NO20093194L - Vektor for uttrykkelse av en sekvens som koder for et cytotoksisk genprodukt, og anvendelse av denne for a fremstille et medikament for behandling av cancer - Google Patents

Vektor for uttrykkelse av en sekvens som koder for et cytotoksisk genprodukt, og anvendelse av denne for a fremstille et medikament for behandling av cancer

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Publication number
NO20093194L
NO20093194L NO20093194A NO20093194A NO20093194L NO 20093194 L NO20093194 L NO 20093194L NO 20093194 A NO20093194 A NO 20093194A NO 20093194 A NO20093194 A NO 20093194A NO 20093194 L NO20093194 L NO 20093194L
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NO
Norway
Prior art keywords
cancer
treatment
expressing
drug
vector
Prior art date
Application number
NO20093194A
Other languages
English (en)
Other versions
NO331723B1 (no
Inventor
Abraham Hochberg
Suhail Ayesh
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20093194L publication Critical patent/NO20093194L/no
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Publication of NO331723B1 publication Critical patent/NO331723B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Oppfinnelsen vedrører spesifikk ekspresjon av heterologe sekvenser, spesielt gener som koder for cytotoksiske produkter, i tumorceller under kontroll av regulatoriske transkripsjonelle sekvenser. Spesielt foretrukket promotere inkluderer HI 9 regulatoriske sekvenser, IGF-1 promoter og IGF-2 P3 og P4 promotere. Oppfinnelsen tilveiebringer ekspresjonskonstruksjoner og metoder for administrering av slike ekspresjonskonstruksjoner. Sammensetningene og metodene fra oppfinnelsen er nyttige i behandling av cancer.
NO20093194A 1997-10-03 2009-10-22 Vektor som kan utrykke et cytotoksisk genprodukt samt anvendelse av en slik vektor for fremstilling av et preparat for behandling av kreft NO331723B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94360897A 1997-10-03 1997-10-03
PCT/IL1998/000486 WO1999018195A2 (en) 1997-10-03 1998-10-04 Methods and compositions for inducing tumor-specific cytotoxicity

Publications (2)

Publication Number Publication Date
NO20093194L true NO20093194L (no) 2000-06-02
NO331723B1 NO331723B1 (no) 2012-03-05

Family

ID=25479934

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20001684A NO328470B1 (no) 1997-10-03 2000-03-31 Vektor for a uttrykke en sekvens i en tumorcelle og vertcelle omfattende denne, samt fremgangsmater for a uttrykke sekvensen in vitro og anvendelse av vektoren for fremstilling av et medikament for behandling av cancer.
NO20093194A NO331723B1 (no) 1997-10-03 2009-10-22 Vektor som kan utrykke et cytotoksisk genprodukt samt anvendelse av en slik vektor for fremstilling av et preparat for behandling av kreft

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20001684A NO328470B1 (no) 1997-10-03 2000-03-31 Vektor for a uttrykke en sekvens i en tumorcelle og vertcelle omfattende denne, samt fremgangsmater for a uttrykke sekvensen in vitro og anvendelse av vektoren for fremstilling av et medikament for behandling av cancer.

Country Status (17)

Country Link
US (2) US6087164A (no)
EP (1) EP1019499B1 (no)
JP (3) JP5153031B2 (no)
KR (1) KR100524262B1 (no)
CN (1) CN1229496C (no)
AT (1) ATE407948T1 (no)
AU (1) AU755774B2 (no)
BR (1) BR9812717B1 (no)
CA (1) CA2308124C (no)
CZ (2) CZ294941B6 (no)
DE (1) DE69840001D1 (no)
HU (1) HU228470B1 (no)
IL (1) IL135430A0 (no)
NO (2) NO328470B1 (no)
PL (1) PL339949A1 (no)
RU (1) RU2214280C2 (no)
WO (1) WO1999018195A2 (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040006220A1 (en) * 2002-07-02 2004-01-08 Isis Pharmaceuticals Inc. Antisense modulation of insulin-like growth factor 2 expression
US7041654B2 (en) 1997-10-03 2006-05-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for inducing tumor-specific cytotoxicity
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
CA2365901A1 (en) * 1999-04-14 2000-10-19 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
DE19928342A1 (de) * 1999-06-21 2000-12-28 Deutsches Krebsforsch Vektoren zur gentherapeutischen Tumorbehandlung
US7829693B2 (en) * 1999-11-24 2010-11-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
WO2002046449A2 (en) * 2000-12-07 2002-06-13 The Penn State Research Foundation Selection of catalytic nucleic acids targeted to infectious agents
US8546143B2 (en) 2001-01-09 2013-10-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
US20040005567A1 (en) * 2002-07-02 2004-01-08 Isis Pharmaceuticals Inc. Antisense modulation of cyclin-dependent kinase 4 expression
AU2003241985A1 (en) * 2002-05-31 2003-12-19 Medinet Co., Ltd. Dna inducing cancer cell-specific expression and cancer cell-specific expression vector
US20040180844A1 (en) * 2003-03-10 2004-09-16 Fesik Stephen W. Method of killing cancer cells
US20040220085A1 (en) * 2003-05-02 2004-11-04 Jasbir Sandhu Compositions for nucleic acid delivery
US20040219099A1 (en) * 2003-05-02 2004-11-04 Jasbir Sandhu Method for the treatment of tumors
US7482156B2 (en) * 2003-10-15 2009-01-27 Cell Genesys, Inc. Hepatocellular carcinoma specific promoter and uses thereof
US7063947B2 (en) * 2004-04-08 2006-06-20 Promogen, Inc. System for producing synthetic promoters
US7429482B2 (en) * 2005-01-13 2008-09-30 United States Of America As Represented By The Department Of Veterans Affairs Screening tools for discovery of novel anabolic agents
EP1915448B1 (en) 2005-07-07 2013-09-04 Yissum Research Development Company, of The Hebrew University of Jerusalem Nucleic acid agents for downregulating h19, and methods of using same
DE602006014009D1 (de) 2005-09-22 2010-06-10 Yissum Res Dev Co Nukleinsäure konstrukten, pharmazeutische kompositionen und methoden für die behandlung von krebs
CA2675967A1 (en) * 2007-01-16 2008-07-24 Yissum Research Development Company Of The Hebrew University Of Jerusale M Nucleic acid constructs and methods for specific silencing of h19
CA2715080C (en) 2007-09-28 2021-09-28 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
WO2009053982A1 (en) * 2007-10-25 2009-04-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Constructs containing multiple expression cassettes for cancer therapy
EP2298866A4 (en) * 2008-07-02 2013-11-20 Otsuka Pharma Co Ltd ARTIFICIAL KIDNEY PRECURSOR AND METHOD FOR PRODUCING THE SAME
US8492133B2 (en) 2009-01-20 2013-07-23 Ramot At Tel Aviv University, Ltd. MIR-21 promoter driven targeted cancer therapy
EA016223B1 (ru) * 2009-10-07 2012-03-30 Учреждение Российской Академии Наук Институт Молекулярной Генетики Ран Способ и генная конструкция для высокоспецифичного ингибирования нежелательного роста клеток
WO2016178233A1 (en) * 2015-05-05 2016-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nucleic acid-cationic polymer compositions and methods of making and using the same
BR112020021962A2 (pt) * 2018-04-30 2021-01-26 Amicus Therapeutics, Inc. construtos para terapia gênica e métodos de uso
CN110714075B (zh) * 2018-07-13 2024-05-03 立森印迹诊断技术（无锡）有限公司 一种用于检测肺肿瘤良恶性程度的分级模型及其应用
CN111206093A (zh) * 2018-11-21 2020-05-29 立森印迹诊断技术（无锡）有限公司 一种用于检测浸润性膀胱癌的标志物及其应用
CN109609505A (zh) * 2019-01-14 2019-04-12 中国科学院成都生物研究所 一种体内筛选的剪切rna的锤头状核酶

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2699191B1 (fr) * 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
IL108879A (en) * 1994-03-07 2000-08-31 Yissum Res Dev Co Diagnostic assay for malignancies using the H19 gene and kit
FR2723697B1 (fr) * 1994-08-17 1996-09-20 Rhone Poulenc Rorer Sa Methode de traitement de la restenose par la therapie genique
FR2725213B1 (fr) * 1994-10-04 1996-11-08 Rhone Poulenc Rorer Sa Vecteurs viraux et utilisation en therapie genique

Also Published As

Publication number Publication date
WO1999018195A3 (en) 1999-08-12
AU755774B2 (en) 2002-12-19
EP1019499A2 (en) 2000-07-19
BR9812717A (pt) 2000-08-22
DE69840001D1 (de) 2008-10-23
CA2308124A1 (en) 1999-04-15
WO1999018195A2 (en) 1999-04-15
ATE407948T1 (de) 2008-09-15
JP2001519148A (ja) 2001-10-23
IL135430A0 (en) 2001-05-20
HUP0003745A2 (hu) 2001-02-28
CZ294941B6 (cs) 2005-04-13
CZ20001201A3 (cs) 2000-09-13
BR9812717B1 (pt) 2011-06-28
NO328470B1 (no) 2010-02-22
JP2008136480A (ja) 2008-06-19
JP5153031B2 (ja) 2013-02-27
RU2214280C2 (ru) 2003-10-20
JP2006304801A (ja) 2006-11-09
HUP0003745A3 (en) 2002-04-29
CZ294694B6 (cs) 2005-02-16
KR100524262B1 (ko) 2005-10-28
NO20001684L (no) 2000-06-02
HU228470B1 (en) 2013-03-28
NO331723B1 (no) 2012-03-05
AU9457198A (en) 1999-04-27
CN1229496C (zh) 2005-11-30
EP1019499B1 (en) 2008-09-10
US6306833B1 (en) 2001-10-23
CN1280616A (zh) 2001-01-17
US6087164A (en) 2000-07-11
CA2308124C (en) 2008-07-08
KR20010030912A (ko) 2001-04-16
PL339949A1 (en) 2001-01-15
NO20001684D0 (no) 2000-03-31

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