NI201400005A - Indazoles - Google Patents

Indazoles

Info

Publication number
NI201400005A
NI201400005A NI201400005A NI201400005A NI201400005A NI 201400005 A NI201400005 A NI 201400005A NI 201400005 A NI201400005 A NI 201400005A NI 201400005 A NI201400005 A NI 201400005A NI 201400005 A NI201400005 A NI 201400005A
Authority
NI
Nicaragua
Prior art keywords
compounds
pharmaceutically acceptable
indazoles
salts
copd
Prior art date
Application number
NI201400005A
Other languages
English (en)
Inventor
Wadsworth Coe Jotham
Martin Dehnhardt Christoph
Jones Peter
Wade Kortum Steven
Anil Sabnis Yogesh
Michel Wakenhut Florian
Alistair Whitlock Gavin
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46826868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI201400005(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of NI201400005A publication Critical patent/NI201400005A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

La presente invención se refiere a los compuestos de fórmula (I): a sales farmacéuticamente aceptables y a un solvato farmacéuticamente aceptables de dichos compuestos y sales, donde los sustituyentes se definen en la presente; a composiciones que contienen tales compuestos; y a los usos de tales compuestos en el tratamiento de varias enfermedades, en particular asma y COPD.
NI201400005A 2011-07-27 2014-01-24 Indazoles NI201400005A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161512144P 2011-07-27 2011-07-27

Publications (1)

Publication Number Publication Date
NI201400005A true NI201400005A (es) 2014-04-23

Family

ID=46826868

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201400005A NI201400005A (es) 2011-07-27 2014-01-24 Indazoles

Country Status (29)

Country Link
US (2) US8575336B2 (es)
EP (1) EP2736907B1 (es)
JP (1) JP5579351B1 (es)
KR (1) KR20140026627A (es)
CN (1) CN103717599B (es)
AP (1) AP2014007372A0 (es)
AR (1) AR087348A1 (es)
AU (1) AU2012288491A1 (es)
BR (1) BR112014001801A2 (es)
CA (1) CA2841882A1 (es)
CL (1) CL2014000122A1 (es)
CO (1) CO6862160A2 (es)
CR (1) CR20140042A (es)
CU (1) CU20140009A7 (es)
DO (1) DOP2014000016A (es)
EA (1) EA201490357A1 (es)
EC (1) ECSP14013222A (es)
GT (1) GT201400016A (es)
IL (1) IL230662A0 (es)
MA (1) MA35285B1 (es)
MD (1) MD20140002A2 (es)
MX (1) MX2014001004A (es)
NI (1) NI201400005A (es)
PE (1) PE20141059A1 (es)
TN (1) TN2014000033A1 (es)
TW (1) TWI462922B (es)
UA (1) UA108442C2 (es)
UY (1) UY34220A (es)
WO (1) WO2013014567A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
WO2015173683A1 (en) 2014-05-14 2015-11-19 Pfizer Inc. Pyrazolopyridines and pyrazolopyrimidines
JP2018507236A (ja) 2015-03-04 2018-03-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ トリアゾロピリジン化合物及びその使用法
EP3286181B1 (en) 2015-04-22 2021-01-27 Rigel Pharmaceuticals, Inc. Pyrazole compounds and method for making and using the compounds
EP3865481A1 (en) 2015-11-03 2021-08-18 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
EP3371185B1 (en) 2015-11-03 2020-09-30 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
US10100049B2 (en) * 2015-11-03 2018-10-16 Theravance Biopharma R&D Ip, Llc JAK kinase inhibitor compounds for treatment of respiratory disease
TW201720828A (zh) 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
US20170157215A1 (en) 2015-12-04 2017-06-08 Jomoco, Corp. Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates
JP6936236B2 (ja) 2016-02-18 2021-09-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 治療化合物、組成物及びその方法の使用
EP3452464B1 (en) 2016-05-05 2021-12-15 F. Hoffmann-La Roche AG Pyrazole derivatives, compositions and therapeutic use thereof
JP7004677B2 (ja) * 2016-06-01 2022-01-21 バイエル・アニマル・ヘルス・ゲーエムベーハー 動物におけるアレルギー性および／または炎症性疾患の治療および予防に有用な置換インダゾール
BR112019004486A2 (pt) 2016-09-06 2019-05-28 Hoffmann La Roche compostos de 8-(azetidin-1-il)-[1,2,4] triazolo [1,5a] piridinil, composições e métodos de uso dos mesmos
BR112019013287A2 (pt) 2016-12-29 2019-12-24 Hoffmann La Roche compostos de pirazolopirimidina e métodos de uso dos mesmos
ES2882186T3 (es) * 2017-03-09 2021-12-01 Theravance Biopharma R&D Ip Llc Inhibidores de JAK que contienen una amida heterocíclica de 4 miembros
WO2018166993A2 (en) 2017-03-14 2018-09-20 F. Hoffmann-La Roche Ag Pyrazolochlorophenyl compounds, compositions and methods of use thereof
AU2018261591B2 (en) * 2017-05-01 2021-09-02 Theravance Biopharma R&D Ip, Llc Crystalline forms of a JAK inhibitor compound
AU2018261588A1 (en) 2017-05-01 2019-10-31 Theravance Biopharma R&D Ip, Llc Methods of treatment using a JAK inhibitor compound
AR111495A1 (es) * 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
MX2019013308A (es) 2017-05-22 2020-02-12 Hoffmann La Roche Composiciones y compuestos terapeuticos, y metodos para su uso.
JP7228318B6 (ja) 2017-05-22 2023-03-10 エフ． ホフマン－ラ ロシュ アーゲー 処置用化合物及び組成物、並びにその使用方法
EP3740488A1 (en) 2018-01-15 2020-11-25 F. Hoffmann-La Roche AG Pyrazolopyrimidine compounds as jak inhibitors
SG11202101785UA (en) * 2018-09-04 2021-03-30 Theravance Biopharma R&D Ip Llc Process for preparing jak inhibitors and intermediates thereof
PL3837258T3 (pl) * 2018-09-04 2024-09-16 Theravance Biopharma R&D Ip, Llc Amidy dimetyloaminoazetydyny jako inhibitory jak
BR112021004063A2 (pt) * 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc amidas heterocíclicas com 5 a 7 membros como inibidores de jak
EP3853229A1 (en) 2018-10-29 2021-07-28 Theravance Biopharma R&D IP, LLC 2-azabicyclo hexane compound as jak inhibitor
PT3932919T (pt) * 2019-02-25 2024-07-30 Henan Medinno Pharmaceutical Tech Co Ltd Composto inibidor de jak e sua utilização
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
CN114075199A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
CA3140024A1 (en) 2019-06-18 2020-12-24 Mark Edward Zak Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof
EP3986900A1 (en) 2019-06-18 2022-04-27 F. Hoffmann-La Roche AG Tetrazole-substituted pyrazolopyrimidine inhibitors of jak kinases and uses thereof
JP2022537354A (ja) 2019-06-18 2022-08-25 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｊａｋキナーゼのピラゾロピリミジンアリールエーテル阻害剤及びその使用
EP4003990A1 (en) 2019-08-30 2022-06-01 Rigel Pharmaceuticals, Inc. Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations
EP4071145A4 (en) * 2019-12-30 2023-04-19 Liang Lu JAK INHIBITOR COMPOUND AND ITS USE
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
TW202144346A (zh) * 2020-03-18 2021-12-01 四川海思科製藥有限公司 一種吲唑衍生物及其在醫藥上的應用
CN117813298A (zh) * 2021-06-25 2024-04-02 施万生物制药研发Ip有限责任公司 作为jak抑制剂的咪唑吲唑化合物
CN117343063A (zh) * 2022-07-04 2024-01-05 河南迈英诺医药科技有限公司 作为trk抑制剂和/或ret抑制剂的化合物及其用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
AU3956900A (en) 1999-04-16 2000-11-02 Boehringer Ingelheim International Gmbh Substituted imidazoles, their preparation and use
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
AU2004238508B2 (en) 2003-05-13 2009-11-19 F. Hoffmann-La Roche Ag Imidazo-benzothiazoles
US7884109B2 (en) * 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
ATE455103T1 (de) 2005-06-24 2010-01-15 Bristol Myers Squibb Co Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate
US8648069B2 (en) * 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
JP5580332B2 (ja) * 2008-12-18 2014-08-27 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害剤として活性な置換インダゾール誘導体
US8642324B2 (en) 2009-02-05 2014-02-04 Low Impact Limited Continuous flow worm farm
KR101127161B1 (ko) * 2009-07-13 2012-03-20 한국화학연구원 테트라히드로이미다조피리딘기가 치환된 퀴놀리논 화합물
ES2556350T3 (es) * 2009-08-10 2016-01-15 Samumed, Llc Inhibidores de indazol de la vía de señalización de Wnt y sus usos terapéuticos
CN102595899A (zh) * 2009-08-10 2012-07-18 埃皮瑟瑞克斯有限公司 作为wnt/b-联蛋白信号传导途径抑制剂的吲唑及其治疗用途
AR078012A1 (es) * 2009-09-01 2011-10-05 Incyte Corp Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles

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