con 1, 2, 3, 4, 5, 6, 7, 8 ó 9 átomos de C;R(24) y R(25), independientemente uno de otro, significan H, alquilo con 1, 2, 3, 4, 5, 6, 7 u 8 átomos de C o perfluoroalquilo con 1, 2, 3, 4, 5, 6, 7 u 8átomos de C; oR(24) y R(25) juntos si gnifican 4 ó 5 grupos metileno, de los cuales un grupo CH2 puede estar sustituido con O, S, NH, H-CH3 ó N-bencilo;
ARP960103724A 1995-07-26 1996-07-24 Guanidinas sustituidas del acido cinamico, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi comomedicamento que las contiene. AR003467A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19527305A DE19527305A1 (de) 1995-07-26 1995-07-26 Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
AR003467A1 true AR003467A1 (es) 1998-08-05

Family

ID=7767840

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103724A AR003467A1 (es) 1995-07-26 1996-07-24 Guanidinas sustituidas del acido cinamico, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi comomedicamento que las contiene.

Country Status (29)

Country Link
US (1) US5883133A (es)
EP (1) EP0755919B1 (es)
JP (1) JP4177466B2 (es)
KR (1) KR970006281A (es)
CN (1) CN1062554C (es)
AR (1) AR003467A1 (es)
AT (1) ATE186720T1 (es)
AU (1) AU704461B2 (es)
BR (1) BR9603179A (es)
CA (1) CA2182062C (es)
CZ (1) CZ289327B6 (es)
DE (2) DE19527305A1 (es)
DK (1) DK0755919T3 (es)
ES (1) ES2140765T3 (es)
GR (1) GR3032363T3 (es)
HR (1) HRP960356B1 (es)
HU (1) HUP9602072A3 (es)
IL (1) IL118925A (es)
MX (1) MX9603004A (es)
MY (1) MY115466A (es)
NO (1) NO306060B1 (es)
NZ (1) NZ299052A (es)
PL (1) PL183439B1 (es)
RU (1) RU2190601C2 (es)
SI (1) SI0755919T1 (es)
SK (1) SK282018B6 (es)
TR (1) TR199600612A2 (es)
TW (1) TW536531B (es)
ZA (1) ZA966313B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19527305A1 (de) * 1995-07-26 1997-01-30 Hoechst Ag Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US6110922A (en) 1998-12-29 2000-08-29 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US6878700B1 (en) 1998-12-29 2005-04-12 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
DE10024319A1 (de) * 2000-05-17 2001-11-22 Merck Patent Gmbh Bisacylguanidine
GB0015205D0 (en) * 2000-06-21 2000-08-09 Karobio Ab Bioisosteric thyroid receptor ligands and method
NZ523445A (en) * 2000-06-29 2004-10-29 Abbott Lab Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
DE10046993A1 (de) * 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
CN1615295B (zh) * 2001-11-29 2010-11-03 特拉科斯公司 用于炎症、糖尿病和相关病症治疗的化合物
DE10258168B4 (de) * 2002-12-12 2005-07-07 Infineon Technologies Ag Integrierter DRAM-Halbleiterspeicher und Verfahren zum Betrieb desselben
JP5030587B2 (ja) 2003-06-26 2012-09-19 バイオトロン・リミテッド 抗ウイルスアシルグアニジン化合物および方法
ES2491217T3 (es) 2005-06-24 2014-09-05 Biotron Limited Compuestos de acilguanidina antivirales
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734904A (en) * 1956-02-14 Xcxnhxc-nh
US4544670A (en) 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
CN1036267C (zh) * 1992-02-15 1997-10-29 赫彻斯特股份公司 氨基取代的苯甲酰胍的制备方法
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE4325822A1 (de) * 1993-07-31 1995-02-02 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19527305A1 (de) * 1995-07-26 1997-01-30 Hoechst Ag Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
MX9603004A (es) 1997-01-31
KR970006281A (ko) 1997-02-19
NO963108L (no) 1997-01-27
PL314279A1 (en) 1997-02-03
JP4177466B2 (ja) 2008-11-05
US5883133A (en) 1999-03-16
EP0755919B1 (de) 1999-11-17
RU2190601C2 (ru) 2002-10-10
SK282018B6 (sk) 2001-10-08
AU704461B2 (en) 1999-04-22
TR199600612A2 (tr) 1997-04-22
GR3032363T3 (en) 2000-04-27
NO963108D0 (no) 1996-07-25
AU6066896A (en) 1997-01-30
HRP960356A2 (en) 1998-02-28
HUP9602072A3 (en) 1997-10-28
NO306060B1 (no) 1999-09-13
HUP9602072A2 (en) 1997-05-28
EP0755919A2 (de) 1997-01-29
DE19527305A1 (de) 1997-01-30
CN1062554C (zh) 2001-02-28
CA2182062A1 (en) 1997-01-27
SI0755919T1 (en) 2000-04-30
ES2140765T3 (es) 2000-03-01
MY115466A (en) 2003-06-30
ZA966313B (en) 1997-02-11
IL118925A0 (en) 1996-10-31
JPH0952823A (ja) 1997-02-25
ATE186720T1 (de) 1999-12-15
CA2182062C (en) 2008-12-02
CN1145899A (zh) 1997-03-26
HRP960356B1 (en) 2001-02-28
IL118925A (en) 2001-08-08
NZ299052A (en) 1997-10-24
CZ218496A3 (en) 1997-02-12
TW536531B (en) 2003-06-11
HU9602072D0 (en) 1996-09-30
CZ289327B6 (cs) 2002-01-16
PL183439B1 (pl) 2002-06-28
DE59603659D1 (de) 1999-12-23
EP0755919A3 (de) 1997-04-09
BR9603179A (pt) 2002-04-09
DK0755919T3 (da) 2000-04-25
SK96596A3 (en) 1997-03-05

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