IL135430A0 - Method and compositions for inducing tumor specific cytotoxicity - Google Patents
Method and compositions for inducing tumor specific cytotoxicityInfo
- Publication number
- IL135430A0 IL135430A0 IL13543098A IL13543098A IL135430A0 IL 135430 A0 IL135430 A0 IL 135430A0 IL 13543098 A IL13543098 A IL 13543098A IL 13543098 A IL13543098 A IL 13543098A IL 135430 A0 IL135430 A0 IL 135430A0
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- tumor specific
- specific cytotoxicity
- inducing tumor
- sequences
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000003013 cytotoxicity Effects 0.000 title 1
- 231100000135 cytotoxicity Toxicity 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 abstract 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of regulatory transcriptional sequences. Particularly preferred promoters include H19 regulatory sequences, the IGF-1 promoter and the IGF-2 P3 and P4 promoters. The invention provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful in the treatment of cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94360897A | 1997-10-03 | 1997-10-03 | |
PCT/IL1998/000486 WO1999018195A2 (en) | 1997-10-03 | 1998-10-04 | Methods and compositions for inducing tumor-specific cytotoxicity |
Publications (1)
Publication Number | Publication Date |
---|---|
IL135430A0 true IL135430A0 (en) | 2001-05-20 |
Family
ID=25479934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13543098A IL135430A0 (en) | 1997-10-03 | 1998-10-04 | Method and compositions for inducing tumor specific cytotoxicity |
Country Status (17)
Country | Link |
---|---|
US (2) | US6087164A (en) |
EP (1) | EP1019499B1 (en) |
JP (3) | JP5153031B2 (en) |
KR (1) | KR100524262B1 (en) |
CN (1) | CN1229496C (en) |
AT (1) | ATE407948T1 (en) |
AU (1) | AU755774B2 (en) |
BR (1) | BR9812717B1 (en) |
CA (1) | CA2308124C (en) |
CZ (2) | CZ294941B6 (en) |
DE (1) | DE69840001D1 (en) |
HU (1) | HU228470B1 (en) |
IL (1) | IL135430A0 (en) |
NO (2) | NO328470B1 (en) |
PL (1) | PL339949A1 (en) |
RU (1) | RU2214280C2 (en) |
WO (1) | WO1999018195A2 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040006220A1 (en) * | 2002-07-02 | 2004-01-08 | Isis Pharmaceuticals Inc. | Antisense modulation of insulin-like growth factor 2 expression |
US7041654B2 (en) * | 1997-10-03 | 2006-05-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for inducing tumor-specific cytotoxicity |
DE19956568A1 (en) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Method and medicament for inhibiting the expression of a given gene |
AU778737B2 (en) * | 1999-04-14 | 2004-12-16 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
DE19928342A1 (en) * | 1999-06-21 | 2000-12-28 | Deutsches Krebsforsch | New vector for tissue-specific expression, useful for treating tumors, contains gene for e.g. a cytotoxin under control of tissue-specific promoter and enhancer |
US7829693B2 (en) * | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
WO2002046449A2 (en) * | 2000-12-07 | 2002-06-13 | The Penn State Research Foundation | Selection of catalytic nucleic acids targeted to infectious agents |
US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
US20040005567A1 (en) * | 2002-07-02 | 2004-01-08 | Isis Pharmaceuticals Inc. | Antisense modulation of cyclin-dependent kinase 4 expression |
JPWO2003102186A1 (en) * | 2002-05-31 | 2005-09-29 | 株式会社メディネット | Cancer cell-specific expression-inducing DNA and cancer cell-specific expression vector |
US20040180844A1 (en) * | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
US20040219099A1 (en) * | 2003-05-02 | 2004-11-04 | Jasbir Sandhu | Method for the treatment of tumors |
US20040220085A1 (en) * | 2003-05-02 | 2004-11-04 | Jasbir Sandhu | Compositions for nucleic acid delivery |
US7482156B2 (en) * | 2003-10-15 | 2009-01-27 | Cell Genesys, Inc. | Hepatocellular carcinoma specific promoter and uses thereof |
US7063947B2 (en) * | 2004-04-08 | 2006-06-20 | Promogen, Inc. | System for producing synthetic promoters |
US7429482B2 (en) * | 2005-01-13 | 2008-09-30 | United States Of America As Represented By The Department Of Veterans Affairs | Screening tools for discovery of novel anabolic agents |
ES2435774T3 (en) | 2005-07-07 | 2013-12-23 | Yissum Research Development Company, Of The Hebrew University Of Jerusalem | Nucleic acid agents for the negative regulation of H19, and methods of use thereof |
US8034914B2 (en) | 2005-09-22 | 2011-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer |
US7928083B2 (en) * | 2007-01-16 | 2011-04-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | H19 silencing nucleic acid agents for treating rheumatoid arthritis |
WO2009045370A2 (en) | 2007-09-28 | 2009-04-09 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
CA2703774C (en) * | 2007-10-25 | 2019-05-21 | Avraham Hochberg | Constructs containing multiple expression cassettes for cancer therapy |
KR20110043580A (en) | 2008-07-02 | 2011-04-27 | 가부시키가이샤 오츠까 세이야꾸 고죠 | Artificial kidney precursor and process for production thereof |
US8492133B2 (en) | 2009-01-20 | 2013-07-23 | Ramot At Tel Aviv University, Ltd. | MIR-21 promoter driven targeted cancer therapy |
EA016223B1 (en) * | 2009-10-07 | 2012-03-30 | Учреждение Российской Академии Наук Институт Молекулярной Генетики Ран | Method and gene structure for high specific inhibiting of unwanted cell growth |
CA2984879A1 (en) * | 2015-05-05 | 2016-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Nucleic acid-cationic polymer compositions and methods of making and using the same |
TWI808169B (en) * | 2018-04-30 | 2023-07-11 | 美商阿米庫斯醫療股份有限公司 | Gene therapy constructs and methods of use |
CN110714075B (en) * | 2018-07-13 | 2024-05-03 | 立森印迹诊断技术(无锡)有限公司 | Grading model for detecting benign and malignant degrees of lung tumor and application thereof |
CN111206093A (en) * | 2018-11-21 | 2020-05-29 | 立森印迹诊断技术(无锡)有限公司 | Marker for detecting invasive bladder cancer and application thereof |
CN109609505A (en) * | 2019-01-14 | 2019-04-12 | 中国科学院成都生物研究所 | A kind of hammerhead ribozyme of the shearing RNA screened in vivo |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2699191B1 (en) * | 1992-12-16 | 1995-02-10 | Univ Paris Curie | New retroviral vectors, cell lines containing them, and their use in the treatment of tumors. |
US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
IL108879A (en) * | 1994-03-07 | 2000-08-31 | Yissum Res Dev Co | Diagnostic assay for malignancies using the H19 gene and kit |
FR2723697B1 (en) * | 1994-08-17 | 1996-09-20 | Rhone Poulenc Rorer Sa | METHOD OF TREATING RESTENOSIS WITH GENE THERAPY |
FR2725213B1 (en) * | 1994-10-04 | 1996-11-08 | Rhone Poulenc Rorer Sa | VIRAL VECTORS AND USE IN GENE THERAPY |
-
1998
- 1998-10-01 US US09/165,240 patent/US6087164A/en not_active Expired - Lifetime
- 1998-10-04 IL IL13543098A patent/IL135430A0/en active IP Right Grant
- 1998-10-04 DE DE69840001T patent/DE69840001D1/en not_active Expired - Lifetime
- 1998-10-04 BR BRPI9812717-9A patent/BR9812717B1/en not_active IP Right Cessation
- 1998-10-04 CN CNB988118335A patent/CN1229496C/en not_active Expired - Lifetime
- 1998-10-04 HU HU0003745A patent/HU228470B1/en unknown
- 1998-10-04 WO PCT/IL1998/000486 patent/WO1999018195A2/en active IP Right Grant
- 1998-10-04 CZ CZ2004741A patent/CZ294941B6/en not_active IP Right Cessation
- 1998-10-04 JP JP2000514993A patent/JP5153031B2/en not_active Expired - Lifetime
- 1998-10-04 CA CA002308124A patent/CA2308124C/en not_active Expired - Lifetime
- 1998-10-04 CZ CZ20001201A patent/CZ294694B6/en not_active IP Right Cessation
- 1998-10-04 AT AT98947759T patent/ATE407948T1/en not_active IP Right Cessation
- 1998-10-04 EP EP98947759A patent/EP1019499B1/en not_active Expired - Lifetime
- 1998-10-04 KR KR10-2000-7003609A patent/KR100524262B1/en not_active IP Right Cessation
- 1998-10-04 RU RU2000111553/14A patent/RU2214280C2/en active
- 1998-10-04 AU AU94571/98A patent/AU755774B2/en not_active Expired
- 1998-10-04 PL PL98339949A patent/PL339949A1/en unknown
-
2000
- 2000-03-31 NO NO20001684A patent/NO328470B1/en not_active IP Right Cessation
- 2000-05-10 US US09/568,059 patent/US6306833B1/en not_active Expired - Lifetime
-
2006
- 2006-05-24 JP JP2006144648A patent/JP2006304801A/en not_active Withdrawn
-
2007
- 2007-10-18 JP JP2007270777A patent/JP2008136480A/en active Pending
-
2009
- 2009-10-22 NO NO20093194A patent/NO331723B1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed |