NL8900029A - Isochinoline-derivaten, hun bereiding en hun toepassing. - Google Patents

Isochinoline-derivaten, hun bereiding en hun toepassing. Download PDF

Info

Publication number
NL8900029A
NL8900029A NL8900029A NL8900029A NL8900029A NL 8900029 A NL8900029 A NL 8900029A NL 8900029 A NL8900029 A NL 8900029A NL 8900029 A NL8900029 A NL 8900029A NL 8900029 A NL8900029 A NL 8900029A
Authority
NL
Netherlands
Prior art keywords
dimethoxy
phenyl
formula
isoquinoline
acid addition
Prior art date
Application number
NL8900029A
Other languages
English (en)
Dutch (nl)
Inventor
Klaus Hasspacher
Reto Naef
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NL8900029A publication Critical patent/NL8900029A/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NL8900029A 1988-01-08 1989-01-06 Isochinoline-derivaten, hun bereiding en hun toepassing. NL8900029A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888800397A GB8800397D0 (en) 1988-01-08 1988-01-08 Improvements in/relating to organic compounds
GB8800397 1988-01-08

Publications (1)

Publication Number Publication Date
NL8900029A true NL8900029A (nl) 1989-08-01

Family

ID=10629678

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8900029A NL8900029A (nl) 1988-01-08 1989-01-06 Isochinoline-derivaten, hun bereiding en hun toepassing.

Country Status (28)

Country Link
US (1) US4980359A (sv)
JP (1) JPH0649686B2 (sv)
KR (1) KR0142686B1 (sv)
AT (1) AT394365B (sv)
AU (1) AU622429B2 (sv)
BE (1) BE1002730A3 (sv)
CA (1) CA1332944C (sv)
CH (1) CH678727A5 (sv)
DE (1) DE3900233C2 (sv)
DK (1) DK5789A (sv)
ES (1) ES2010071A6 (sv)
FI (1) FI90865C (sv)
FR (1) FR2625743B1 (sv)
GB (2) GB8800397D0 (sv)
GR (1) GR1002750B (sv)
HU (1) HU205083B (sv)
IE (1) IE61914B1 (sv)
IL (1) IL88899A (sv)
IT (1) IT1229523B (sv)
LU (1) LU87423A1 (sv)
MY (1) MY103963A (sv)
NL (1) NL8900029A (sv)
NZ (1) NZ227561A (sv)
PH (1) PH25640A (sv)
PL (1) PL156099B1 (sv)
PT (1) PT89405B (sv)
SE (1) SE501548C2 (sv)
ZA (1) ZA89133B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723674A (en) * 1951-11-28 1955-11-15 Charles E Harris Telephone cableman's tent
US3007541A (en) * 1959-02-24 1961-11-07 Jr John B Mast Temporary covering and support structure therefor
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
KR930703259A (ko) * 1990-12-17 1993-11-29 알베르투스 빌헬무스 요아네스 쩨스트라텐 살균성 이소퀴놀린 유도체
CA2093577C (en) * 1992-05-07 2006-01-03 Michael Klaus Alkyl or alkoxy substituted s-heterocyclic retinoids
US5350423A (en) * 1992-09-23 1994-09-27 Burlington Industries Inc. Fabric finishing procedure
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
PL194312B1 (pl) * 1994-12-23 2007-05-31 Smithkline Beecham Corp Przeciwciało monoklonalne neutralizujące gryzoni,linia hybrydoma, humanizowane przeciwciało, region CDR ciężkiego łańcucha immunoglobuliny, region CDR lekkiego łańcucha immunoglobuliny, cząsteczki kwasu nukleinowego, przeciwciało chimeryczne, kompozycja farmaceutyczna, izolowana sekwencja kwasu nukleinowego, rekombinowany plazmid i komórka gospodarza oraz sposób wytwarzania humanizowanego przeciwciała i sposób wspomagania diagnostyki alergii
US5683892A (en) * 1994-12-23 1997-11-04 Smithkline Beecham Corporation DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5783184A (en) * 1994-12-23 1998-07-21 Smithkline Beecham Corporation Method for treatment and diagnosis of IL-5 mediated disorders
US7399837B2 (en) * 1995-12-22 2008-07-15 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
IT1296985B1 (it) 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
EP1163226B1 (en) * 1999-01-15 2007-03-14 ALTANA Pharma AG Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
EP2193808A1 (en) 1999-08-21 2010-06-09 Nycomed GmbH Synergistic combination
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
EP2152310A4 (en) * 2007-04-30 2010-05-26 Glaxosmithkline Llc METHODS OF ADMINISTERING ANTI-IL-5 ANTIBODIES
BRPI0910854A2 (pt) * 2008-03-28 2015-10-06 Glaxosmithkline Llc métodos de tratamento
WO2010045342A1 (en) 2008-10-17 2010-04-22 Wisconsin Alumni Research Foundation Method of making biologically active alpha-beta peptides
JP7295038B2 (ja) 2017-06-06 2023-06-20 グラクソスミスクライン エルエルシー 小児患者のための生物薬剤組成物及び方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB645139A (en) * 1946-10-22 1950-10-25 Servita Gyogyszeryar Es Vegyip Improved process for the production of isoquinoline derivatives
DE1184344B (de) * 1962-06-16 1964-12-31 Orgamol Sa Verfahren zur Herstellung von Isochinolinderivaten
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
DE2401453A1 (de) * 1973-01-16 1974-07-18 John James Voorhees Pharmazeutische zusammensetzung zur behandlung von hautproliferationserkrankungen
US4018927A (en) * 1973-12-17 1977-04-19 The Regents Of The University Of Michigan Treatment of proliferating skin diseases with papaverine alkaloids
SE7500859L (sv) * 1974-02-05 1975-08-06 Sandoz Ag
DE2811361A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinaldehyde und verfahren zu ihrer herstellung
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
PH25651A (en) * 1986-05-21 1991-08-21 Duphar Int Res New di, tetrahydroisoquinoline derivatives

Also Published As

Publication number Publication date
AT394365B (de) 1992-03-25
IT1229523B (it) 1991-09-04
SE8900039L (sv) 1989-07-09
FI90865C (sv) 1994-04-11
CH678727A5 (sv) 1991-10-31
CA1332944C (en) 1994-11-08
PT89405B (pt) 1993-09-30
LU87423A1 (fr) 1989-08-30
PL156099B1 (pl) 1992-02-28
SE8900039D0 (sv) 1989-01-05
JPH01213267A (ja) 1989-08-28
MY103963A (en) 1993-10-30
NZ227561A (en) 1991-11-26
FR2625743B1 (fr) 1990-11-09
GR1002750B (el) 1997-08-26
JPH0649686B2 (ja) 1994-06-29
PT89405A (pt) 1990-02-08
IE61914B1 (en) 1994-11-30
ES2010071A6 (es) 1989-10-16
GR890100008A (el) 1994-03-31
FI90865B (sv) 1993-12-31
DK5789D0 (da) 1989-01-06
GB8800397D0 (en) 1988-02-10
US4980359A (en) 1990-12-25
HU205083B (en) 1992-03-30
DE3900233C2 (de) 2000-04-27
BE1002730A3 (fr) 1991-05-21
ZA89133B (en) 1990-09-26
SE501548C2 (sv) 1995-03-13
IL88899A0 (en) 1989-08-15
GB8900102D0 (en) 1989-03-01
GB2213482B (en) 1991-09-11
DE3900233A1 (de) 1989-07-20
FI890072A0 (sv) 1989-01-06
FI890072A (sv) 1989-07-09
DK5789A (da) 1989-07-09
AU2779589A (en) 1989-07-20
GB2213482A (en) 1989-08-16
KR0142686B1 (ko) 1998-07-15
IL88899A (en) 1994-07-31
KR890011851A (ko) 1989-08-22
HUT52061A (en) 1990-06-28
PH25640A (en) 1991-08-21
ATA3589A (de) 1991-09-15
IT8947504A0 (it) 1989-01-04
PL277092A1 (en) 1989-09-04
FR2625743A1 (fr) 1989-07-13
IE890037L (en) 1989-07-08
AU622429B2 (en) 1992-04-09

Similar Documents

Publication Publication Date Title
NL8900029A (nl) Isochinoline-derivaten, hun bereiding en hun toepassing.
RU2060992C1 (ru) Производные дигидроизохинолинов и способ их получения
DK169337B1 (da) Xanthinforbindelser, farmaceutisk præparat indeholdende disse, xanthinforbindelser til anvendelse som et farmaceutisk middel samt fremgangsmåde til fremstilling af forbindelserne
EP1709047B1 (en) Azabenzofuran substituted thioureas as inhibitors of viral replication
SU1395140A3 (ru) Способ получени карбостирильных производных
SK283215B6 (sk) Benzopyrány, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie
US20130231366A1 (en) Use of a Novel Alpha-7 Nachr Antagonist to Suppress Pathogenic Signal Transduction in Cancer and Aids
CZ292205B6 (cs) Deriváty xanthinu k přípravě léčiva k léčení a profylaxi šokových onemocnění, nové deriváty xanthinu a způsob jejich přípravy
JP4216337B2 (ja) ベンゾ[g]キノリン誘導体
EP0247971A2 (en) Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
US20040038966A1 (en) Cyclic amine derivatives and use thereof
JP2625094B2 (ja) 抗血小板・抗血栓剤
JPH0534354B2 (sv)
RO109541B1 (ro) Derivați de dihidro-izochinolină, procedee de obținere și compoziții farmaceutice

Legal Events

Date Code Title Description
BV The patent application has lapsed
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: NOVARTIS AG

BV The patent application has lapsed