MD20150048A2 - Derivaţi ai pirolotriazinonei în calitate de inhibitori ai PI3K - Google Patents

Derivaţi ai pirolotriazinonei în calitate de inhibitori ai PI3K Download PDF

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Publication number
MD20150048A2
MD20150048A2 MDA20150048A MD20150048A MD20150048A2 MD 20150048 A2 MD20150048 A2 MD 20150048A2 MD A20150048 A MDA20150048 A MD A20150048A MD 20150048 A MD20150048 A MD 20150048A MD 20150048 A2 MD20150048 A2 MD 20150048A2
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MD
Moldova
Prior art keywords
pi3k inhibitors
pyrrolotriazinone derivatives
pyrrolotriazinone
derivatives
relates
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MDA20150048A
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English (en)
Russian (ru)
Inventor
Сола Монтсеррат Эрра
ПЬЕРА Марта КАРРАСКАЛЬ
Моль Хоан Тальтавуль
ХАВАЛОЙЕС Хуан Франсиско0 КАТУРЛА
АНЧУЭЛА Франсиско Хавьер0 БЕРНАЛЬ
САНТАКАНА Льюйс Микель ПАХЕС
Сепеда Марта Мир
КОЛЬ Гаспар КАСАЛЬС
ОЛАСАГАРРЕ Мария Бегонь0 ЭРНАНДЕС
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Almirall S.A.
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Publication of MD20150048A2 publication Critical patent/MD20150048A2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Invenţia se referă la derivaţi noi ai pirolotriazinonei, care au structura chimică conform formulei (I):(I)De asemenea, invenţia se referă la procedeul de preparare a lor, la compoziţii farmaceutice care îi conţin şi la utilizarea acestor derivaţi în terapie în calitate de inhibitori ai fosfoinozitida 3-kinazelor (PI3K).
MDA20150048A 2012-10-16 2013-10-15 Derivaţi ai pirolotriazinonei în calitate de inhibitori ai PI3K MD20150048A2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12382399 2012-10-16
US201261718782P 2012-10-26 2012-10-26
PCT/EP2013/071551 WO2014060432A1 (en) 2012-10-16 2013-10-15 Pyrrolotriazinone derivatives as pi3k inhibitors

Publications (1)

Publication Number Publication Date
MD20150048A2 true MD20150048A2 (ro) 2015-10-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20150048A MD20150048A2 (ro) 2012-10-16 2013-10-15 Derivaţi ai pirolotriazinonei în calitate de inhibitori ai PI3K

Country Status (29)

Country Link
US (1) US9388189B2 (ro)
EP (1) EP2909207A1 (ro)
JP (1) JP2015533181A (ro)
KR (1) KR20150068953A (ro)
CN (1) CN104854108A (ro)
AP (1) AP2015008328A0 (ro)
AR (1) AR093036A1 (ro)
AU (1) AU2013333938A1 (ro)
BR (1) BR112015007231A2 (ro)
CA (1) CA2883426A1 (ro)
CL (1) CL2015000956A1 (ro)
CR (1) CR20150175A (ro)
DO (1) DOP2015000077A (ro)
EA (1) EA027277B1 (ro)
GE (1) GEP201706623B (ro)
GT (1) GT201500094A (ro)
HK (1) HK1211027A1 (ro)
IL (1) IL237475A0 (ro)
MD (1) MD20150048A2 (ro)
MX (1) MX2015004327A (ro)
NI (1) NI201500054A (ro)
PE (1) PE20150637A1 (ro)
PH (1) PH12015500813A1 (ro)
SG (1) SG11201502032VA (ro)
TN (1) TN2015000112A1 (ro)
TW (1) TW201429975A (ro)
UY (1) UY35086A (ro)
WO (1) WO2014060432A1 (ro)
ZA (1) ZA201501220B (ro)

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CA2883426A1 (en) 2014-04-24
AR093036A1 (es) 2015-05-13
GT201500094A (es) 2017-08-01
TN2015000112A1 (en) 2016-06-29
CL2015000956A1 (es) 2015-06-19
US20150291595A1 (en) 2015-10-15
MX2015004327A (es) 2015-06-10
IL237475A0 (en) 2015-04-30
NI201500054A (es) 2016-02-01
EA027277B1 (ru) 2017-07-31
TW201429975A (zh) 2014-08-01
SG11201502032VA (en) 2015-05-28
DOP2015000077A (es) 2015-04-30
AU2013333938A1 (en) 2015-04-09
EA201500426A1 (ru) 2015-10-30
CR20150175A (es) 2015-05-11
WO2014060432A1 (en) 2014-04-24
GEP201706623B (en) 2017-02-10
BR112015007231A2 (pt) 2017-07-04
HK1211027A1 (en) 2016-05-13
PH12015500813B1 (en) 2015-06-08
EP2909207A1 (en) 2015-08-26
KR20150068953A (ko) 2015-06-22
JP2015533181A (ja) 2015-11-19
CN104854108A (zh) 2015-08-19
ZA201501220B (en) 2017-04-26
US9388189B2 (en) 2016-07-12
PH12015500813A1 (en) 2015-06-08
UY35086A (es) 2014-05-30
PE20150637A1 (es) 2015-05-08
AP2015008328A0 (en) 2015-03-31

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