SG10201909209RA - Nucleic acid-cationic polymer compositions and methods of making and using the same - Google Patents
Nucleic acid-cationic polymer compositions and methods of making and using the sameInfo
- Publication number
- SG10201909209RA SG10201909209RA SG10201909209RA SG10201909209RA SG 10201909209R A SG10201909209R A SG 10201909209RA SG 10201909209R A SG10201909209R A SG 10201909209RA SG 10201909209R A SG10201909209R A SG 10201909209RA
- Authority
- SG
- Singapore
- Prior art keywords
- making
- methods
- nucleic acid
- same
- cationic polymer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Provided herein are pre-lyophilized compositions containing a nucleic acid, a cationic polymer, and a carbohydrate. Also provided are lyophilized compositions of matter and reconstituted compositions as well as methods of making using the same for treating tumors in patients. No Figure.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL23864315 | 2015-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201909209RA true SG10201909209RA (en) | 2019-11-28 |
Family
ID=56134418
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201909209R SG10201909209RA (en) | 2015-05-05 | 2016-05-05 | Nucleic acid-cationic polymer compositions and methods of making and using the same |
SG11201708760PA SG11201708760PA (en) | 2015-05-05 | 2016-05-05 | Nucleic acid-cationic polymer compositions and methods of making and using the same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201708760PA SG11201708760PA (en) | 2015-05-05 | 2016-05-05 | Nucleic acid-cationic polymer compositions and methods of making and using the same |
Country Status (14)
Country | Link |
---|---|
US (2) | US20180154023A1 (en) |
EP (1) | EP3291799A1 (en) |
JP (2) | JP2018515479A (en) |
KR (1) | KR20180015145A (en) |
CN (1) | CN107735079A (en) |
AU (1) | AU2016258326A1 (en) |
BR (1) | BR112017023788A2 (en) |
CA (1) | CA2984879A1 (en) |
IL (1) | IL255254A0 (en) |
MX (1) | MX2017014060A (en) |
PH (1) | PH12017502216A1 (en) |
RU (1) | RU2017140065A (en) |
SG (2) | SG10201909209RA (en) |
WO (1) | WO2016178233A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201909209RA (en) * | 2015-05-05 | 2019-11-28 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Nucleic acid-cationic polymer compositions and methods of making and using the same |
DE102017003004A1 (en) | 2017-03-23 | 2018-09-27 | Friedrich-Schiller-Universität Jena | Cationic polymers with D-fructose substituents |
EP3448363B1 (en) | 2017-05-17 | 2022-05-11 | Highlight Therapeutics, S.L. | Novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine |
WO2020165656A1 (en) * | 2019-02-11 | 2020-08-20 | Excellgene S.A. | Novel eukaryotic cell transfection systems and related methods |
CN111363761A (en) * | 2020-03-17 | 2020-07-03 | 苏州吉恒基因科技有限公司 | Method for promoting AAV-mediated gene expression by using cationic polymer DNA complex |
WO2021222133A1 (en) * | 2020-04-27 | 2021-11-04 | Juno Therapeutics, Inc. | Stabilization of polyethyleneimine-deoxyribonucleic acid complex size and activity |
US20240245720A1 (en) | 2021-05-25 | 2024-07-25 | Ramot At Tel-Aviv University Ltd. | Compositions comprising extracellular vesicles and an active agent and uses thereof |
CN113501889A (en) * | 2021-07-06 | 2021-10-15 | 郑州大学 | Preparation method and application of pseudo-ginseng polysaccharide cationic derivative |
CN116549626A (en) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | Nucleic acid-loaded lipid nanoparticle freeze-dried preparation and preparation method and application thereof |
CN114762731B (en) * | 2022-05-16 | 2024-08-23 | 常州大学 | Method for prolonging storage time of gene medicine under mild condition |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
FR2722506B1 (en) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | COMPOSITION CONTAINING NUCLEIC ACIDS, PREPARATION AND USES |
US6087164A (en) | 1997-10-03 | 2000-07-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for inducing tumor-specific cytotoxicity |
US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
WO2007007317A1 (en) | 2005-07-07 | 2007-01-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid agents for downregulating h19, and methods of using same |
JP2009508516A (en) | 2005-09-22 | 2009-03-05 | イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム | Nucleic acid constructs, pharmaceutical compositions, and methods of use thereof for cancer treatment |
EP2111450A2 (en) | 2007-01-16 | 2009-10-28 | Yissum Research Development Company of the Hebrew University of Jerusalem | Nucleic acid constructs and methods for specific silencing of h19 |
US20090042825A1 (en) * | 2007-08-06 | 2009-02-12 | Majed Matar | Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer |
CN107049965A (en) * | 2007-08-06 | 2017-08-18 | Clsn实验室股份有限公司 | Nucleic acid lipopolymer compositions |
ES2394129T3 (en) | 2007-10-25 | 2013-01-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Constructs Containing Multiple Expression Cassettes for Cancer Therapy |
CN102202693A (en) * | 2008-09-03 | 2011-09-28 | 森尼斯科技术公司 | Use of a truncated elf-5a1 polynucleotide to induce apoptosis in cancer cells |
DE102009006606A1 (en) * | 2009-01-29 | 2010-08-05 | Philipps-Universität Marburg | Non-viral transfection agent |
SG10201909209RA (en) * | 2015-05-05 | 2019-11-28 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Nucleic acid-cationic polymer compositions and methods of making and using the same |
-
2016
- 2016-05-05 SG SG10201909209R patent/SG10201909209RA/en unknown
- 2016-05-05 MX MX2017014060A patent/MX2017014060A/en unknown
- 2016-05-05 CA CA2984879A patent/CA2984879A1/en not_active Abandoned
- 2016-05-05 SG SG11201708760PA patent/SG11201708760PA/en unknown
- 2016-05-05 KR KR1020177034664A patent/KR20180015145A/en not_active Application Discontinuation
- 2016-05-05 RU RU2017140065A patent/RU2017140065A/en not_active Application Discontinuation
- 2016-05-05 WO PCT/IL2016/050477 patent/WO2016178233A1/en active Application Filing
- 2016-05-05 AU AU2016258326A patent/AU2016258326A1/en not_active Abandoned
- 2016-05-05 EP EP16730012.8A patent/EP3291799A1/en not_active Withdrawn
- 2016-05-05 BR BR112017023788A patent/BR112017023788A2/en not_active Application Discontinuation
- 2016-05-05 US US15/571,699 patent/US20180154023A1/en not_active Abandoned
- 2016-05-05 JP JP2017556986A patent/JP2018515479A/en active Pending
- 2016-05-05 CN CN201680039770.4A patent/CN107735079A/en active Pending
-
2017
- 2017-10-25 IL IL255254A patent/IL255254A0/en unknown
- 2017-12-05 PH PH12017502216A patent/PH12017502216A1/en unknown
-
2020
- 2020-01-02 US US16/732,770 patent/US20200138977A1/en not_active Abandoned
-
2021
- 2021-05-07 JP JP2021079039A patent/JP2021130671A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200138977A1 (en) | 2020-05-07 |
JP2021130671A (en) | 2021-09-09 |
WO2016178233A1 (en) | 2016-11-10 |
CN107735079A (en) | 2018-02-23 |
PH12017502216A1 (en) | 2018-06-11 |
RU2017140065A (en) | 2019-06-05 |
EP3291799A1 (en) | 2018-03-14 |
MX2017014060A (en) | 2018-07-06 |
KR20180015145A (en) | 2018-02-12 |
JP2018515479A (en) | 2018-06-14 |
AU2016258326A1 (en) | 2017-11-23 |
US20180154023A1 (en) | 2018-06-07 |
BR112017023788A2 (en) | 2018-10-16 |
CA2984879A1 (en) | 2016-11-10 |
SG11201708760PA (en) | 2017-11-29 |
RU2017140065A3 (en) | 2019-09-27 |
IL255254A0 (en) | 2017-12-31 |
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