DE3774398D1 - Mittel zur verbesserung der perkutanen absorption, diese enthaltende arzneimittel und methode zu ihrer verwendung. - Google Patents

Mittel zur verbesserung der perkutanen absorption, diese enthaltende arzneimittel und methode zu ihrer verwendung.

Info

Publication number
DE3774398D1
DE3774398D1 DE8787310141T DE3774398T DE3774398D1 DE 3774398 D1 DE3774398 D1 DE 3774398D1 DE 8787310141 T DE8787310141 T DE 8787310141T DE 3774398 T DE3774398 T DE 3774398T DE 3774398 D1 DE3774398 D1 DE 3774398D1
Authority
DE
Germany
Prior art keywords
dioxacycloalkanes
agents
products containing
percutaneous absorption
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787310141T
Other languages
English (en)
Inventor
Carlos M Samour
Stefanos Daskalakis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macrochem Corp
Original Assignee
Macrochem Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrochem Corp filed Critical Macrochem Corp
Application granted granted Critical
Publication of DE3774398D1 publication Critical patent/DE3774398D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
DE8787310141T 1986-11-17 1987-11-17 Mittel zur verbesserung der perkutanen absorption, diese enthaltende arzneimittel und methode zu ihrer verwendung. Expired - Lifetime DE3774398D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/931,653 US4861764A (en) 1986-11-17 1986-11-17 Percutaneous absorption enhancers, compositions containing same and method of use

Publications (1)

Publication Number Publication Date
DE3774398D1 true DE3774398D1 (de) 1991-12-12

Family

ID=25461144

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787310141T Expired - Lifetime DE3774398D1 (de) 1986-11-17 1987-11-17 Mittel zur verbesserung der perkutanen absorption, diese enthaltende arzneimittel und methode zu ihrer verwendung.

Country Status (7)

Country Link
US (1) US4861764A (de)
EP (1) EP0268460B1 (de)
AT (1) ATE69168T1 (de)
CA (1) CA1313619C (de)
DE (1) DE3774398D1 (de)
ES (1) ES2038676T3 (de)
GR (1) GR3003238T3 (de)

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EP0576605A4 (en) * 1991-03-19 1994-06-08 Vithal J Rajadhyaksha Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers
ES2120477T3 (es) * 1992-01-21 1998-11-01 Macrochem Corp Administracion iontoforetica de medicamentos perfeccionada.
WO1994004523A1 (en) * 1992-08-21 1994-03-03 Japan Tobacco Inc. Dioxacycloalkane compound with renin-inhibiting activity
US5334615A (en) * 1992-12-17 1994-08-02 Walles Wilhelm E Oil with bactericidal and virucidal properties
US5637616A (en) * 1993-06-18 1997-06-10 Arcturus Pharmaceutical Corporation Method for treating diseases mediated by proteases
US5620980A (en) 1995-02-22 1997-04-15 Macrochem Corporation Method for treating hair loss
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
AU4136597A (en) * 1996-09-10 1998-04-02 Daiso Co. Ltd. Process for preparing 1,3-dioxolane-4-methanol compounds
AU4136697A (en) * 1996-09-10 1998-04-02 Daiso Co. Ltd. Process for preparing 1,3-dioxolane-4-methanol compounds
DE19711758C2 (de) * 1997-03-21 2003-06-18 Degussa Verfahren zur Herstellung von 1,3-Dioxanverbindungen
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
US5968919A (en) * 1997-10-16 1999-10-19 Macrochem Corporation Hormone replacement therapy drug formulations for topical application to the skin
US6153769A (en) * 1997-11-27 2000-11-28 Roche Vitamins Inc. Manufacture of polyene aldehydes
WO1999039680A1 (en) * 1998-02-09 1999-08-12 Macrochem Corporation Antifungal nail lacquer and method using same
US5942545A (en) * 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
DE69933775T2 (de) * 1998-08-20 2007-10-04 3M Innovative Properties Co., St. Paul Sprühverband und wirkstoffabgabesystem
US7537773B1 (en) * 1998-08-25 2009-05-26 Botulinum Toxin Research Associates, Inc. Chemodenervating pharmaceutical as anti-inflammatory agent
US20070191320A1 (en) * 1998-12-10 2007-08-16 Nexmed Holdings, Inc. Methods of treatment for female sexual arousal disorder
US6486207B2 (en) 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6825234B2 (en) 1998-12-10 2004-11-30 Nexmed (Holdings) , Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6596266B2 (en) 2000-02-18 2003-07-22 Natural Science, Inc. Compositions containing minoxidil and saw palmetto for treating baldness
US7241731B2 (en) 2000-06-05 2007-07-10 Sumitomo Electric Industries, Ltd. Oligopeptides for promoting hair growth
US20050008602A1 (en) * 2000-06-05 2005-01-13 Sumitomo Electric Industries, Ltd. Oligopeptides for promoting hair growth
US20030139384A1 (en) * 2000-08-30 2003-07-24 Dudley Robert E. Method for treating erectile dysfunction and increasing libido in men
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
EP1443964B1 (de) * 2001-11-09 2008-02-20 QLT Inc. Photodynamische therapie zur behandlung von haarausfall
UA80964C2 (en) * 2002-03-15 2007-11-26 Unimed Pharmaceuticals Inc Method for treating depression and kit therefor
US20040241244A1 (en) * 2003-03-21 2004-12-02 Nexmed (Holdings) Inc. Neuronal growth enhancement by prostaglandin compositions and methods
US7462362B2 (en) 2003-03-21 2008-12-09 Nexmed Holdings, Inc. Antifungal nail coat and method of use
DE10314976A1 (de) * 2003-04-02 2004-10-14 Bayer Healthcare Ag Verbesserte Penetration von Wirkstoffen in Zellen und Organe
KR20050041815A (ko) * 2003-10-31 2005-05-04 싸이토팜(주) 자외선에 의한 피부손상을 경감시키는 항산화 조성물
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
FR2869232B1 (fr) * 2004-04-21 2007-09-21 Gattefosse Sas Soc Par Actions Nouveaux excipients pharmaceutiques ou cosmetiques a base d'acetals cyliques
EP1865896A1 (de) * 2005-03-14 2007-12-19 MacroChem Corporation Verstärkung der makrolid-penetration durch menschliche haut
MX2007013912A (es) * 2005-05-11 2008-03-25 Macrochem Corp Administracion de baja dosis de una composicion topica.
GT200600397A (es) * 2005-09-07 2007-08-28 Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales
GT200600396A (es) * 2005-09-07 2007-04-23 Dispositivos para la aplicacion de medicamentos transdermicos conteniendo o-desmetil venlafaxina (odv) o sus sales
US8187639B2 (en) 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
EP1933852B1 (de) 2005-09-27 2018-12-19 TissueTech, Inc. Amnion-zubereitungen und gereinigte zusammensetzungen und anwendungsverfahren
JP5584415B2 (ja) 2005-10-12 2014-09-03 ユニメッド・ファーマシューティカルズ・エルエルシー 改良したテストステロンゲル製剤及び使用の方法
WO2007051243A1 (en) 2005-11-04 2007-05-10 Acrux Dds Pty Ltd Method and system for transdermal drug delivery
CA3006143C (en) 2007-10-10 2021-10-19 Therametics, Llc Methods and compositions for treating dermatological diseases and conditions
JP5832451B2 (ja) * 2010-06-11 2015-12-16 株式会社ポーラファルマ 抗真菌医薬組成物
CA2837878A1 (en) 2011-06-10 2012-12-13 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
US9931423B2 (en) 2011-08-26 2018-04-03 Tissuetech, Inc. Methods of sterilizing fetal support tissues
MX370929B (es) 2012-10-28 2020-01-08 Revance Therapeutics Inc Composiciones y usos de las mismas para el tratamiento seguro de la rinitis.
WO2016081599A1 (en) 2014-11-18 2016-05-26 Rutgers, The State University Of New Jersey Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer
EP3458454B1 (de) 2016-05-18 2021-11-24 Rutgers, The State University of New Jersey 2-hydroxy-n-(benzo[d]thiazol-2-yl)benzamid-derivate als mitochondrien-entkoppler zur behandlung von stoffwechselerkrankungen und krebs

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DE1082370B (de) * 1958-01-18 1960-05-25 C F Asche & Co Ag Verfahren zur Herstellung von verformbaren Massen fuer kosmetische und pharmazeutische Zwecke
GB1385914A (en) * 1971-10-19 1975-03-05 Wigglesworth Ltd Compositions having bactericidal activity
US4012520A (en) * 1973-08-08 1977-03-15 The Upjohn Company Composition and method of producing infertility in male rodents
GB1448458A (en) * 1973-11-21 1976-09-08 Allen & Hanburys Ltd 1,3-dioxan derivatives and pharmaceutical compositions thereof
IT1037122B (it) * 1975-04-01 1979-11-10 Maggioni E C S P A Derivati alogenati dell 1 3 dios solano ad attivita mucolitica
ATE3292T1 (de) * 1978-11-30 1983-05-15 Imperial Chemical Industries Plc Zusammensetzungen, die 1,3 dioxolane als aufweichmittel enthalten.
CA1225594A (en) * 1983-05-20 1987-08-18 Jourge Heller Method for percutaneously administering physiologically active agents
US4557934A (en) * 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one

Also Published As

Publication number Publication date
EP0268460A1 (de) 1988-05-25
ES2038676T3 (es) 1993-08-01
US4861764A (en) 1989-08-29
ATE69168T1 (de) 1991-11-15
EP0268460B1 (de) 1991-11-06
CA1313619C (en) 1993-02-16
GR3003238T3 (en) 1993-02-17

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Legal Events

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