NO20080892L - Nye anti-IGF-IR antistoffer og anvendelse derav - Google Patents
Nye anti-IGF-IR antistoffer og anvendelse deravInfo
- Publication number
- NO20080892L NO20080892L NO20080892A NO20080892A NO20080892L NO 20080892 L NO20080892 L NO 20080892L NO 20080892 A NO20080892 A NO 20080892A NO 20080892 A NO20080892 A NO 20080892A NO 20080892 L NO20080892 L NO 20080892L
- Authority
- NO
- Norway
- Prior art keywords
- igf
- antibodies
- receptor
- igfi
- overexpression
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
SAMMENDRAG Den foreliggende oppfinnelsen angår nye antistoffer som er i stand til å binde spesifikt til den humane insulinlignende vekstfaktor 1-reseptoren (IGF-IR). Oppfinnelsen omfatter likeledes anvendelse av disse antistoffene som et medikament for profylaktisk og/eller terapeutisk behandling av kreftformer som overuttrykker IGF-IR, stimulert enten av IGFI og/eller IGF2 eller enhver patologi koblet med overekspresjon av nevnte reseptor så vel som i fremgangsmåter eller sett for diagnose av sykdommer koblet til overekspresjon av IGF-IR og/eller IGFI/insulinhybridreseptoren.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70162205P | 2005-07-22 | 2005-07-22 | |
FR0507829A FR2888850B1 (fr) | 2005-07-22 | 2005-07-22 | Nouveaux anticorps anti-igf-ir et leurs applications |
PCT/EP2006/064543 WO2007012614A2 (en) | 2005-07-22 | 2006-07-21 | Novel anti-igf-ir antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20080892L true NO20080892L (no) | 2008-04-16 |
Family
ID=36118266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20080892A NO20080892L (no) | 2005-07-22 | 2008-02-20 | Nye anti-IGF-IR antistoffer og anvendelse derav |
Country Status (20)
Country | Link |
---|---|
US (2) | US8361461B2 (no) |
EP (2) | EP1907426B1 (no) |
JP (1) | JP5185817B2 (no) |
KR (1) | KR101343928B1 (no) |
CN (1) | CN101238149B (no) |
AR (1) | AR054175A1 (no) |
AU (1) | AU2006274086B2 (no) |
BR (1) | BRPI0613642A2 (no) |
CA (1) | CA2616099C (no) |
FR (1) | FR2888850B1 (no) |
GT (1) | GT200600324A (no) |
HK (1) | HK1116201A1 (no) |
IL (1) | IL188712A (no) |
MX (1) | MX2008000964A (no) |
NO (1) | NO20080892L (no) |
NZ (1) | NZ565248A (no) |
RU (1) | RU2434882C2 (no) |
TW (1) | TWI414532B (no) |
WO (1) | WO2007012614A2 (no) |
ZA (1) | ZA200800636B (no) |
Families Citing this family (134)
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EP1622942B1 (en) | 2003-05-01 | 2014-11-19 | ImClone LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
FR2873699B1 (fr) * | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
US8128929B2 (en) | 2005-06-17 | 2012-03-06 | Imclone Llc | Antibodies against PDGFRa |
AP2008004569A0 (en) | 2006-02-03 | 2008-08-31 | Imclone Systems Inc | IGR-IR antagonists as adjuvants for treatment of prostrate cancer |
EA200802061A1 (ru) | 2006-03-28 | 2009-04-28 | Байоджен Айдек Эмэй Инк. | Антитело или его фрагмент, специфично связывающееся с рецептором 1 инсулиноподобного фактора роста (igf-r1) (варианты), композиция на его основе, полинуклеотид, кодирующий вариабельную область антитела (варианты), содержащие полинуклеотид композиция (варианты) и вектор, содержащая вектор клетка-хозяин (варианты), способ продуцирования антитела или его фрагмента (варианты) и способ лечения гиперпролиферативного заболевания у животного организма |
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