CN115244047A - 一种吲唑衍生物及其在医药上的应用 - Google Patents

一种吲唑衍生物及其在医药上的应用 Download PDF

Info

Publication number
CN115244047A
CN115244047A CN202180012091.9A CN202180012091A CN115244047A CN 115244047 A CN115244047 A CN 115244047A CN 202180012091 A CN202180012091 A CN 202180012091A CN 115244047 A CN115244047 A CN 115244047A
Authority
CN
China
Prior art keywords
compound
fluoro
alkyl
ethyl
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180012091.9A
Other languages
English (en)
Inventor
张晨
廖雨亭
叶飞
唐平明
卢泳华
高秋
李瑶
严庞科
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Haisco Pharmaceutical Co Ltd
Original Assignee
Sichuan Haisco Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Haisco Pharmaceutical Co Ltd filed Critical Sichuan Haisco Pharmaceutical Co Ltd
Publication of CN115244047A publication Critical patent/CN115244047A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

本发明涉及一种通式(I)所述的化合物或者其立体异构体、氘代物、溶剂化物、前药、代谢产物、药学上可接受的盐或共晶，及其中间体和制备方法，以及在制备治疗JAK介导疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (16)

  1. PCT国内申请，权利要求书已公开。
CN202180012091.9A 2020-03-18 2021-03-18 一种吲唑衍生物及其在医药上的应用 Pending CN115244047A (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
CN2020101817142 2020-03-18
CN202010181714 2020-03-18
CN2020102615951 2020-04-07
CN202010261595 2020-04-07
CN2020103648168 2020-04-30
CN202010364816 2020-04-30
CN202010381106 2020-05-08
CN2020103811066 2020-05-08
CN2020105024987 2020-06-05
CN202010502498 2020-06-05
CN202010609776 2020-06-30
CN2020106097769 2020-06-30
PCT/CN2021/081467 WO2021185305A1 (zh) 2020-03-18 2021-03-18 一种吲唑衍生物及其在医药上的应用

Publications (1)

Publication Number Publication Date
CN115244047A true CN115244047A (zh) 2022-10-25

Family

ID=77770503

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180012091.9A Pending CN115244047A (zh) 2020-03-18 2021-03-18 一种吲唑衍生物及其在医药上的应用

Country Status (3)

Country Link
CN (1) CN115244047A (zh)
TW (1) TW202144346A (zh)
WO (1) WO2021185305A1 (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103717599A (zh) * 2011-07-27 2014-04-09 辉瑞有限公司 吲唑
CN110573508A (zh) * 2017-05-01 2019-12-13 施万生物制药研发Ip有限责任公司 稠合咪唑并-哌啶jak抑制剂化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103717599A (zh) * 2011-07-27 2014-04-09 辉瑞有限公司 吲唑
CN110573508A (zh) * 2017-05-01 2019-12-13 施万生物制药研发Ip有限责任公司 稠合咪唑并-哌啶jak抑制剂化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PETER JONES等: "Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin" *

Also Published As

Publication number Publication date
WO2021185305A1 (zh) 2021-09-23
TW202144346A (zh) 2021-12-01

Similar Documents

Publication Publication Date Title
JP5820921B2 (ja) １，２−二置換複素環式化合物
JP4570566B2 (ja) ピロロピリミジノン誘導体
KR100932328B1 (ko) 퀴나졸린 유도체 및 혈소판 증가증 치료에 이를 사용하는방법
BR112014004971B1 (pt) compostos heterociclilaminas, sua composição farmacêutica e seus usos
BR112018003417B1 (pt) Composto modulador alostérico positivo do receptor muscarínico de acetilcolina m4 e composição farmacêutica que o compreende
RU2650111C2 (ru) Конденсированные пирролдикарбоксамиды и их применение в качестве фармацевтических средств
EP2558463A1 (en) Fused derivatives as i3 inhibitors
CN112279848A (zh) 一种泛JAKs抑制剂及其用途
CN107382870A (zh) N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN116323625A (zh) 杂环类衍生物、其制备方法及其医药上的用途
KR101794321B1 (ko) 바이사이클릭 그룹 치환된 피리미딘 화합물
KR20230039701A (ko) 무스카린성 아세틸콜린 수용체 m4의 양성 알로스테릭 조절제로서의 7-(피페리딘-1-일)-4h-피리미도[1,2-b]피리다진-4-온 유도체
CN107849008B (zh) 一种八氢环戊烷并[c]吡咯衍生物及其制备方法和在医药上的用途
WO2017012489A1 (zh) 具有β2受体激动及M3受体拮抗活性的苯并环衍生物及其在医药上的用途
US20230348503A1 (en) Isochroman compound
JP2023113753A (ja) ヤーヌスキナーゼ（ｊａｋ）ファミリー阻害剤及びその調製と使用
CN115244047A (zh) 一种吲唑衍生物及其在医药上的应用
CN114349748A (zh) 一种吲唑衍生物、其制备方法及其在医药上的应用
WO2023143384A1 (zh) 一种抑制或降解hpk1激酶的化合物及其在医药中的用途
WO2022135390A1 (zh) 己酮糖激酶抑制剂及其用途
CN116354932A (zh) 嘧啶衍生物及其制备方法和用途
CN107849035B (zh) 一种苯基杂环衍生物及其在医药上的用途
CN113831326A (zh) 一种稠合杂环衍生物及其在医药上的应用
WO2023064584A1 (en) 7,8-dihydro-5h-1,6-naphthyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 for treating neurological and psychiatric disorders
CN117384187A (zh) 泛素特异性蛋白酶1抑制剂

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination