NL8002603A - Werkwijze voor de enzymatische bereiding van l-tryptofaan. - Google Patents
Werkwijze voor de enzymatische bereiding van l-tryptofaan. Download PDFInfo
- Publication number
- NL8002603A NL8002603A NL8002603A NL8002603A NL8002603A NL 8002603 A NL8002603 A NL 8002603A NL 8002603 A NL8002603 A NL 8002603A NL 8002603 A NL8002603 A NL 8002603A NL 8002603 A NL8002603 A NL 8002603A
- Authority
- NL
- Netherlands
- Prior art keywords
- serine
- tryptophan
- reaction
- racemase
- tryptophanase
- Prior art date
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title claims description 128
- 238000000034 method Methods 0.000 title claims description 85
- 229960004799 tryptophan Drugs 0.000 title claims description 67
- 238000002360 preparation method Methods 0.000 title claims description 16
- 230000002255 enzymatic effect Effects 0.000 title claims description 7
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 108
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 86
- 229960001153 serine Drugs 0.000 claims description 76
- 238000006243 chemical reaction Methods 0.000 claims description 55
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 54
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims description 40
- 229930195711 D-Serine Natural products 0.000 claims description 39
- 102100040653 Tryptophan 2,3-dioxygenase Human genes 0.000 claims description 35
- 101710136122 Tryptophan 2,3-dioxygenase Proteins 0.000 claims description 35
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- 108010075344 Tryptophan synthase Proteins 0.000 claims description 33
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- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 12
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/227—Tryptophan
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5564579 | 1979-05-09 | ||
| JP5564579A JPS55148095A (en) | 1979-05-09 | 1979-05-09 | Enzymatic preparation of l-tryptophan |
| JP7961979A JPS565098A (en) | 1979-06-26 | 1979-06-26 | Production of l-triptophane by use of enzyme |
| JP7961979 | 1979-06-26 | ||
| JP3619780A JPS56134992A (en) | 1980-03-24 | 1980-03-24 | Suppressing method of decomposition of serine |
| JP3619780 | 1980-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8002603A true NL8002603A (nl) | 1980-11-11 |
Family
ID=27289013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8002603A NL8002603A (nl) | 1979-05-09 | 1980-05-07 | Werkwijze voor de enzymatische bereiding van l-tryptofaan. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4335209A (OSRAM) |
| AU (1) | AU530435B2 (OSRAM) |
| CA (1) | CA1128443A (OSRAM) |
| CH (1) | CH642947A5 (OSRAM) |
| DE (1) | DE3017861C2 (OSRAM) |
| FR (1) | FR2456140A1 (OSRAM) |
| GB (1) | GB2048266B (OSRAM) |
| IT (1) | IT1145337B (OSRAM) |
| MX (1) | MX6037E (OSRAM) |
| NL (1) | NL8002603A (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3123937C2 (de) * | 1980-06-17 | 1984-06-07 | Asahi Kasei Kogyo K.K., Osaka | Verfahren zur Herstellung von L-Tryptophan oder seiner Derivate |
| DE3134901A1 (de) * | 1981-08-31 | 1983-03-17 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur extraktion von aromatischen aminosaeuren aus waessriger phase |
| US4600692A (en) * | 1983-02-10 | 1986-07-15 | Purification Engineering, Inc. | Immobilized cells for preparing phenylalanine |
| US4710467A (en) * | 1983-07-29 | 1987-12-01 | Purification Engineering, Inc. | Process for preparing phenylalanine |
| EP0217862A4 (en) * | 1985-03-18 | 1989-12-28 | Genex Corp | IN VITRO SYNTHESIS PROCEDURE OF L-TRYPTOPHANE. |
| JPS62205781A (ja) * | 1986-03-03 | 1987-09-10 | Res Assoc Util Of Light Oil | シユ−ドモナス属菌株の培養方法 |
| DE3630878C1 (en) * | 1986-09-11 | 1988-03-10 | Amino Gmbh | Process for the preparation of L-tryptophan and DL-serine |
| EP0299715A3 (en) * | 1987-07-13 | 1990-07-04 | MITSUI TOATSU CHEMICALS, Inc. | Process for preparing L-tryptophan |
| US5525501A (en) * | 1990-09-14 | 1996-06-11 | Takeda Chemical Industries, Ltd. | DNA Fragment encoding acylamino acid racemase |
| US5629202A (en) * | 1994-07-19 | 1997-05-13 | Development Center For Biotechnology | Computer-controlled bioreactor system for enzymatic synthesis of L-tryptophan |
| JPH1142097A (ja) * | 1997-01-09 | 1999-02-16 | Daicel Chem Ind Ltd | Ｄ−トリプトファンの製造方法 |
| PL364984A1 (en) * | 1999-01-19 | 2004-12-27 | The Johns Hopkins University School Of Medicine | Mammalian serine racemase |
| US6984484B1 (en) | 1999-01-19 | 2006-01-10 | The Johns Hopkins University | Mammalian serine racemase |
| JP2001245689A (ja) | 2000-03-09 | 2001-09-11 | Ajinomoto Co Inc | ハロ−ｌ−トリプトファンの製造法 |
| EP1870454B1 (en) * | 2005-03-18 | 2009-12-09 | Kyowa Hakko Bio Co., Ltd. | Process for producing dipeptides |
| CA3061340A1 (en) | 2017-04-25 | 2018-11-01 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
| CN110878029A (zh) * | 2019-11-13 | 2020-03-13 | 上海星酶生物科技有限公司 | 一种d-丝氨酸的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT989051B (it) * | 1971-04-23 | 1975-05-20 | Snam Progetti | Procedimento per la produzione enzimatica di l triptofano |
| JPS5137353B2 (OSRAM) * | 1973-12-29 | 1976-10-15 | ||
| JPS51121597A (en) * | 1975-04-11 | 1976-10-23 | Ajinomoto Co Inc | Process for producing tryptophan and its derivatives |
-
1980
- 1980-04-22 GB GB8013152A patent/GB2048266B/en not_active Expired
- 1980-04-25 CA CA350,695A patent/CA1128443A/en not_active Expired
- 1980-04-25 US US06/145,267 patent/US4335209A/en not_active Expired - Lifetime
- 1980-04-30 CH CH332780A patent/CH642947A5/fr not_active IP Right Cessation
- 1980-05-01 AU AU57979/80A patent/AU530435B2/en not_active Ceased
- 1980-05-07 NL NL8002603A patent/NL8002603A/nl not_active Application Discontinuation
- 1980-05-07 IT IT48605/80A patent/IT1145337B/it active
- 1980-05-08 FR FR8010249A patent/FR2456140A1/fr active Granted
- 1980-05-09 MX MX808806U patent/MX6037E/es unknown
- 1980-05-09 DE DE3017861A patent/DE3017861C2/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2048266B (en) | 1983-11-30 |
| AU530435B2 (en) | 1983-07-14 |
| DE3017861A1 (de) | 1981-01-22 |
| IT1145337B (it) | 1986-11-05 |
| US4335209A (en) | 1982-06-15 |
| CA1128443A (en) | 1982-07-27 |
| FR2456140A1 (fr) | 1980-12-05 |
| IT8048605A0 (it) | 1980-05-07 |
| CH642947A5 (fr) | 1984-05-15 |
| GB2048266A (en) | 1980-12-10 |
| DE3017861C2 (de) | 1984-11-22 |
| AU5797980A (en) | 1980-11-13 |
| MX6037E (es) | 1984-10-08 |
| FR2456140B1 (OSRAM) | 1984-10-26 |
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| Date | Code | Title | Description |
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| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |