ATE346151T1 - Monomeres mp52/gdf-5 mit knochenmorphogener aktivität, und dieses enthaltende arzneimittel, zur vorbeugung und behandlung von knochen- und knorpelerkrankungen - Google Patents
Monomeres mp52/gdf-5 mit knochenmorphogener aktivität, und dieses enthaltende arzneimittel, zur vorbeugung und behandlung von knochen- und knorpelerkrankungenInfo
- Publication number
- ATE346151T1 ATE346151T1 AT99917029T AT99917029T ATE346151T1 AT E346151 T1 ATE346151 T1 AT E346151T1 AT 99917029 T AT99917029 T AT 99917029T AT 99917029 T AT99917029 T AT 99917029T AT E346151 T1 ATE346151 T1 AT E346151T1
- Authority
- AT
- Austria
- Prior art keywords
- bone
- gdf
- monomeric
- prevention
- treatment
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title abstract 3
- 208000020084 Bone disease Diseases 0.000 title 1
- 102000012966 Growth Differentiation Factor 5 Human genes 0.000 title 1
- 108010090254 Growth Differentiation Factor 5 Proteins 0.000 title 1
- 101100472152 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) REL1 gene Proteins 0.000 title 1
- 208000015100 cartilage disease Diseases 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 230000000921 morphogenic effect Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000000178 monomer Substances 0.000 abstract 3
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 abstract 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 102000008300 Mutant Proteins Human genes 0.000 abstract 1
- 108010021466 Mutant Proteins Proteins 0.000 abstract 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001002 morphogenetic effect Effects 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 239000013636 protein dimer Substances 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10141379A JPH11335398A (ja) | 1998-05-22 | 1998-05-22 | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE346151T1 true ATE346151T1 (de) | 2006-12-15 |
Family
ID=15290635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99917029T ATE346151T1 (de) | 1998-05-22 | 1999-05-14 | Monomeres mp52/gdf-5 mit knochenmorphogener aktivität, und dieses enthaltende arzneimittel, zur vorbeugung und behandlung von knochen- und knorpelerkrankungen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7235241B2 (de) |
| EP (1) | EP1078054B1 (de) |
| JP (2) | JPH11335398A (de) |
| AT (1) | ATE346151T1 (de) |
| AU (1) | AU3530999A (de) |
| CY (1) | CY1105933T1 (de) |
| DE (1) | DE69934110T8 (de) |
| DK (1) | DK1078054T3 (de) |
| ES (1) | ES2272063T3 (de) |
| PT (1) | PT1078054E (de) |
| WO (1) | WO1999061611A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| EP1074620A1 (de) * | 1999-08-06 | 2001-02-07 | HyGene AG | Monomer Protein der TGF-beta Familie |
| JPH11335398A (ja) * | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
| JP2002306163A (ja) * | 2001-04-11 | 2002-10-22 | Chemo Sero Therapeut Res Inst | 大腸菌を宿主とする遺伝子組換えヒトトロンビンの調製方法 |
| FI116827B (fi) | 2001-08-24 | 2006-03-15 | Univ Zuerich | Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö |
| CA2562833A1 (en) * | 2004-04-27 | 2005-11-03 | Galapagos N.V. | Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts |
| US8188226B2 (en) | 2005-11-18 | 2012-05-29 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | High activity growth factor mutants |
| JP5602368B2 (ja) * | 2006-02-28 | 2014-10-08 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） | ネトリン−１活性を用いた抗癌化合物のスクリーニング |
| GB0604966D0 (en) * | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
| SI2121142T1 (sl) * | 2007-01-25 | 2012-12-31 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Uporaba GDF-5 za izboljšanje ali vzdrževanje videza kože |
| EP2019117A1 (de) * | 2007-07-27 | 2009-01-28 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein |
| US20130122066A1 (en) | 2010-07-30 | 2013-05-16 | Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Drug delivery devices and growth factor formulations for accelerated wound healing |
| CN102382187B (zh) * | 2011-05-03 | 2013-05-22 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Fbxl15蛋白片段及其编码基因和应用 |
| EP2537538A1 (de) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbierbarer Wundverband |
| EP2602264A1 (de) | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | GDF-5-Mutant zur Induzierung der Knorpelbildung |
| US11464888B2 (en) | 2017-06-12 | 2022-10-11 | Warsaw Orthopedic, Inc. | Moldable formulations containing an oxysterol in an acellular tissue matrix |
| CN114786707A (zh) | 2019-12-18 | 2022-07-22 | 默克专利股份公司 | Gdf-5突变体用于治疗疼痛和软骨破坏的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5158934A (en) * | 1989-09-01 | 1992-10-27 | Genentech, Inc. | Method of inducing bone growth using TGF-β |
| US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
| US5118667A (en) * | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
| DE69434651T2 (de) * | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| JPH0931098A (ja) * | 1995-07-24 | 1997-02-04 | Hoechst Japan Ltd | 新規なタンパク質ｈｍｗヒトｍｐ５２ |
| JPH11335398A (ja) * | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
-
1998
- 1998-05-22 JP JP10141379A patent/JPH11335398A/ja active Pending
-
1999
- 1999-05-14 ES ES99917029T patent/ES2272063T3/es not_active Expired - Lifetime
- 1999-05-14 AU AU35309/99A patent/AU3530999A/en not_active Abandoned
- 1999-05-14 EP EP99917029A patent/EP1078054B1/de not_active Expired - Lifetime
- 1999-05-14 DK DK99917029T patent/DK1078054T3/da active
- 1999-05-14 WO PCT/IB1999/000866 patent/WO1999061611A1/en not_active Ceased
- 1999-05-14 DE DE69934110T patent/DE69934110T8/de active Active
- 1999-05-14 AT AT99917029T patent/ATE346151T1/de active
- 1999-05-14 PT PT99917029T patent/PT1078054E/pt unknown
- 1999-05-14 JP JP2000550995A patent/JP4272357B2/ja not_active Expired - Fee Related
-
2004
- 2004-01-06 US US10/751,451 patent/US7235241B2/en not_active Expired - Fee Related
-
2007
- 2007-01-16 CY CY20071100064T patent/CY1105933T1/el unknown
- 2007-06-06 US US11/758,878 patent/US7638129B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11335398A (ja) | 1999-12-07 |
| US20060019886A1 (en) | 2006-01-26 |
| DE69934110D1 (de) | 2007-01-04 |
| CY1105933T1 (el) | 2011-04-06 |
| DE69934110T8 (de) | 2007-06-06 |
| EP1078054B1 (de) | 2006-11-22 |
| US7638129B2 (en) | 2009-12-29 |
| AU3530999A (en) | 1999-12-13 |
| JP4272357B2 (ja) | 2009-06-03 |
| ES2272063T3 (es) | 2007-04-16 |
| JP2002516098A (ja) | 2002-06-04 |
| DK1078054T3 (da) | 2007-03-12 |
| US20080318856A1 (en) | 2008-12-25 |
| PT1078054E (pt) | 2007-02-28 |
| WO1999061611A1 (en) | 1999-12-02 |
| EP1078054A1 (de) | 2001-02-28 |
| US7235241B2 (en) | 2007-06-26 |
| DE69934110T2 (de) | 2007-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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