MXPA05010874A - Compuestos n-heterociclicos condensados y su uso como antagonistas del receptor del factor liberador de corticotropina. - Google Patents

Compuestos n-heterociclicos condensados y su uso como antagonistas del receptor del factor liberador de corticotropina.

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Publication number
MXPA05010874A
MXPA05010874A MXPA05010874A MXPA05010874A MXPA05010874A MX PA05010874 A MXPA05010874 A MX PA05010874A MX PA05010874 A MXPA05010874 A MX PA05010874A MX PA05010874 A MXPA05010874 A MX PA05010874A MX PA05010874 A MXPA05010874 A MX PA05010874A
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MX
Mexico
Prior art keywords
substituted
halo
alkoxy
alkyl
nitrogen
Prior art date
Application number
MXPA05010874A
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English (en)
Inventor
Yves St-Denis
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Sb Pharmco Inc
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Publication date
Application filed by Sb Pharmco Inc filed Critical Sb Pharmco Inc
Publication of MXPA05010874A publication Critical patent/MXPA05010874A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

La presente invencion provee compuestos de formula (I) incluyendo estereoisomeros, profarmacos y sales farmaceuticamente aceptables o solvatos de las mismas (Formula (I)) (ver formula (I)) en donde la linea punteada puede representar un enlace doble; R es arilo o heteroarilo, cada uno de los cuales se puede sustituir por 1 a 4 grupos J seleccionados a partir del: halogeno, alquilo de C1-C6, alcoxi de C1-C6, haloalquilo de C1-C6, alquenilo de C2-C6, alquinilo de C2-C6, haloalcoxi de C1-C6, -C(O)R2, nitro, hidroxi, -NR3R4, ciano y o un grupo Z; R1 es hidrogeno, cicloalquilo de C3-C7, alquilo de C1-C6, alcoxi de C1-C6, tioalquilo de C1-C6, alquenilo de C2-C6, alquinilo de C2-C6, haloalquilo de C1-C6, halo C1-C6 alkoxi, halogeno, NR3R4 o ciano; D, G es -C- opcionalmente sustituido; X es carbono o nitrogeno; Y es nitrogeno o -C- opcionalmente sustituido; W es un anillo de 4-8 miembros, el cual puede estar saturado o puede contener de uno a tres enlaces dobles, y en el cual: -un atomo de carbono se reemplaza por un carbonilo o S(O)m; y -de uno a cuatro atomos de carbono se pueden reemplazar por oxigeno, nitrogeno o NR12, S(O)m, carbonilo, y dicho anillo puede estar adicionalmente sustituido por 1 a 8 sustituyentes; Z es un heterociclo de 5-6 miembros, el cual se puede sustituir por 1 a 8 grupos R5 o un anillo fenilo, el cual se puede sustituir por 1 a 4 sustituyentes; m es un entero de 0 a 2; a procedimientos para su operacion, a composiciones farmaceuticas que los contienen y a su uso en el tratamiento de condiciones mediadas por el factor liberador de corticotropina (CRF).
MXPA05010874A 2003-04-09 2004-04-07 Compuestos n-heterociclicos condensados y su uso como antagonistas del receptor del factor liberador de corticotropina. MXPA05010874A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0308208.8A GB0308208D0 (en) 2003-04-09 2003-04-09 Chemical compounds
US48532203P 2003-07-07 2003-07-07
PCT/IB2004/001350 WO2004094420A1 (en) 2003-04-09 2004-04-07 Condensed n-heterocyclic compounds and their use as crf receptor antagonists

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MXPA05010874A true MXPA05010874A (es) 2006-03-21

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MXPA05010874A MXPA05010874A (es) 2003-04-09 2004-04-07 Compuestos n-heterociclicos condensados y su uso como antagonistas del receptor del factor liberador de corticotropina.

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US (2) US7427630B2 (es)
EP (3) EP2186813A1 (es)
JP (2) JP4866722B2 (es)
KR (1) KR20060021826A (es)
CN (1) CN1805958A (es)
AR (1) AR044005A1 (es)
AT (2) ATE473226T1 (es)
AU (1) AU2004232551C1 (es)
BR (1) BRPI0409117A (es)
CA (1) CA2521929C (es)
DE (2) DE602004027998D1 (es)
GB (1) GB0308208D0 (es)
IS (1) IS8119A (es)
MA (1) MA27796A1 (es)
MX (1) MXPA05010874A (es)
NO (1) NO20055238L (es)
NZ (1) NZ542780A (es)
PL (1) PL378755A1 (es)
RU (1) RU2382785C2 (es)
TW (1) TW200508232A (es)
WO (2) WO2004094420A1 (es)

Families Citing this family (50)

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Publication number Priority date Publication date Assignee Title
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
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