HUP0102844A2 - Deszaturáz-gének kukorica lipidösszetételének megváltoztatására - Google Patents
Deszaturáz-gének kukorica lipidösszetételének megváltoztatásáraInfo
- Publication number
- HUP0102844A2 HUP0102844A2 HU0102844A HUP0102844A HUP0102844A2 HU P0102844 A2 HUP0102844 A2 HU P0102844A2 HU 0102844 A HU0102844 A HU 0102844A HU P0102844 A HUP0102844 A HU P0102844A HU P0102844 A2 HUP0102844 A2 HU P0102844A2
- Authority
- HU
- Hungary
- Prior art keywords
- corn
- desaturases
- oleosin promoter
- genes encoding
- nucleic acid
- Prior art date
Links
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 title abstract 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 title abstract 4
- 235000005822 corn Nutrition 0.000 title abstract 4
- 101710089395 Oleosin Proteins 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 241000209149 Zea Species 0.000 title 2
- 240000008042 Zea mays Species 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 241001057636 Dracaena deremensis Species 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/001—Refining fats or fatty oils by a combination of two or more of the means hereafter
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B7/00—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
- C11C1/04—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
- C11C3/10—Ester interchange
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/12—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by hydrogenation
- C11C3/123—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by hydrogenation using catalysts based principally on nickel or derivates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
- C12N15/823—Reproductive tissue-specific promoters
- C12N15/8234—Seed-specific, e.g. embryo, endosperm
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physiology (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Botany (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Fats And Perfumes (AREA)
- Edible Oils And Fats (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
A találmány tárgyát kukorica lipidösszetételének módosítására -önmagukban vagy egymással kombinálva - alkalmas, teljes vagylényegében teljes kukorica oleozin-promóter, sztearoil-ACP-deszaturázés delta-12-deszaturáz tartalmú nukleinsavfragmensek előállítása ésalkalmazása képezi. A találmány szerinti nukleinsavfragmenseket ésalkalmas szabályozó szekvenciákat tartalmazó kiméragének segítségévelmegváltozott lipidösszetételű transzgenikus kukoricanövényekállíthatók elő. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8898798P | 1998-06-11 | 1998-06-11 | |
PCT/US1999/012884 WO1999064579A2 (en) | 1998-06-11 | 1999-06-09 | Corn oleosin promoter and genes encoding corn desaturases |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0102844A2 true HUP0102844A2 (hu) | 2001-11-28 |
HUP0102844A3 HUP0102844A3 (en) | 2003-04-28 |
Family
ID=22214681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102844A HUP0102844A3 (en) | 1998-06-11 | 1999-06-09 | Corn oleosin promoter and genes encoding corn desaturases |
Country Status (12)
Country | Link |
---|---|
US (1) | US7008664B1 (hu) |
EP (1) | EP1086235A2 (hu) |
JP (1) | JP2002517984A (hu) |
CN (1) | CN1305532A (hu) |
AR (1) | AR019863A1 (hu) |
AU (1) | AU4553899A (hu) |
BR (1) | BR9911525A (hu) |
CA (2) | CA2779549A1 (hu) |
HU (1) | HUP0102844A3 (hu) |
ID (1) | ID27037A (hu) |
WO (1) | WO1999064579A2 (hu) |
ZA (1) | ZA200006267B (hu) |
Families Citing this family (63)
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US6307123B1 (en) | 1998-05-18 | 2001-10-23 | Dekalb Genetics Corporation | Methods and compositions for transgene identification |
US7531718B2 (en) | 1999-08-26 | 2009-05-12 | Monsanto Technology, L.L.C. | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
US7067722B2 (en) | 1999-08-26 | 2006-06-27 | Monsanto Technology Llc | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
DE60037735T2 (de) | 1999-08-26 | 2009-01-02 | Calgene Llc, Davis | Pflanzen mit veränderten mehrfachungesättigten fettsäuren |
FR2810994B1 (fr) * | 2000-06-30 | 2004-03-12 | Biogemma Fr | Acides nucleiques codant pour une phosphatase vegetale de type mipp a activite phytasique et applications |
AU2001273454A1 (en) | 2000-07-13 | 2002-01-30 | Pioneer Hi-Bred International, Inc. | ZmaXIG1 polynucleotides and methods of use |
US20070067865A1 (en) * | 2000-09-05 | 2007-03-22 | Kovalic David K | Annotated plant genes |
US7294759B2 (en) | 2001-06-29 | 2007-11-13 | E. I. Du Pont De Nemours And Company | Alteration of oil traits in plants |
US7211656B2 (en) * | 2002-01-30 | 2007-05-01 | Abbott Laboratories | Desaturase genes, enzymes encoded thereby, and uses thereof |
US7566813B2 (en) | 2002-03-21 | 2009-07-28 | Monsanto Technology, L.L.C. | Nucleic acid constructs and methods for producing altered seed oil compositions |
US7166771B2 (en) | 2002-06-21 | 2007-01-23 | Monsanto Technology Llc | Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs |
BR0308614A (pt) | 2002-03-21 | 2005-02-09 | Monsanto Technology Llc | Construções de ácidos nucléicos e processos para a produção de composições oleosas de sementes alteradas |
US7179959B2 (en) | 2002-05-03 | 2007-02-20 | Renessen Llc | Temporal seed promoters for expressing genes in plants |
US7205454B2 (en) * | 2002-07-31 | 2007-04-17 | Bayer Bioscience N.V. | Corn root preferential promoters and uses thereof |
CN101120091A (zh) * | 2004-12-20 | 2008-02-06 | 巴斯福植物科学有限公司 | 编码植物脂肪酸去饱和酶基因的核酸分子及其使用方法 |
CN101213302B (zh) * | 2005-07-01 | 2012-09-05 | 康乃尔研究基金会 | 咖啡油质蛋白基因和启动子 |
CN101421406B (zh) | 2006-02-13 | 2016-08-31 | 孟山都技术有限公司 | 用于产生改变的种子油组成的核酸构建体和方法 |
US7465793B2 (en) * | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
US7777102B2 (en) | 2007-02-08 | 2010-08-17 | University Of Tennessee Research Foundation | Soybean varieties |
CN101715291A (zh) * | 2007-06-18 | 2010-05-26 | 农业经济有限责任公司 | 具有改变的油、蛋白或纤维含量的植物的生产 |
CA2738474C (en) | 2008-09-29 | 2020-05-12 | Monsanto Technology Llc | Soybean transgenic event mon87705 and methods for detection thereof |
CA2758824A1 (en) | 2009-04-17 | 2010-10-21 | Basf Plant Science Company Gmbh | Plant promoter operable in endosperm and uses thereof |
CA2765034A1 (en) | 2009-06-09 | 2010-12-23 | Pioneer Hi-Bred International, Inc. | Early endosperm promoter and methods of use |
BR112012009044A2 (pt) | 2009-10-26 | 2015-09-01 | Pioneer Hi Bred Int | Molécula de ácido nucléico isolada, cassete de expressão, vetor, célula vegetal, planta, semente transgênica, método para expressão de um polinucleotídeo em uma planta ou célula vegetal e método para expressão de um polinucleotídeo, preferencialmente em tecidos somáticos de óvulo de uma planta |
US20110126319A1 (en) * | 2009-11-24 | 2011-05-26 | Pioneer Hi-Bred International, Inc. | Plants Having Increased Oil, Oleic Acid Content and Digestibility and Methods of Producing Same |
PL2512226T3 (pl) * | 2009-12-17 | 2019-10-31 | Pioneer Hi Bred Int | Modyfikacja DP-004114-3 kukurydzy i sposoby jej wykrywania |
WO2013096810A1 (en) | 2011-12-21 | 2013-06-27 | The Curators Of The University Of Missouri | Soybean variety s05-11482 |
US20130167262A1 (en) | 2011-12-21 | 2013-06-27 | The Curators Of The University Of Missouri | Soybean variety s05-11268 |
WO2013103371A1 (en) | 2012-01-06 | 2013-07-11 | Pioneer Hi-Bred International, Inc. | Ovule specific promoter and methods of use |
WO2013103365A1 (en) | 2012-01-06 | 2013-07-11 | Pioneer Hi-Bred International, Inc. | Pollen preferred promoters and methods of use |
US20150259696A1 (en) | 2012-10-11 | 2015-09-17 | Shane E. Abbitt | Guard cell promoters and uses thereof |
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CA2902002C (en) | 2013-03-14 | 2023-08-01 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
RU2015143825A (ru) | 2013-03-15 | 2017-04-26 | Пайонир Хай-Бред Интернэшнл, Инк. | Полипептиды phi-4 и способы их применения |
US10006045B2 (en) | 2013-08-16 | 2018-06-26 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
ES2937045T3 (es) | 2013-09-13 | 2023-03-23 | Pioneer Hi Bred Int | Proteínas insecticidas y métodos para su uso |
WO2015040856A1 (ja) * | 2013-09-18 | 2015-03-26 | 日清オイリオグループ株式会社 | 油脂および油脂含有食品 |
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CN104195169A (zh) * | 2014-08-29 | 2014-12-10 | 兰州理工大学 | 一种基于脂肪酸去饱和酶基因的抗寒转基因烟草的构建方法 |
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BR112018072417B1 (pt) | 2016-05-04 | 2023-03-14 | E. I. Du Pont De Nemours And Company | Polipeptídeo inseticida recombinante, polipeptídeo quimérico, composição, polinucleotídeo recombinante, construtos de dna, métodos para obter uma planta transgênica, métodos para inibir o crescimento ou extermínio de uma praga de inseto ou população de praga, método para obter uma célula procariótica transformada, célula procariótica transformada e método para modificar geneticamente o polipeptídeo inseticida |
CN109312359A (zh) | 2016-06-16 | 2019-02-05 | 先锋国际良种公司 | 用以防治昆虫有害生物的组合物和方法 |
ES2924552T3 (es) | 2016-06-24 | 2022-10-07 | Pioneer Hi Bred Int | Elementos reguladores de las plantas y métodos de uso de los mismos |
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US5706603A (en) | 1990-11-16 | 1998-01-13 | E. I. Du Pont De Nemours And Company | Production method for corn with enhanced quality grain traits |
DK0563191T4 (da) | 1990-12-20 | 2000-07-17 | Du Pont | Nucleotidsekvenser af sojabønne-acyl-ACP-thioesterase-gener |
CA2118113C (en) | 1991-02-22 | 2002-01-08 | Maurice M. Moloney | Oil-body proteins as carriers of high-value peptides in plants |
EP0668919B1 (en) | 1992-11-17 | 2003-06-04 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants |
US5437998A (en) * | 1993-09-09 | 1995-08-01 | Synthecon, Inc. | Gas permeable bioreactor and method of use |
MX9603376A (es) | 1994-02-15 | 1997-03-29 | Du Pont | Plantas y productos de maiz con composicion mejorada de aceite. |
US6350934B1 (en) * | 1994-09-02 | 2002-02-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid encoding delta-9 desaturase |
CN1196091A (zh) | 1995-07-13 | 1998-10-14 | 里伯希姆药品公司 | 用于在植物中调节基因表达的组合物和方法 |
EP0794250A1 (en) | 1996-03-04 | 1997-09-10 | Soremartec S.A. | Isolation and sequencing of the hazel FAd2-N gene |
US6307123B1 (en) * | 1998-05-18 | 2001-10-23 | Dekalb Genetics Corporation | Methods and compositions for transgene identification |
-
1999
- 1999-06-07 US US09/326,285 patent/US7008664B1/en not_active Expired - Fee Related
- 1999-06-09 AU AU45538/99A patent/AU4553899A/en not_active Abandoned
- 1999-06-09 CA CA2779549A patent/CA2779549A1/en not_active Abandoned
- 1999-06-09 HU HU0102844A patent/HUP0102844A3/hu unknown
- 1999-06-09 CN CN99807225A patent/CN1305532A/zh active Pending
- 1999-06-09 JP JP2000553569A patent/JP2002517984A/ja active Pending
- 1999-06-09 EP EP99928481A patent/EP1086235A2/en not_active Withdrawn
- 1999-06-09 ID IDW20002581A patent/ID27037A/id unknown
- 1999-06-09 WO PCT/US1999/012884 patent/WO1999064579A2/en active Application Filing
- 1999-06-09 CA CA2327529A patent/CA2327529C/en not_active Expired - Fee Related
- 1999-06-09 BR BR9911525-5A patent/BR9911525A/pt not_active IP Right Cessation
- 1999-06-11 AR ARP990102808A patent/AR019863A1/es not_active Application Discontinuation
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2000
- 2000-11-02 ZA ZA200006267A patent/ZA200006267B/en unknown
Also Published As
Publication number | Publication date |
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CN1305532A (zh) | 2001-07-25 |
ID27037A (id) | 2001-02-22 |
ZA200006267B (en) | 2002-02-04 |
AR019863A1 (es) | 2002-03-20 |
US7008664B1 (en) | 2006-03-07 |
BR9911525A (pt) | 2001-10-09 |
EP1086235A2 (en) | 2001-03-28 |
WO1999064579A9 (en) | 2000-03-16 |
HUP0102844A3 (en) | 2003-04-28 |
AU4553899A (en) | 1999-12-30 |
WO1999064579A2 (en) | 1999-12-16 |
WO1999064579A3 (en) | 2000-06-29 |
CA2327529C (en) | 2012-08-21 |
JP2002517984A (ja) | 2002-06-25 |
CA2327529A1 (en) | 1999-12-16 |
CA2779549A1 (en) | 1999-12-16 |
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