NL192112C - Werkwijze voor de bereiding van aspartaam. - Google Patents

Werkwijze voor de bereiding van aspartaam. Download PDF

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Publication number
NL192112C
NL192112C NL8401674A NL8401674A NL192112C NL 192112 C NL192112 C NL 192112C NL 8401674 A NL8401674 A NL 8401674A NL 8401674 A NL8401674 A NL 8401674A NL 192112 C NL192112 C NL 192112C
Authority
NL
Netherlands
Prior art keywords
methyl ester
aspartyl
phenylalanine methyl
phosphoric acid
phosphate
Prior art date
Application number
NL8401674A
Other languages
English (en)
Dutch (nl)
Other versions
NL8401674A (nl
NL192112B (nl
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of NL8401674A publication Critical patent/NL8401674A/nl
Publication of NL192112B publication Critical patent/NL192112B/xx
Application granted granted Critical
Publication of NL192112C publication Critical patent/NL192112C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NL8401674A 1983-05-31 1984-05-25 Werkwijze voor de bereiding van aspartaam. NL192112C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838314907A GB8314907D0 (en) 1983-05-31 1983-05-31 Aspartame synthesis
GB8314907 1983-05-31

Publications (3)

Publication Number Publication Date
NL8401674A NL8401674A (nl) 1984-12-17
NL192112B NL192112B (nl) 1996-10-01
NL192112C true NL192112C (nl) 1997-02-04

Family

ID=10543585

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8401674A NL192112C (nl) 1983-05-31 1984-05-25 Werkwijze voor de bereiding van aspartaam.

Country Status (29)

Country Link
US (1) US4656304A (el)
JP (1) JPS59227850A (el)
KR (1) KR910002387B1 (el)
AT (1) AT387024B (el)
AU (1) AU561593B2 (el)
BE (1) BE899783A (el)
CA (1) CA1244008A (el)
CH (1) CH659061A5 (el)
CS (1) CS257778B2 (el)
DE (1) DE3419921A1 (el)
DK (1) DK163928C (el)
ES (1) ES8506598A1 (el)
FI (1) FI80465C (el)
FR (1) FR2547816B1 (el)
GB (1) GB8314907D0 (el)
GR (1) GR82034B (el)
HU (1) HU191146B (el)
IE (2) IE810577L (el)
IL (1) IL71930A (el)
IT (1) IT1212097B (el)
NL (1) NL192112C (el)
NO (1) NO163738C (el)
NZ (1) NZ208279A (el)
PH (1) PH21764A (el)
PT (1) PT78657B (el)
SE (1) SE459176B (el)
SU (1) SU1342423A3 (el)
YU (1) YU44456B (el)
ZA (1) ZA844071B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
JP2662287B2 (ja) * 1988-03-14 1997-10-08 三井東圧化学株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの分離方法
US5283357A (en) * 1988-03-14 1994-02-01 Mitsui Toatsu Chemicals, Incorporated Separation method of α-l-aspartyl-l-phenylalanine methyl ester
US5017690A (en) * 1989-08-11 1991-05-21 W. R. Grace & Co.-Conn. Deblocking N-formyl aspartame compounds
NL9201408A (nl) * 1992-08-05 1994-03-01 Holland Sweetener Co Werkwijze voor het kristalliseren van aspartaam.
BE1010071A3 (nl) * 1996-04-10 1997-12-02 Holland Sweetener Co Aspartaam op drager.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492131A (en) * 1966-04-18 1970-01-27 Searle & Co Peptide sweetening agents
JPS5140069B1 (el) * 1971-07-09 1976-11-01
US3833553A (en) * 1970-01-31 1974-09-03 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine alkyl esters
BE791544A (fr) * 1971-11-19 1973-05-17 Stamicarbon Preparation d'esters alkyliques de dipeptide
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
US4173562A (en) * 1976-12-27 1979-11-06 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
JPS57131746A (en) * 1981-02-10 1982-08-14 Ajinomoto Co Inc Removal of n-formyl group
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法

Also Published As

Publication number Publication date
KR910002387B1 (ko) 1991-04-20
GB8314907D0 (en) 1983-07-06
HU191146B (en) 1987-01-28
NO842129L (no) 1984-12-03
CS399884A2 (en) 1987-11-12
IE810577L (en) 1982-09-16
IE841312L (en) 1984-11-30
DK163928B (da) 1992-04-21
ES532916A0 (es) 1985-08-01
NO163738B (no) 1990-04-02
GR82034B (el) 1984-12-12
FI80465C (fi) 1990-06-11
DE3419921A1 (de) 1984-12-13
JPS59227850A (ja) 1984-12-21
IL71930A (en) 1986-12-31
IL71930A0 (en) 1984-09-30
FI80465B (fi) 1990-02-28
FR2547816A1 (fr) 1984-12-28
JPH0570638B2 (el) 1993-10-05
NZ208279A (en) 1987-04-30
YU44456B (en) 1990-08-31
NL8401674A (nl) 1984-12-17
AT387024B (de) 1988-11-25
US4656304A (en) 1987-04-07
FI841952A0 (fi) 1984-05-15
PT78657A (en) 1984-06-01
SE8402953L (sv) 1984-12-01
SU1342423A3 (ru) 1987-09-30
IT8421147A0 (it) 1984-05-29
DK163928C (da) 1992-09-14
IT1212097B (it) 1989-11-08
CS257778B2 (en) 1988-06-15
PT78657B (en) 1986-09-08
AU561593B2 (en) 1987-05-14
AU2876784A (en) 1984-12-06
YU92284A (en) 1986-10-31
HUT34434A (en) 1985-03-28
DE3419921C2 (el) 1989-04-20
SE459176B (sv) 1989-06-12
FR2547816B1 (fr) 1987-10-30
ES8506598A1 (es) 1985-08-01
KR850000030A (ko) 1985-02-25
ZA844071B (en) 1984-12-24
FI841952A (fi) 1984-12-01
SE8402953D0 (sv) 1984-05-30
DK270084A (da) 1984-12-01
IE57662B1 (en) 1993-02-24
DK270084D0 (da) 1984-05-30
NL192112B (nl) 1996-10-01
PH21764A (en) 1988-02-18
ATA172384A (de) 1988-04-15
BE899783A (fr) 1984-09-17
CA1244008A (en) 1988-11-01
NO163738C (no) 1990-07-11
CH659061A5 (it) 1986-12-31

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BK Erratum

Free format text: PAT.BUL.04/97,HEADING P,SECTION 2 PAGE 494:THE TITLE OF THE INVENTION SHOULD READ:WERKWIJZE VOOR DEBEREIDING VAN DE A-L-ASPARTYL-L-FENYLALANINE-METHYLESTER

V1 Lapsed because of non-payment of the annual fee

Effective date: 19971201