EA200001130A1 - Промотор гена вмп-7 человека и способ анализа с его использованием вещества, связанного с костной тканью - Google Patents

Промотор гена вмп-7 человека и способ анализа с его использованием вещества, связанного с костной тканью

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Publication number
EA200001130A1
EA200001130A1 EA200001130A EA200001130A EA200001130A1 EA 200001130 A1 EA200001130 A1 EA 200001130A1 EA 200001130 A EA200001130 A EA 200001130A EA 200001130 A EA200001130 A EA 200001130A EA 200001130 A1 EA200001130 A1 EA 200001130A1
Authority
EA
Eurasian Patent Office
Prior art keywords
human
human bmp
low
vmp
analysis
Prior art date
Application number
EA200001130A
Other languages
English (en)
Other versions
EA004509B1 (ru
Inventor
Синдзи Каваи
Такеюки Сугиура
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA200001130A1 publication Critical patent/EA200001130A1/ru
Publication of EA004509B1 publication Critical patent/EA004509B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение представляет способ анализа низкомолекулярных соединений, которые позитивно или негативно регулируют экспрессию ВМР-7 человека, на основе уровня активности репортера с использованием 5'-расположенного участка, включающего промотор гена ВМР-7 человека, к которому был присоединен подходящий ген-репортер, и клетки животного, в которую внесен этот вектор. Низкомолекулярные соединения и их производные, полученные в соответствии с заявляемым способом, обладают морфогенетической активностью или ингибиторной активностью в отношении костной и хрящевой тканей, опосредуемыми экспрессией ВМР-7 человека и поэтому они применимы в качестве профилактических или терапевтических средств при заболеваниях костей или хряща. Кроме того, эти низкомолекулярные соединения и их производные применимы в качестве терапевтических средств при лечении болезней почек.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001130A 1998-04-30 1999-04-22 Днк, кодирующая белок-7 морфогенеза кости человека, содержащая промоторную область гена, кодирующего данный белок, и способ ее получения EA004509B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10120174A JPH11313675A (ja) 1998-04-30 1998-04-30 ヒトｂｍｐ−７プロモーターおよびこれを用いた骨関連物質の探索法
PCT/IB1999/000733 WO1999057293A1 (en) 1998-04-30 1999-04-22 Human bmp-7 promoter and method for exploring bone-related substance by using the same

Publications (2)

Publication Number Publication Date
EA200001130A1 true EA200001130A1 (ru) 2001-04-23
EA004509B1 EA004509B1 (ru) 2004-04-29

Family

ID=14779761

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001130A EA004509B1 (ru) 1998-04-30 1999-04-22 Днк, кодирующая белок-7 морфогенеза кости человека, содержащая промоторную область гена, кодирующего данный белок, и способ ее получения

Country Status (26)

Country Link
US (2) US6534268B1 (ru)
EP (1) EP1076713A1 (ru)
JP (1) JPH11313675A (ru)
KR (1) KR20010071193A (ru)
CN (1) CN1170941C (ru)
AP (1) AP1329A (ru)
AU (1) AU769124B2 (ru)
BG (1) BG64780B1 (ru)
BR (1) BR9910585A (ru)
CA (1) CA2326957A1 (ru)
EA (1) EA004509B1 (ru)
EE (1) EE200000627A (ru)
GE (1) GEP20033056B (ru)
HR (1) HRP20000736A2 (ru)
HU (1) HUP0102329A3 (ru)
ID (1) ID26704A (ru)
IL (1) IL139100A0 (ru)
NO (1) NO20005433L (ru)
NZ (1) NZ507625A (ru)
PL (1) PL343817A1 (ru)
SK (1) SK16082000A3 (ru)
TR (1) TR200003182T2 (ru)
UA (1) UA72212C2 (ru)
WO (1) WO1999057293A1 (ru)
YU (1) YU64900A (ru)
ZA (1) ZA200006080B (ru)

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Publication number Priority date Publication date Assignee Title
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20070015701A1 (en) * 2005-06-01 2007-01-18 Samuel Zalipsky Macromolecular conjugates of bone morphogenetic protein-7
PL2078073T3 (pl) * 2006-10-12 2013-12-31 Ethicon Inc Komórki pochodzące z nerki oraz sposoby ich zastosowania w leczeniu i regeneracji tkanki
CA2681317C (en) * 2008-05-16 2013-04-02 Industry Foundation Of Chonnam National University A synthetic peptide containing bone forming peptide 1(bfp 1) for stimulating osteoblast differentiation, and pharmaceutical composition comprising the synthetic peptide
WO2011156590A2 (en) 2010-06-09 2011-12-15 Semprus Biosciences Corp. Non-fouling, anti-microbial, anti-thrombogenic graft compositions
EP2579907A4 (en) 2010-06-09 2016-03-23 Arrow Int Inc ARTICLES HAVING NON-FORMING SURFACES AND PREPARATION METHODS COMPRISING THE PRIMARY LAYER APPLICATION
JP6083071B2 (ja) 2010-06-09 2017-02-22 アロー インターナショナル インコーポレイテッド 非汚染性、抗菌性、抗血栓性グラフトフロム組成物
CA2808655C (en) 2010-08-18 2019-11-26 Emory University Compounds and compositions for ossification and methods related thereto
WO2012116137A2 (en) 2011-02-24 2012-08-30 Emory University Jab1 blocking compositions for ossification and methods related thereto
CA2827392A1 (en) 2011-02-24 2012-08-30 Emory University Noggin blocking compositions for ossification and methods related thereto
AU2012351980B2 (en) 2011-12-14 2015-09-17 Arrow International, Inc. Silicone hydrogel contact lens modified using Lanthanide or Transition metal oxidants
MX2014007204A (es) 2011-12-14 2015-04-14 Semprus Biosciences Corp Proceso de uv de multietapas para crear lentes de contacto modificadas en la superficie.
CA2858730C (en) 2011-12-14 2017-07-18 Semprus Biosciences Corp. Surface modified contact lenses
AU2012368232B2 (en) 2011-12-14 2016-01-07 Arrow International, Inc. Imbibing process for contact lens surface modification
JP2015507761A (ja) 2011-12-14 2015-03-12 センプラス・バイオサイエンシーズ・コーポレイションＳｅｍｐｒｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐ． コンタクトレンズ改質のためのレドックス法
WO2019005563A1 (en) * 2017-06-27 2019-01-03 St. Jude Children's Research Hospital METHODS ASSOCIATED WITH THE ACTIVATION OF THE SIGNALING PATHWAY OF BONE MORPHOGENETIC PROTEINS

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
WO1990011366A1 (en) * 1989-03-28 1990-10-04 Genetics Institute, Inc. Osteoinductive compositions
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
AU2407192A (en) * 1991-08-01 1993-03-02 Pharmaceutical Discovery Corporation Characterization of specific drug receptors with fluorescent ligands
EP0804573A1 (en) 1994-06-07 1997-11-05 Creative Biomolecules, Inc. Methods and compositions for modulating morphogenic protein expression
US6083690A (en) * 1995-06-02 2000-07-04 Osteoscreen, Inc. Methods and compositions for identifying osteogenic agents
JP2001509010A (ja) 1996-11-22 2001-07-10 アクゾ・ノベル・エヌ・ベー Ｂｍｐ―４プロモーターならびに骨粗鬆症の予防および／または治療用の治療剤のスクリーニングにおけるその用途
US5863790A (en) 1997-05-14 1999-01-26 Minnesota Mining And Manfacturing Company Biological sterility indicator
WO1998054344A2 (en) * 1997-05-29 1998-12-03 Creative Biomolecules, Inc. Modulators of morphogen expression and methods of identifying the same

Also Published As

Publication number Publication date
HRP20000736A2 (en) 2001-10-31
US20030040007A1 (en) 2003-02-27
JPH11313675A (ja) 1999-11-16
HUP0102329A3 (en) 2006-03-28
CN1307643A (zh) 2001-08-08
AU769124B2 (en) 2004-01-15
HUP0102329A2 (hu) 2001-10-28
US6534268B1 (en) 2003-03-18
BG104883A (en) 2001-05-31
AP2000001982A0 (en) 2000-12-31
CA2326957A1 (en) 1999-11-11
NZ507625A (en) 2003-12-19
GEP20033056B (en) 2003-08-25
TR200003182T2 (tr) 2001-02-21
AP1329A (en) 2004-11-22
PL343817A1 (en) 2001-09-10
EA004509B1 (ru) 2004-04-29
IL139100A0 (en) 2001-11-25
CN1170941C (zh) 2004-10-13
NO20005433D0 (no) 2000-10-27
ZA200006080B (en) 2001-10-29
WO1999057293A1 (en) 1999-11-11
NO20005433L (no) 2000-10-27
SK16082000A3 (sk) 2001-05-10
YU64900A (sh) 2003-10-31
ID26704A (id) 2001-02-01
EE200000627A (et) 2002-02-15
AU3163499A (en) 1999-11-23
UA72212C2 (en) 2005-02-15
EP1076713A1 (en) 2001-02-21
BR9910585A (pt) 2001-01-09
BG64780B1 (bg) 2006-03-31
KR20010071193A (ko) 2001-07-28

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Legal Events

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PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU