HUP0003745A2 - Eljárások és készítmények tumorspecifikus citotoxicitás indukálására - Google Patents

Eljárások és készítmények tumorspecifikus citotoxicitás indukálására

Info

Publication number
HUP0003745A2
HUP0003745A2 HU0003745A HUP0003745A HUP0003745A2 HU P0003745 A2 HUP0003745 A2 HU P0003745A2 HU 0003745 A HU0003745 A HU 0003745A HU P0003745 A HUP0003745 A HU P0003745A HU P0003745 A2 HUP0003745 A2 HU P0003745A2
Authority
HU
Hungary
Prior art keywords
compositions
methods
specific cytotoxicity
inducing tumor
tumor cells
Prior art date
Application number
HU0003745A
Other languages
English (en)
Inventor
Suhail Ayesh
Abraham Hochberg
Original Assignee
Yissum Research Development Company Of The Hebrew University Of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Company Of The Hebrew University Of Jerusalem filed Critical Yissum Research Development Company Of The Hebrew University Of Jerusalem
Publication of HUP0003745A2 publication Critical patent/HUP0003745A2/hu
Publication of HUP0003745A3 publication Critical patent/HUP0003745A3/hu
Publication of HU228470B1 publication Critical patent/HU228470B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány heterológ gének, különösen citotoxikus termékeket kódológének specifikus expressziójára vonatkozik tumorsejtekben. Azexpressziót úgy hajtják végre, hogy egy citotoxikus génterméket kódolóheterológ szekvenciát és egy ahhoz működőképesen kapcsoltszabályozószekvenciát tartalmazó polinukleotidot visznek be atumorsejtekbe, mely szabályozószekvencia egy tumorsejtben specifikusanexpresszálódó, genomiális imprintingen átesett génből származik, vagyaz IGF-1 promoter. Továbbá a találmány tárgyát képezi a fentipolinukleotidot tartalmazó vektor is. A találmány a rákosmegbetegedések kezelésére alkalmazható. Ó
HU0003745A 1997-10-03 1998-10-04 Methods and compositions for inducing tumor-specific cytotoxicity HU228470B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94360897A 1997-10-03 1997-10-03
PCT/IL1998/000486 WO1999018195A2 (en) 1997-10-03 1998-10-04 Methods and compositions for inducing tumor-specific cytotoxicity

Publications (3)

Publication Number Publication Date
HUP0003745A2 true HUP0003745A2 (hu) 2001-02-28
HUP0003745A3 HUP0003745A3 (en) 2002-04-29
HU228470B1 HU228470B1 (en) 2013-03-28

Family

ID=25479934

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003745A HU228470B1 (en) 1997-10-03 1998-10-04 Methods and compositions for inducing tumor-specific cytotoxicity

Country Status (17)

Country Link
US (2) US6087164A (hu)
EP (1) EP1019499B1 (hu)
JP (3) JP5153031B2 (hu)
KR (1) KR100524262B1 (hu)
CN (1) CN1229496C (hu)
AT (1) ATE407948T1 (hu)
AU (1) AU755774B2 (hu)
BR (1) BR9812717B1 (hu)
CA (1) CA2308124C (hu)
CZ (2) CZ294941B6 (hu)
DE (1) DE69840001D1 (hu)
HU (1) HU228470B1 (hu)
IL (1) IL135430A0 (hu)
NO (2) NO328470B1 (hu)
PL (1) PL339949A1 (hu)
RU (1) RU2214280C2 (hu)
WO (1) WO1999018195A2 (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040006220A1 (en) * 2002-07-02 2004-01-08 Isis Pharmaceuticals Inc. Antisense modulation of insulin-like growth factor 2 expression
US7041654B2 (en) 1997-10-03 2006-05-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for inducing tumor-specific cytotoxicity
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
EP1169480A4 (en) * 1999-04-14 2005-02-02 Musc Found For Res Dev TISSUE-SPECIFIC AND PATHOGENIC TOXIC SUBSTANCES AND RIBOZYMES
DE19928342A1 (de) * 1999-06-21 2000-12-28 Deutsches Krebsforsch Vektoren zur gentherapeutischen Tumorbehandlung
US7829693B2 (en) * 1999-11-24 2010-11-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
WO2002046449A2 (en) * 2000-12-07 2002-06-13 The Penn State Research Foundation Selection of catalytic nucleic acids targeted to infectious agents
US8546143B2 (en) 2001-01-09 2013-10-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
US20040005567A1 (en) * 2002-07-02 2004-01-08 Isis Pharmaceuticals Inc. Antisense modulation of cyclin-dependent kinase 4 expression
WO2003102186A1 (fr) * 2002-05-31 2003-12-11 Medinet Co., Ltd. Adn induisant l'expression specifique des cellules cancereuses et vecteur d'expression specifique des cellules cancereuses
US20040180844A1 (en) * 2003-03-10 2004-09-16 Fesik Stephen W. Method of killing cancer cells
US20040219099A1 (en) * 2003-05-02 2004-11-04 Jasbir Sandhu Method for the treatment of tumors
US20040220085A1 (en) * 2003-05-02 2004-11-04 Jasbir Sandhu Compositions for nucleic acid delivery
US7482156B2 (en) * 2003-10-15 2009-01-27 Cell Genesys, Inc. Hepatocellular carcinoma specific promoter and uses thereof
US7063947B2 (en) * 2004-04-08 2006-06-20 Promogen, Inc. System for producing synthetic promoters
US7429482B2 (en) * 2005-01-13 2008-09-30 United States Of America As Represented By The Department Of Veterans Affairs Screening tools for discovery of novel anabolic agents
CA2614531C (en) 2005-07-07 2015-06-16 Avraham Hochberg Nucleic acid agents for downregulating h19, and methods of using same
JP2009508516A (ja) 2005-09-22 2009-03-05 イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム 核酸構築物、薬剤組成物、及び癌治療のためのその使用方法
CA2675964C (en) * 2007-01-16 2015-12-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem H19 silencing nucleic acid agents for treating rheumatoid arthritis
EP2205249B1 (en) 2007-09-28 2018-11-07 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
AU2008315409B2 (en) * 2007-10-25 2013-10-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Constructs containing multiple expression cassettes for cancer therapy
RU2511395C2 (ru) 2008-07-02 2014-04-10 Оцука Фармасьютикал Фэктори, Инк. Предшественник искусственной почки и способ его получения
JP2012515532A (ja) 2009-01-20 2012-07-12 ラモット アット テル アビブ ユニバーシティ， リミテッド Ｍｉｒ−２１プロモーター駆動性標的がん治療
EA016223B1 (ru) * 2009-10-07 2012-03-30 Учреждение Российской Академии Наук Институт Молекулярной Генетики Ран Способ и генная конструкция для высокоспецифичного ингибирования нежелательного роста клеток
EP3291799A1 (en) * 2015-05-05 2018-03-14 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Nucleic acid-cationic polymer compositions and methods of making and using the same
US10874750B2 (en) * 2018-04-30 2020-12-29 Amicus Therapeutics, Inc. Gene therapy constructs and methods of use
CN110714075B (zh) * 2018-07-13 2024-05-03 立森印迹诊断技术（无锡）有限公司 一种用于检测肺肿瘤良恶性程度的分级模型及其应用
CN111206093A (zh) * 2018-11-21 2020-05-29 立森印迹诊断技术（无锡）有限公司 一种用于检测浸润性膀胱癌的标志物及其应用
CN109609505A (zh) * 2019-01-14 2019-04-12 中国科学院成都生物研究所 一种体内筛选的剪切rna的锤头状核酶

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2699191B1 (fr) * 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
IL108879A (en) * 1994-03-07 2000-08-31 Yissum Res Dev Co Diagnostic assay for malignancies using the H19 gene and kit
FR2723697B1 (fr) * 1994-08-17 1996-09-20 Rhone Poulenc Rorer Sa Methode de traitement de la restenose par la therapie genique
FR2725213B1 (fr) * 1994-10-04 1996-11-08 Rhone Poulenc Rorer Sa Vecteurs viraux et utilisation en therapie genique

Also Published As

Publication number Publication date
IL135430A0 (en) 2001-05-20
NO328470B1 (no) 2010-02-22
CN1229496C (zh) 2005-11-30
ATE407948T1 (de) 2008-09-15
BR9812717B1 (pt) 2011-06-28
NO20001684L (no) 2000-06-02
EP1019499A2 (en) 2000-07-19
AU9457198A (en) 1999-04-27
PL339949A1 (en) 2001-01-15
CZ294941B6 (cs) 2005-04-13
JP2006304801A (ja) 2006-11-09
JP5153031B2 (ja) 2013-02-27
JP2001519148A (ja) 2001-10-23
EP1019499B1 (en) 2008-09-10
AU755774B2 (en) 2002-12-19
WO1999018195A2 (en) 1999-04-15
NO20001684D0 (no) 2000-03-31
JP2008136480A (ja) 2008-06-19
CZ294694B6 (cs) 2005-02-16
NO331723B1 (no) 2012-03-05
KR100524262B1 (ko) 2005-10-28
HUP0003745A3 (en) 2002-04-29
DE69840001D1 (de) 2008-10-23
WO1999018195A3 (en) 1999-08-12
CZ20001201A3 (cs) 2000-09-13
US6087164A (en) 2000-07-11
CA2308124C (en) 2008-07-08
BR9812717A (pt) 2000-08-22
US6306833B1 (en) 2001-10-23
HU228470B1 (en) 2013-03-28
NO20093194L (no) 2000-06-02
CN1280616A (zh) 2001-01-17
KR20010030912A (ko) 2001-04-16
RU2214280C2 (ru) 2003-10-20
CA2308124A1 (en) 1999-04-15

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