YU66200A - Humani bmp-4 promotor i postupak za istraživanje supstance koja je vezana sa kostima pomoću primene istog - Google Patents
Humani bmp-4 promotor i postupak za istraživanje supstance koja je vezana sa kostima pomoću primene istogInfo
- Publication number
- YU66200A YU66200A YU66200A YU66200A YU66200A YU 66200 A YU66200 A YU 66200A YU 66200 A YU66200 A YU 66200A YU 66200 A YU66200 A YU 66200A YU 66200 A YU66200 A YU 66200A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- human bmp
- promoter
- bone
- same
- activity
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000000988 bone and bone Anatomy 0.000 title abstract 2
- 101150067309 bmp4 gene Proteins 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 abstract 3
- 102000046148 human BMP4 Human genes 0.000 abstract 3
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 150000003384 small molecules Chemical class 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 108700008625 Reporter Genes Proteins 0.000 abstract 1
- 208000015100 cartilage disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001002 morphogenetic effect Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000011144 upstream manufacturing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Predmetni pronalazak obezbedjuje postupak za istraživanje jedinjenja male molekulske mase koja regulišu pozitivno ili negativno ekspresiju humanog BMP-4 sa osvrtom na receptorsku aktivnost pomoću korišćenja 5' gornjeg region gena koji sadrži humani BMP-4 promotor i animalnu ćeliju koja je uvedena sa rekombinantnim ekspresionim vektorom koji je vezan na odgovarajući reporterski gen. Jedinjenja niske molekulske mase i njihovi derivati koji su dobijeni pomoću predmetnog postupka imaju morfogenetsku aktivnost i inhibirajuću aktivnost za kost i hrskavicu preko ekspresije humanog BMP-4 i primenljiva su kao preventivni ili terapeutski agensi za hrskavicu i koštana obolenja.[The present invention provides a method for exploring low molecular weight compounds which regulate positively or negatively the expression of human BMP-4 with reference to a reporter activity by using 5' upstream region gene containing the human BMP-4 promoter and an anirnal cell introduced with a recombinant expression vector that has been connected to an appropriate reporter gene. The low molecular weight compounds and their derivatives obtained by the present method have morphogenetic activity and inhibiting activity for bone and cartilage through the expression of human BMP-4 and are useful as preventive or therapeutic agents for cartilage and bone diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10120173A JPH11313674A (ja) | 1998-04-30 | 1998-04-30 | ヒトｂｍｐ−４プロモーターおよびこれを用いた骨関連物質の探索法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU66200A true YU66200A (sh) | 2003-10-31 |
Family
ID=14779737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU66200A YU66200A (sh) | 1998-04-30 | 1999-04-22 | Humani bmp-4 promotor i postupak za istraživanje supstance koja je vezana sa kostima pomoću primene istog |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6458944B1 (sh) |
| EP (1) | EP1076664A2 (sh) |
| JP (1) | JPH11313674A (sh) |
| KR (1) | KR20010043135A (sh) |
| CN (1) | CN1307587A (sh) |
| AP (1) | AP2000001974A0 (sh) |
| AU (1) | AU759569B2 (sh) |
| BG (1) | BG104884A (sh) |
| BR (1) | BR9910086A (sh) |
| CA (1) | CA2326956A1 (sh) |
| EA (1) | EA200001131A1 (sh) |
| EE (1) | EE200000631A (sh) |
| HR (1) | HRP20000735A2 (sh) |
| HU (1) | HUP0102336A2 (sh) |
| ID (1) | ID26413A (sh) |
| IL (1) | IL139101A0 (sh) |
| NO (1) | NO20005432L (sh) |
| NZ (1) | NZ507622A (sh) |
| PL (1) | PL344526A1 (sh) |
| SK (1) | SK15992000A3 (sh) |
| TR (1) | TR200003165T2 (sh) |
| WO (1) | WO1999057145A2 (sh) |
| YU (1) | YU66200A (sh) |
| ZA (1) | ZA200006079B (sh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002034113A2 (en) * | 2000-10-24 | 2002-05-02 | Sdgi Holdings, Inc. | Methods and instruments for treating pseudoarthrosis |
| US7427677B2 (en) * | 2003-07-01 | 2008-09-23 | Academia Sinica | Expression of zebrafish bone morphogenetic protein 4 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083690A (en) | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
| AU5558498A (en) * | 1996-11-22 | 1998-06-22 | Akzo Nobel N.V. | Bmp-4 promoter and use thereof in screening of therapeutic agents for the prevention and/or treatment of osteoporosis |
-
1998
- 1998-04-30 JP JP10120173A patent/JPH11313674A/ja active Pending
-
1999
- 1999-04-22 CN CN99807956A patent/CN1307587A/zh active Pending
- 1999-04-22 TR TR2000/03165T patent/TR200003165T2/xx unknown
- 1999-04-22 KR KR1020007012029A patent/KR20010043135A/ko not_active Application Discontinuation
- 1999-04-22 EP EP99913527A patent/EP1076664A2/en not_active Withdrawn
- 1999-04-22 HU HU0102336A patent/HUP0102336A2/hu unknown
- 1999-04-22 BR BR9910086-0A patent/BR9910086A/pt not_active IP Right Cessation
- 1999-04-22 AP APAP/P/2000/001974A patent/AP2000001974A0/en unknown
- 1999-04-22 US US09/674,460 patent/US6458944B1/en not_active Expired - Fee Related
- 1999-04-22 CA CA002326956A patent/CA2326956A1/en not_active Abandoned
- 1999-04-22 SK SK1599-2000A patent/SK15992000A3/sk unknown
- 1999-04-22 NZ NZ507622A patent/NZ507622A/xx unknown
- 1999-04-22 WO PCT/IB1999/000732 patent/WO1999057145A2/en not_active Application Discontinuation
- 1999-04-22 AU AU31633/99A patent/AU759569B2/en not_active Ceased
- 1999-04-22 EA EA200001131A patent/EA200001131A1/ru unknown
- 1999-04-22 EE EEP200000631A patent/EE200000631A/xx unknown
- 1999-04-22 PL PL99344526A patent/PL344526A1/xx not_active Application Discontinuation
- 1999-04-22 YU YU66200A patent/YU66200A/sh unknown
- 1999-04-22 IL IL13910199A patent/IL139101A0/xx unknown
- 1999-04-22 ID IDW20002197A patent/ID26413A/id unknown
-
2000
- 2000-10-24 BG BG104884A patent/BG104884A/xx unknown
- 2000-10-27 ZA ZA200006079A patent/ZA200006079B/en unknown
- 2000-10-27 NO NO20005432A patent/NO20005432L/no not_active Application Discontinuation
- 2000-10-30 HR HR20000735A patent/HRP20000735A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20005432D0 (no) | 2000-10-27 |
| NZ507622A (en) | 2003-03-28 |
| PL344526A1 (en) | 2001-11-05 |
| AU759569B2 (en) | 2003-04-17 |
| CA2326956A1 (en) | 1999-11-11 |
| CN1307587A (zh) | 2001-08-08 |
| WO1999057145A2 (en) | 1999-11-11 |
| HRP20000735A2 (en) | 2001-10-31 |
| EP1076664A2 (en) | 2001-02-21 |
| WO1999057145A3 (en) | 2000-01-20 |
| EE200000631A (et) | 2002-02-15 |
| US6458944B1 (en) | 2002-10-01 |
| BR9910086A (pt) | 2000-12-26 |
| KR20010043135A (ko) | 2001-05-25 |
| ZA200006079B (en) | 2001-10-29 |
| ID26413A (id) | 2000-12-21 |
| AP2000001974A0 (en) | 2000-12-31 |
| SK15992000A3 (sk) | 2001-05-10 |
| TR200003165T2 (tr) | 2001-03-21 |
| NO20005432L (no) | 2000-10-27 |
| HUP0102336A2 (hu) | 2001-10-28 |
| AU3163399A (en) | 1999-11-23 |
| IL139101A0 (en) | 2001-11-25 |
| JPH11313674A (ja) | 1999-11-16 |
| EA200001131A1 (ru) | 2001-06-25 |
| BG104884A (en) | 2001-05-31 |
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