DK1078054T3 - Monomer MP52/GDF-5 med knoglemorfogenetisk aktivitet og lægemiddel indeholdende samme til forebyggelse og behandling af brusk- og knoglesygdomme - Google Patents

Monomer MP52/GDF-5 med knoglemorfogenetisk aktivitet og lægemiddel indeholdende samme til forebyggelse og behandling af brusk- og knoglesygdomme

Info

Publication number
DK1078054T3
DK1078054T3 DK99917029T DK99917029T DK1078054T3 DK 1078054 T3 DK1078054 T3 DK 1078054T3 DK 99917029 T DK99917029 T DK 99917029T DK 99917029 T DK99917029 T DK 99917029T DK 1078054 T3 DK1078054 T3 DK 1078054T3
Authority
DK
Denmark
Prior art keywords
cartilage
bone
monomers
gdf
monomer
Prior art date
Application number
DK99917029T
Other languages
English (en)
Inventor
Shinji Kawai
Yoshifumi Muraki
Michio Kimura
Mieko Katsuura
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioph Biotech Entw Pharm Gmbh filed Critical Bioph Biotech Entw Pharm Gmbh
Application granted granted Critical
Publication of DK1078054T3 publication Critical patent/DK1078054T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DK99917029T 1998-05-22 1999-05-14 Monomer MP52/GDF-5 med knoglemorfogenetisk aktivitet og lægemiddel indeholdende samme til forebyggelse og behandling af brusk- og knoglesygdomme DK1078054T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10141379A JPH11335398A (ja) 1998-05-22 1998-05-22 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬
PCT/IB1999/000866 WO1999061611A1 (en) 1998-05-22 1999-05-14 Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone

Publications (1)

Publication Number Publication Date
DK1078054T3 true DK1078054T3 (da) 2007-03-12

Family

ID=15290635

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99917029T DK1078054T3 (da) 1998-05-22 1999-05-14 Monomer MP52/GDF-5 med knoglemorfogenetisk aktivitet og lægemiddel indeholdende samme til forebyggelse og behandling af brusk- og knoglesygdomme

Country Status (11)

Country Link
US (2) US7235241B2 (da)
EP (1) EP1078054B1 (da)
JP (2) JPH11335398A (da)
AT (1) ATE346151T1 (da)
AU (1) AU3530999A (da)
CY (1) CY1105933T1 (da)
DE (1) DE69934110T8 (da)
DK (1) DK1078054T3 (da)
ES (1) ES2272063T3 (da)
PT (1) PT1078054E (da)
WO (1) WO1999061611A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
EP1074620A1 (en) * 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
JPH11335398A (ja) * 1998-05-22 1999-12-07 Hoechst Marion Roussel Kk 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬
JP2002306163A (ja) * 2001-04-11 2002-10-22 Chemo Sero Therapeut Res Inst 大腸菌を宿主とする遺伝子組換えヒトトロンビンの調製方法
FI116827B (fi) 2001-08-24 2006-03-15 Univ Zuerich Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö
ES2427177T3 (es) * 2004-04-27 2013-10-29 Galapagos N.V. Métodos, agentes y ensayos de detección de compuestos para inducir diferenciación de células de mamífero no diferenciadas para dar lugar a osteoblastos
US8188226B2 (en) 2005-11-18 2012-05-29 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh High activity growth factor mutants
PT1989546T (pt) * 2006-02-28 2016-12-05 Centre Nat De La Rech Scient (Cnrs) Rastreio de compostos anti-cancerígenos usando a actividade da netrina-1
GB0604966D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
WO2008089987A1 (en) * 2007-01-25 2008-07-31 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Use of gdf-5 for the improvement or maintenance of dermal appearance
EP2019117A1 (en) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimized purification process of recombinant growth factor protein
JP5837930B2 (ja) 2010-07-30 2015-12-24 ビオファーム・ゲゼルシャフト・ツァ・ビオテヒノロジッシェン・エントヴィックルング・フォン・ファルマカ・エムベーハー 創傷の治癒を加速する医薬送達装置及び増殖因子製剤
CN102382187B (zh) * 2011-05-03 2013-05-22 中国人民解放军军事医学科学院放射与辐射医学研究所 Fbxl15蛋白片段及其编码基因和应用
EP2537538A1 (en) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbable Wound Dressing
EP2602264A1 (en) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5 mutant for inducing cartilage formation
US11464888B2 (en) 2017-06-12 2022-10-11 Warsaw Orthopedic, Inc. Moldable formulations containing an oxysterol in an acellular tissue matrix
EP4076502A1 (en) 2019-12-18 2022-10-26 Merck Patent GmbH Use of the gdf-5 mutant for the treatment of pain and cartilage destruction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158934A (en) * 1989-09-01 1992-10-27 Genentech, Inc. Method of inducing bone growth using TGF-β
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
DE69434651T2 (de) * 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
JPH0931098A (ja) * 1995-07-24 1997-02-04 Hoechst Japan Ltd 新規なタンパク質ｈｍｗヒトｍｐ５２
JPH11335398A (ja) * 1998-05-22 1999-12-07 Hoechst Marion Roussel Kk 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬

Also Published As

Publication number Publication date
ES2272063T3 (es) 2007-04-16
JPH11335398A (ja) 1999-12-07
US7638129B2 (en) 2009-12-29
AU3530999A (en) 1999-12-13
EP1078054B1 (en) 2006-11-22
DE69934110D1 (de) 2007-01-04
US7235241B2 (en) 2007-06-26
WO1999061611A1 (en) 1999-12-02
EP1078054A1 (en) 2001-02-28
ATE346151T1 (de) 2006-12-15
US20060019886A1 (en) 2006-01-26
PT1078054E (pt) 2007-02-28
JP2002516098A (ja) 2002-06-04
US20080318856A1 (en) 2008-12-25
CY1105933T1 (el) 2011-04-06
DE69934110T8 (de) 2007-06-06
DE69934110T2 (de) 2007-03-01
JP4272357B2 (ja) 2009-06-03

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