YU64900A - Promoter humanog bmp-7 i njegova upotreba u postupku ispitivanja supstance koja je srodna kosti - Google Patents

Promoter humanog bmp-7 i njegova upotreba u postupku ispitivanja supstance koja je srodna kosti

Info

Publication number
YU64900A
YU64900A YU64900A YU64900A YU64900A YU 64900 A YU64900 A YU 64900A YU 64900 A YU64900 A YU 64900A YU 64900 A YU64900 A YU 64900A YU 64900 A YU64900 A YU 64900A
Authority
YU
Yugoslavia
Prior art keywords
human bmp
promoter
bone
molecular weight
low molecular
Prior art date
Application number
YU64900A
Other languages
English (en)
Inventor
Shinji Kawai
Takeyuki Sugiura
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of YU64900A publication Critical patent/YU64900A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Abstract

Ovaj pronalazak se odnosi na ispitivanje jedinjenja niske molarne mase koja pozitivno ili negativnoa regulišu ekspresiju humanog BMP-7 u odnosu na aktivnost izvestioca, koristeći oblast gena iznad 5' koju sadrži humani BMP-7 promoter i životinjsku ćeliju unetu sa vektorom, koji je vezan na odgovarajući gen izvestilac. Jedinjenje niske molarne mase i njihovi derivati dobijeni ovim postupkom imaju morfogenetičku aktivnost ili inhibicionu aktivnost na kost i hrskavicu kroz ekspresiju humanog BMP-7, a korisna su terapeutska sredstva za bolesti hrskavice i kosti. Dalje, jedinjenja niske molarne mase i njihovi derivati su korisna terapeutska sredstva za bolesti bubrega.[The present invention provides a method for exploring low molecular weight compounds which regulate positively or negatively the expression of human BMP-7 with reference to a reporter activity by using 5' upstream region gene containing the human BMP-7 promoter and an animal cell introduced with the vector that has been connected to an appropriate reporter gene. The low molecular weight compounds and their derivatives obtained by the present method have morphogenetic activity or inhibiting activity for bone and cartilage through the expression of the human BMP-7 and are useful as preventive or therapeutic agents for cartilage and bone diseases. Furthermore, the low molecular weight compounds and their derivatives are useful as therapeutic agents for kidney diseases.
YU64900A 1998-04-30 1999-04-22 Promoter humanog bmp-7 i njegova upotreba u postupku ispitivanja supstance koja je srodna kosti YU64900A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10120174A JPH11313675A (ja) 1998-04-30 1998-04-30 ヒトｂｍｐ−７プロモーターおよびこれを用いた骨関連物質の探索法

Publications (1)

Publication Number Publication Date
YU64900A true YU64900A (sh) 2003-10-31

Family

ID=14779761

Family Applications (1)

Application Number Title Priority Date Filing Date
YU64900A YU64900A (sh) 1998-04-30 1999-04-22 Promoter humanog bmp-7 i njegova upotreba u postupku ispitivanja supstance koja je srodna kosti

Country Status (26)

Country Link
US (2) US6534268B1 (sh)
EP (1) EP1076713A1 (sh)
JP (1) JPH11313675A (sh)
KR (1) KR20010071193A (sh)
CN (1) CN1170941C (sh)
AP (1) AP1329A (sh)
AU (1) AU769124B2 (sh)
BG (1) BG64780B1 (sh)
BR (1) BR9910585A (sh)
CA (1) CA2326957A1 (sh)
EA (1) EA004509B1 (sh)
EE (1) EE200000627A (sh)
GE (1) GEP20033056B (sh)
HR (1) HRP20000736A2 (sh)
HU (1) HUP0102329A3 (sh)
ID (1) ID26704A (sh)
IL (1) IL139100A0 (sh)
NO (1) NO20005433L (sh)
NZ (1) NZ507625A (sh)
PL (1) PL343817A1 (sh)
SK (1) SK16082000A3 (sh)
TR (1) TR200003182T2 (sh)
UA (1) UA72212C2 (sh)
WO (1) WO1999057293A1 (sh)
YU (1) YU64900A (sh)
ZA (1) ZA200006080B (sh)

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US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20070015701A1 (en) * 2005-06-01 2007-01-18 Samuel Zalipsky Macromolecular conjugates of bone morphogenetic protein-7
PL2078073T3 (pl) * 2006-10-12 2013-12-31 Ethicon Inc Komórki pochodzące z nerki oraz sposoby ich zastosowania w leczeniu i regeneracji tkanki
CA2681317C (en) * 2008-05-16 2013-04-02 Industry Foundation Of Chonnam National University A synthetic peptide containing bone forming peptide 1(bfp 1) for stimulating osteoblast differentiation, and pharmaceutical composition comprising the synthetic peptide
WO2011156590A2 (en) 2010-06-09 2011-12-15 Semprus Biosciences Corp. Non-fouling, anti-microbial, anti-thrombogenic graft compositions
EP2579907A4 (en) 2010-06-09 2016-03-23 Arrow Int Inc ARTICLES HAVING NON-FORMING SURFACES AND PREPARATION METHODS COMPRISING THE PRIMARY LAYER APPLICATION
JP6083071B2 (ja) 2010-06-09 2017-02-22 アロー インターナショナル インコーポレイテッド 非汚染性、抗菌性、抗血栓性グラフトフロム組成物
CA2808655C (en) 2010-08-18 2019-11-26 Emory University Compounds and compositions for ossification and methods related thereto
WO2012116137A2 (en) 2011-02-24 2012-08-30 Emory University Jab1 blocking compositions for ossification and methods related thereto
CA2827392A1 (en) 2011-02-24 2012-08-30 Emory University Noggin blocking compositions for ossification and methods related thereto
AU2012351980B2 (en) 2011-12-14 2015-09-17 Arrow International, Inc. Silicone hydrogel contact lens modified using Lanthanide or Transition metal oxidants
MX2014007204A (es) 2011-12-14 2015-04-14 Semprus Biosciences Corp Proceso de uv de multietapas para crear lentes de contacto modificadas en la superficie.
CA2858730C (en) 2011-12-14 2017-07-18 Semprus Biosciences Corp. Surface modified contact lenses
AU2012368232B2 (en) 2011-12-14 2016-01-07 Arrow International, Inc. Imbibing process for contact lens surface modification
JP2015507761A (ja) 2011-12-14 2015-03-12 センプラス・バイオサイエンシーズ・コーポレイションＳｅｍｐｒｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐ． コンタクトレンズ改質のためのレドックス法
WO2019005563A1 (en) * 2017-06-27 2019-01-03 St. Jude Children's Research Hospital METHODS ASSOCIATED WITH THE ACTIVATION OF THE SIGNALING PATHWAY OF BONE MORPHOGENETIC PROTEINS

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011366A1 (en) * 1989-03-28 1990-10-04 Genetics Institute, Inc. Osteoinductive compositions
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
AU2407192A (en) * 1991-08-01 1993-03-02 Pharmaceutical Discovery Corporation Characterization of specific drug receptors with fluorescent ligands
EP0804573A1 (en) 1994-06-07 1997-11-05 Creative Biomolecules, Inc. Methods and compositions for modulating morphogenic protein expression
US6083690A (en) * 1995-06-02 2000-07-04 Osteoscreen, Inc. Methods and compositions for identifying osteogenic agents
JP2001509010A (ja) 1996-11-22 2001-07-10 アクゾ・ノベル・エヌ・ベー Ｂｍｐ―４プロモーターならびに骨粗鬆症の予防および／または治療用の治療剤のスクリーニングにおけるその用途
US5863790A (en) 1997-05-14 1999-01-26 Minnesota Mining And Manfacturing Company Biological sterility indicator
WO1998054344A2 (en) * 1997-05-29 1998-12-03 Creative Biomolecules, Inc. Modulators of morphogen expression and methods of identifying the same

Also Published As

Publication number Publication date
HRP20000736A2 (en) 2001-10-31
US20030040007A1 (en) 2003-02-27
JPH11313675A (ja) 1999-11-16
HUP0102329A3 (en) 2006-03-28
CN1307643A (zh) 2001-08-08
AU769124B2 (en) 2004-01-15
HUP0102329A2 (hu) 2001-10-28
US6534268B1 (en) 2003-03-18
BG104883A (en) 2001-05-31
AP2000001982A0 (en) 2000-12-31
CA2326957A1 (en) 1999-11-11
NZ507625A (en) 2003-12-19
GEP20033056B (en) 2003-08-25
TR200003182T2 (tr) 2001-02-21
AP1329A (en) 2004-11-22
PL343817A1 (en) 2001-09-10
EA004509B1 (ru) 2004-04-29
IL139100A0 (en) 2001-11-25
CN1170941C (zh) 2004-10-13
NO20005433D0 (no) 2000-10-27
ZA200006080B (en) 2001-10-29
WO1999057293A1 (en) 1999-11-11
NO20005433L (no) 2000-10-27
SK16082000A3 (sk) 2001-05-10
ID26704A (id) 2001-02-01
EA200001130A1 (ru) 2001-04-23
EE200000627A (et) 2002-02-15
AU3163499A (en) 1999-11-23
UA72212C2 (en) 2005-02-15
EP1076713A1 (en) 2001-02-21
BR9910585A (pt) 2001-01-09
BG64780B1 (bg) 2006-03-31
KR20010071193A (ko) 2001-07-28

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