CR20140042A - Indazoles - Google Patents

Indazoles

Info

Publication number
CR20140042A
CR20140042A CR20140042A CR20140042A CR20140042A CR 20140042 A CR20140042 A CR 20140042A CR 20140042 A CR20140042 A CR 20140042A CR 20140042 A CR20140042 A CR 20140042A CR 20140042 A CR20140042 A CR 20140042A
Authority
CR
Costa Rica
Prior art keywords
indazoles
compounds
formula
relates
present
Prior art date
Application number
CR20140042A
Other languages
English (en)
Inventor
Jotham Wadsworth Coe
Christoph Martin Dehnhardt
Peter Jones
Steven Wade Kortum
Yogesh Anil Sabnis
Florian Michel Wakenhut
Gavin Alistair Whitlock
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46826868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140042(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of CR20140042A publication Critical patent/CR20140042A/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención se refiere a los compuestos de fórmula (I):
CR20140042A 2011-07-27 2014-01-27 Indazoles CR20140042A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161512144P 2011-07-27 2011-07-27

Publications (1)

Publication Number Publication Date
CR20140042A true CR20140042A (es) 2014-03-19

Family

ID=46826868

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140042A CR20140042A (es) 2011-07-27 2014-01-27 Indazoles

Country Status (29)

Country Link
US (2) US8575336B2 (es)
EP (1) EP2736907B1 (es)
JP (1) JP5579351B1 (es)
KR (1) KR20140026627A (es)
CN (1) CN103717599B (es)
AP (1) AP2014007372A0 (es)
AR (1) AR087348A1 (es)
AU (1) AU2012288491A1 (es)
BR (1) BR112014001801A2 (es)
CA (1) CA2841882A1 (es)
CL (1) CL2014000122A1 (es)
CO (1) CO6862160A2 (es)
CR (1) CR20140042A (es)
CU (1) CU20140009A7 (es)
DO (1) DOP2014000016A (es)
EA (1) EA201490357A1 (es)
EC (1) ECSP14013222A (es)
GT (1) GT201400016A (es)
IL (1) IL230662A0 (es)
MA (1) MA35285B1 (es)
MD (1) MD20140002A2 (es)
MX (1) MX2014001004A (es)
NI (1) NI201400005A (es)
PE (1) PE20141059A1 (es)
TN (1) TN2014000033A1 (es)
TW (1) TWI462922B (es)
UA (1) UA108442C2 (es)
UY (1) UY34220A (es)
WO (1) WO2013014567A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
MD20160121A2 (ro) 2014-05-14 2017-05-31 Pfizer Inc. Pirazolopiridine şi pirazolopirimidine
WO2016139212A1 (en) 2015-03-04 2016-09-09 F. Hoffmann-La Roche Ag Triazolopyridine compounds and methods of use thereof
MX2017013413A (es) 2015-04-22 2018-06-06 Rigel Pharmaceuticals Inc Compuestos de pirazol y metodo para elaborar y usar los compuestos.
EP3712152B1 (en) 2015-11-03 2021-01-13 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
PT3371185T (pt) 2015-11-03 2020-12-28 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
CN108349972B (zh) * 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
TW201720828A (zh) 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
US20170157215A1 (en) 2015-12-04 2017-06-08 Jomoco, Corp. Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates
EP3416967B1 (en) 2016-02-18 2022-02-09 F. Hoffmann-La Roche AG Therapeutic compounds, compositions and methods of use thereof
JP7034942B2 (ja) 2016-05-05 2022-03-14 エフ．ホフマン－ラ ロシュ アーゲー ピラゾール誘導体、その組成物及び治療的使用
SG11201809470RA (en) * 2016-06-01 2018-11-29 Bayer Animal Health Gmbh Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
AU2017324281A1 (en) 2016-09-06 2019-03-21 F. Hoffmann-La Roche Ag 8-(azetidin-1-yl)-[1,2,4]triazolo[1,5-A]pyridinyl compounds, compositions and methods of use thereof
WO2018122212A1 (en) 2016-12-29 2018-07-05 F. Hoffmann-La Roche Ag Pyrazolopyrimidine compounds and methods of use thereof
EA037748B1 (ru) * 2017-03-09 2021-05-18 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Конденсированные имидазо-пиперидиновые ингибиторы jak
WO2018166993A2 (en) 2017-03-14 2018-09-20 F. Hoffmann-La Roche Ag Pyrazolochlorophenyl compounds, compositions and methods of use thereof
CN110603255B (zh) * 2017-05-01 2023-02-10 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的结晶型式
AR111495A1 (es) * 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
CN110573157B (zh) * 2017-05-01 2023-04-04 施万生物制药研发Ip有限责任公司 使用jak抑制剂化合物的治疗方法
BR112019024322A2 (pt) 2017-05-22 2020-06-16 F. Hoffmann-La Roche Ag Compostos e composições terapêuticos e métodos de uso dos mesmos
WO2018215390A1 (en) 2017-05-22 2018-11-29 F. Hoffmann-La Roche Ag Therapeutic compounds and compositions, and methods of use thereof
CN111587250A (zh) 2018-01-15 2020-08-25 豪夫迈·罗氏有限公司 作为jak抑制剂的吡唑并嘧啶化合物
JP7324836B2 (ja) * 2018-09-04 2023-08-10 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤としてのジメチルアミノアゼチジンアミド
MX2021002273A (es) 2018-09-04 2021-05-27 Theravance Biopharma R&D Ip Llc Proceso para preparar inhibidores de las jak y productos intermedios de estos.
KR20210056380A (ko) 2018-09-04 2021-05-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 5원 내지 7원 헤테로사이클릭 아마이드
KR20210084512A (ko) 2018-10-29 2021-07-07 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 2-아자비시클로 헥산 화합물
CN114075199A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
CN111606908B (zh) * 2019-02-25 2021-08-24 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
MA56518A (fr) 2019-06-18 2022-04-27 Hoffmann La Roche Inhibiteurs de sulfone pyrazolopyrimidine de jak kinases et leurs utilisations
JP2022537354A (ja) 2019-06-18 2022-08-25 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｊａｋキナーゼのピラゾロピリミジンアリールエーテル阻害剤及びその使用
CN114026096A (zh) 2019-06-18 2022-02-08 豪夫迈·罗氏有限公司 四唑取代的吡唑并嘧啶类jak激酶抑制剂及其用途
BR112022003564A2 (pt) 2019-08-30 2022-05-17 Rigel Pharmaceuticals Inc Composto, composição, composição seca por pulverização, método de preparação de uma composição seca por pulverização e método
JP2023508772A (ja) * 2019-12-30 2023-03-03 路良 Ｊａｋ阻害剤化合物及びその使用
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
CN115244047A (zh) * 2020-03-18 2022-10-25 四川海思科制药有限公司 一种吲唑衍生物及其在医药上的应用
CN117813298A (zh) * 2021-06-25 2024-04-02 施万生物制药研发Ip有限责任公司 作为jak抑制剂的咪唑吲唑化合物
CN117343063A (zh) * 2022-07-04 2024-01-05 河南迈英诺医药科技有限公司 作为trk抑制剂和/或ret抑制剂的化合物及其用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO2000063208A1 (en) 1999-04-16 2000-10-26 Novo Nordisk A/S Substituted imidazoles, their preparation and use
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
PL1636217T3 (pl) 2003-05-13 2009-02-27 Hoffmann La Roche 1-Imidazobenzotiazole jako ligandy receptora adenozynowego
US7884109B2 (en) * 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
ES2337831T3 (es) 2005-06-24 2010-04-29 Bristol-Myers Squibb Company Derivados de fenilglicinamida y piridilclicinamida utiles como agentes anticoagulantes.
US8648069B2 (en) * 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
ES2630026T3 (es) * 2008-12-18 2017-08-17 Nerviano Medical Sciences S.R.L. Derivados indazólicos sustituidos activos como inhibidores de cinasa
US8642324B2 (en) 2009-02-05 2014-02-04 Low Impact Limited Continuous flow worm farm
KR101127161B1 (ko) * 2009-07-13 2012-03-20 한국화학연구원 테트라히드로이미다조피리딘기가 치환된 퀴놀리논 화합물
CA2770116C (en) * 2009-08-10 2018-03-13 Epitherix, Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
US20110034441A1 (en) * 2009-08-10 2011-02-10 Epitherix, Llc Indazoles as wnt/b-catenin signaling pathway inhibitors and therapeutic uses thereof
US9249145B2 (en) * 2009-09-01 2016-02-02 Incyte Holdings Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles

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